Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kenichiro Handa"'
Autor:
Kenichiro Handa, Yuko Yamakawa, I-Shan Chen, Kazuharu Furutani, Yoshihisa Kurachi, Jon T. Sack, Kunichika Tsumoto
Publikováno v:
The Journal of General Physiology
Some hERG channel blockers are clinically safe, but others cause fatal cardiac arrhythmias. Furutani et al. show that safe blockers facilitate channel opening in ventricular myocytes and provide a repolarization reserve at precisely the voltages and
Autor:
Kunichika Tsumoto, Kenichiro Handa, Yuko Yamakawa, Jon T. Sack, Kazuharu Furutani, I-Shan Chen, Yoshihisa Kurachi
Fatal cardiac arrhythmias are caused by some, but not all, drugs that inhibit the cardiac rapid delayed-rectifier current (IKr) by blocking hERG channels. Here, we propose a novel mechanism that could make certain hERG blockers less proarrhythmic. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208fe65117a8c3a154c7904ae6d9386b
https://doi.org/10.1101/341875
https://doi.org/10.1101/341875
Autor:
Kazuharu Furutani1,2,3, Kunichika Tsumoto1,4 kfurutani@ucdavis.edu, I-Shan Chen1, Kenichiro Handa1, Yuko Yamakawa1, Sack, Jon T.3, Yoshihisa Kurachi1,2 ykurachi@pharma2.med.osaka-u.ac.jp
Publikováno v:
Journal of General Physiology. Feb2019, Vol. 151 Issue 2, p214-230. 17p.