Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Kenichi Nunami"'
2
Studies on Angiotensin Converting Enzyme Inhibitors. V. The Diastereoselective Synthesis of 2-Oxoimidazolidine Derivatives
Autor: Masafumi Yamagishi, Kenichi Nunami, Kimiaki Hayashi, Sigeru Nisimoto, Hitoshi Kubota
Publikováno v: Chemical and Pharmaceutical Bulletin. 39:1374-1377
A diastereoselective syntesis of imidapril (1), which is under clinical study as an antihypertensive drug based on its angiotensin converting enzyme (ACE)-inhibitory activity, was established. N-Alkylation of (2S)-2-amino-4-phenylbutyric acid ester (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9752cef51f42e1d209c722aae5ae8125
https://doi.org/10.1248/cpb.39.1374
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3
A Facile Synthesis of Methyl 1,5-Disubstituted Imidazole-4-carboxylates
Autor: Kenichi Nunami, Kiwamu Hiramatsu, Kazuo Matsumoto, Kimiaki Hayashi
Publikováno v: Synthesis. 1990:781-782
Varioustitle compounds are synthesized by the reaction of methyl 3-bromo-2-isocyanoacrylates with a variety of primary amines in the presence of triethylamine.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a551526636f741e5bc75bbec3b6ff2eb
https://doi.org/10.1055/s-1990-27013
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4
Synthesis of βγ-unsaturated α-amino-acids
Autor: Kenichi Nunami, Mamoru Suzuki, Naoto Yoneda
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :2224-2229
Saponification of methyl N-formylcycloalkylideneglycinates (3) gave N-formylcycloalk-1 -enylglycines (4) through migration of the double bond. The compounds (4) were converted into cycloalk-1-enylglycines (6) by acid hydrolysis. On the results of mec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d600e5f18b987e29047a8b8dc9b872d
https://doi.org/10.1039/p19790002224
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5
Syntheses of 3-substituted pyrrole derivatives with antiinflammatory activity
Autor: Yoshio Iwasawa, Naoto Yoneda, Yuichi Onoda, Kenichi Nunami, Kazuo Sakai, Mamoru Suzuki
Publikováno v: Chemical and Pharmaceutical Bulletin. 28:2384-2393
Various dimethyl 3-substituted pyrrole-2, 4-dicarboxylates (3) were synthesized by the reaction of methyl isocyanoacetate (2) with methyl α-isocyanoacrylates (5) in the presence of base. This type of reaction was also applicable to the preparation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7ad82f3a7aef813b5b632c9292ddd5
https://doi.org/10.1248/cpb.28.2384
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6
Synthesis and herbicidal activities of .ALPHA.-isocyanocycloalkylideneacetamides
Autor: Kazuo Matsumoto, Mamoru Suzuki, Naoto Yoneda, Kazuo Takiguchi, Kenichi Nunami, Kimiaki Hayashi
Publikováno v: Agricultural and Biological Chemistry. 49:3023-3028
Various α-isocyanocycloalkylideneacetamides were synthesized by the reaction of isocyanoacetamides with ketones and following by dehydration. These compounds were examined for their inhibitory activity against the germination of rice, cucumber and r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5958bf4ba119453a06cb6d9000b7fd05
https://doi.org/10.1271/bbb1961.49.3023
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7
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives
Autor: Naoto Yoneda, Masami Kubo, Jyoji Kato, Takashi Ochiai, Kenichi Nunami, Kimiaki Hayashi, Ryuichi Ishida
Publikováno v: Journal of Medicinal Chemistry. 32:289-297
(4S)-1-Alkyl-3-[[N-(carboxyalkyl)amino]acyl]-2-oxoimidazolidine-4- carboxylic acid derivatives (3) were prepared by two methods. Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the stru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2684b616ac8d06a291d5bd41b4f2da32
https://doi.org/10.1021/jm00122a003
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9
Studies on angiotensin-converting enzyme inhibitors. I. Syntheses and angiotensinconverting enzyme inhibitory activity of 2-(3-mercaptopropionyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives
Autor: Naoto Yoneda, Kimiaki Hayashi, Tomofumi Uchida, Keizo Kinashi, Y. Ozaki, Kenichi Nunami, Jyoji Kato
Publikováno v: Chemical and Pharmaceutical Bulletin. 31:570-576
(3S)-2-[(2S)-3-Mercapto-2-methylpropionyl]-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid [(3S), (2S)-6a] was prepared by the reaction of (3S)-1, 2, 3, 4-tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester [(3S)-2a] or benzyl ester [(3S)-2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d63e8d0aa198d234f95a6d27cadd597
https://doi.org/10.1248/cpb.31.570
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10
Synthesis of amino acids and related compounds. Part 37. Antifungal activities of .ALPHA.-isocyanoacetanilides
Autor: Mamoru Suzuki, Kenichi Nunami, Kazuo Matsumoto, Kazuo Takiguchi, Kunihiko Yamada, Kimiaki Hayashi
Publikováno v: Agricultural and Biological Chemistry. 53:69-76
A series of α-isocyanoacetic acid compounds was examined for their inhibitory activities against several plant-fungi. Among them, various α-isocyanoacetamides showed protective effects against Sphaerotheca fuliginea, Cladosporium fulvum and Phytoph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67dce41697d27ede2d3e46bcb9bb236c
https://doi.org/10.1271/bbb1961.53.69
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