Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kenichi Miyoshi"'
Autor:
Kinya Okamoto, Masahiko Koda, Toshiaki Okamoto, Takumi Onoyama, Kenichi Miyoshi, Manabu Kishina, Tomomitsu Matono, Jun Kato, Shiho Tokunaga, Takaaki Sugihara, Akira Hiramatsu, Hideyuki Hyogo, Hiroshi Tobita, Shuichi Sato, Miwa Kawanaka, Yuichi Hara, Keisuke Hino, Kazuaki Chayama, Yoshikazu Murawaki, Hajime Isomoto
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0219412 (2020)
INTRODUCTION:Non-alcoholic fatty liver disease (NAFLD) has a wide spectrum, eventually leading to cirrhosis and hepatic carcinogenesis. We previously reported that a series of microRNAs (miRNAs) mapped in the 14q32.2 maternally imprinted gene region
Externí odkaz:
https://doaj.org/article/cc897b9b031c4932879792bf6f0c1385
Autor:
Kinya Okamoto, Masahiko Koda, Toshiaki Okamoto, Takumi Onoyama, Kenichi Miyoshi, Manabu Kishina, Jun Kato, Shiho Tokunaga, Taka-Aki Sugihara, Yuichi Hara, Keisuke Hino, Yoshikazu Murawaki
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154676 (2016)
BACKGROUND & AIMS:Simple steatosis (SS) and non-alcoholic steatohepatitis (NASH) are subtypes of non-alcoholic fatty liver disease (NAFLD), and the pathogenic differences between SS and NASH remain unclear. MicroRNAs (miRNAs) are endogenous, non-codi
Externí odkaz:
https://doaj.org/article/751f66a75b024d628e0aa025cbdcbb41
Autor:
Takashi Moritoyo, Tomoko Hasunuma, Kazuhiro Harada, Tomonori Tateishi, Makoto Watanabe, Tsutomu Kotegawa, Masahiro Nagai, Yuji Kumagai, Tomomichi Fujitani, Takahumi Okura, Tomikazu Fukuoka, Kenichi Miyoshi, Bunzo Matsuura, Shinya Furukawa, Tomoe Kobori, Hiroyoko Moritoyo, Noriko Nishikawa, Tomoaki Tsujii, Hirotaka Iwaki, Masahiko Nakamura, Satoshi Makino, Kei Ohnuma, Koichiro Yuji, Megumi Hashimoto, Masaru Takasu, Yutaka Hashizume, Koji You, Tomoko Matsumura, Yuji Tanaka, Nahoko Matsumoto, Junichi Nakamura, Jun Miura, Tadao Akizawa, Kozo Kitazawa, Takanori Shibata, Aki Kuroki, Hirokazu Honda, Masanori Mukai, Kyoichi Ohashi, Takuya Morimoto, Hiromitsu Imai, Toshiaki Okudaira, Fuminori Sato, Junko Imanaga, Katsuhiro Tanaka, Masahiro Nomoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 4, Pp 324-329 (2012)
The effect of renal impairment on the pharmacokinetics of a single oral dose of memantine (10 mg) was determined in Japanese subjects. Subjects were assigned to four groups based on baseline creatinine clearance (CLCR): normal renal function (> 80 mL
Externí odkaz:
https://doaj.org/article/30a4c5ce385f43e8a9e2bb919dd32a73
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77623 (2013)
BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is highly resistant to chemotherapy, including gemcitabine (Gem) treatment. MicroRNAs (miRNAs) are endogenous, non-coding, short RNAs that can regulate multiple genes expression. Some miRNAs play importan
Externí odkaz:
https://doaj.org/article/042b51c970554e66b806a9a94b8aadc9
Autor:
Tsuyoshi Kawai, Shinsaku Yata, Kensuke Matsumoto, Kenichi Miyoshi, Naoya Noguchi, Shinya Fujii
Publikováno v:
Interventional Radiology. 7:114-118
Autor:
Takakazu Nagahara, Yukako Matsuki, Jun-ichi Okano, Yoshiki Hoshino, Kenji Ohyama, Suguru Ikeda, Masahiko Sugitani, Kenichi Miyoshi, Hajime Isomoto, Takaaki Sugihara, Tomomitu Matono
Publikováno v:
Kanzo. 62:420-428
Autor:
Yuki, Imaizumi, Kazunori, Takanuki, Takuya, Miyake, Mizuki, Takemoto, Kunio, Hirata, Mika, Hirose, Rika, Oi, Tatsuya, Kobayashi, Kenichi, Miyoshi, Rie, Aruga, Tatsuhiko, Yokoyama, Shizuka, Katagiri, Hiroaki, Matsuura, Kenji, Iwasaki, Takayuki, Kato, Mika K, Kaneko, Yukinari, Kato, Michiko, Tajiri, Satoko, Akashi, Osamu, Nureki, Yohei, Hizukuri, Yoshinori, Akiyama, Terukazu, Nogi
Publikováno v:
Science advances. 8(34)
Site-2 proteases are a conserved family of intramembrane proteases that cleave transmembrane substrates to regulate signal transduction and maintain proteostasis. Here, we elucidated crystal structures of inhibitor-bound forms of bacterial site-2 pro
Autor:
Yuki Imaizumi, Kazunori Takanuki, Takuya Miyake, Mizuki Takemoto, Kunio Hirata, Mika Hirose, Rika Oi, Tatsuya Kobayashi, Kenichi Miyoshi, Rie Aruga, Tatsuhiko Yokoyama, Shizuka Katagiri, Hiroaki Matsuura, Kenji Iwasaki, Takayuki Kato, Mika K. Kaneko, Yukinari Kato, Michiko Tajiri, Satoko Akashi, Osamu Nureki, Yohei Hizukuri, Yoshinori Akiyama, Terukazu Nogi
Site-2 proteases are a conserved family of intramembrane proteases that cleave transmembrane substrates to regulate signal transduction and maintain proteostasis. Here, we elucidated crystal structures of inhibitor-bound forms of bacterial site-2 pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82d7ab48ef97e61161c9ce96fa1260f
https://doi.org/10.1101/2022.01.31.478169
https://doi.org/10.1101/2022.01.31.478169
Autor:
Takakazu Nagahara, Masafumi Yamane, Jun-ichi Okano, Kenichi Miyoshi, Yukako Matsuki, Masahiko Koda, Ran Nagahara, Hajime Isomoto, Takaaki Sugihara, Tomomitsu Matono, Toshiaki Okamoto
Publikováno v:
Yonago Acta Medica. 2019, 62(1), 30-35
[Background] The options for the treatment of nonalcoholic steatohepatitis (NASH) are limited. We examined the effects of ipragliflozin, a sodium-glucose cotransporter 2 inhibitor, on the fatty liver Shionogi (FLS)-ob/ob mice, a non-alcoholic steatoh
Autor:
Kenichi Miyoshi, Takakazu Nagahara, Jun-ichi Okano, Ran Nagahara, Hajime Isomoto, Masafumi Yamane, Masahiko Koda, Yukako Matsuki, Takaaki Sugihara, Tomomitsu Matono, Toshiaki Okamoto
Publikováno v:
Yonago Acta Medica. 2019, 62(1), 36-46
[Background] Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is a chronic liver disease related to metabolic syndrome that can progress to liver cirrhosis. The involvement of the endoplasmic reticulum (ER) stress response in NAFLD progr