Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kenichi Kishida"'
Autor:
Mariko Yamano, Tetsuo Sasabe, Yoshihiro Miwa, Kenichi Kishida, Toshihiro Sugiyama, Shinichiro Maeda
Publikováno v:
Drug Metabolism Letters
Objective Drug therapy is occasionally accompanied by an idiosyncratic severe toxicity, which occurs very rarely, but can lead to patient mortality. Methazolamide, an anti-glaucomatous agent, could cause severe skin eruptions called Stevens-Johnson s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d5c7a2ccdefd2aa6f02a623daa0f29
https://pubmed.ncbi.nlm.nih.gov/28137210
https://pubmed.ncbi.nlm.nih.gov/28137210
Autor:
Yasutaka Shibata, Hideto Shimahara, Yasuo Tano, Tadayasu Ohkubo, Shinya Ohki, Takuya Yoshida, Hozumi Moriyama, Masato Shimizu, Takeshi Kato, Shin-ichi Tate, Kenichi Kishida, Yuji Kobayashi, Fumio Sakiyama, Takashi Nakazawa, Yoshimasa Kyogoku
Publikováno v:
Journal of Biological Chemistry. 282:9646-9656
The imidazole (15)N signals of histidine 64 (His(64)), involved in the catalytic function of human carbonic anhydrase II (hCAII), were assigned unambiguously. This was accomplished by incorporating the labeled histidine as probes for solution NMR ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2df17c8f3538efdf23c83f81163cfd
https://doi.org/10.1074/jbc.m609679200
https://doi.org/10.1074/jbc.m609679200
Publikováno v:
Journal of Pharmaceutical Sciences. 90:224-233
Bovine kidney and liver homogenates degraded a cysteine conjugate of methazolamide, S-(5-acetylimino-4-methyl-Delta2-1,3,4-thiadiazolin-2-yl)cysteine. We isolated the degradation product following incubation with kidney homogenate by high-performance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7577ec53912581a95e523230f036e21e
https://doi.org/10.1002/1520-6017(200102)90:2<224::aid-jps13>3.0.co
https://doi.org/10.1002/1520-6017(200102)90:2<224::aid-jps13>3.0.co
Publikováno v:
Microbiology and Immunology. 41:27-32
Through the adoption of a chiral stationary phase in high-performance liquid chromatography and a simple derivatization method for hydroxy fatty acids, it became easy to separate and identify the optical isomers of 2- and 3-hydroxy fatty acids compos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff0d79918ecef71b9940cb0f523fa34
https://doi.org/10.1111/j.1348-0421.1997.tb01169.x
https://doi.org/10.1111/j.1348-0421.1997.tb01169.x
Publikováno v:
Ophthalmic Research. 28:201-208
Among the Arg-Gly-Asp (RGD)-containing sequences that are known to be cell-binding domains of fibronectin, 500 migrograms/ml of Arg-Gly-Asp-Ser (RGDS) and Gly-Arg-Gly-Asp-Ser showed 100% inhibition of the attachment of cultured lens epithelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2388181304dcae8b31514fca08986bbe
https://doi.org/10.1159/000267904
https://doi.org/10.1159/000267904
Publikováno v:
Ophthalmic Research. 26:41-50
The excised rat crystalline lens opacified when incubated aerobically with phenazine methosulfate, but no opacification was observed under anaerobic conditions. Morphological studies revealed development of opacification in the cortex. The opacificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6566f255300ebe1b23b50cdd26e4c5
https://doi.org/10.1159/000267373
https://doi.org/10.1159/000267373
Autor:
Yoshiaki Iwai, Tetsuo Sasabe, Kenichi Kishida, Norihiro Yamamura, Yoshiteru Sakamoto, Makihiko Kuhara
Publikováno v:
Drug metabolism letters. 5(1)
The in vivo metabolism of methazolamide, a carbonic anhydrase inhibitor, was studied using guinea pigs as the animals. (14)C-Labeled methazolamide was synthesized. Eighty percent of intraperitoneally injected radioactivity was recovered from urine an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acbe4b19a7ed1dfffe8cd9dae8f9034
https://pubmed.ncbi.nlm.nih.gov/21198437
https://pubmed.ncbi.nlm.nih.gov/21198437
Publikováno v:
Journal of Pharmaceutical Sciences. 79:638-642
Conjugation reaction of methazolamide with glutathione and its subsequent reactions were studied in vitro. Glutathione, cysteinylglycine, and cysteine conjugates of methazolamide were chemically synthesized. All of the three compounds showed absorban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8407e688bfef4a2e8a52f6731a52373b
https://doi.org/10.1002/jps.2600790720
https://doi.org/10.1002/jps.2600790720
Publikováno v:
Current Eye Research. 3:779-782
Studies were made on neutrophil dysfunction in Behçet disease by examining collagenolytic activity in neutrophils. The collagenolytic activity of neutrophil was found to be significantly higher in patients during the attack phase of this disease tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da178ceb2944ca0af9ce25b2f7527c2c
https://doi.org/10.3109/02713688409000789
https://doi.org/10.3109/02713688409000789
Publikováno v:
Current Eye Research. 5:529-533
Microsomes were prepared from bovine ciliary bodies. The contents of cytochrome P-450 and related components of the microsomal electron transport system were determined. The cytochrome P-450 content was 32 pmoles/mg protein, which was about 4% that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fa127587019251b22de6701497ec04
https://doi.org/10.3109/02713688608996376
https://doi.org/10.3109/02713688608996376