Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kenichi Imahashi"'
Autor:
Misato Nakanishi-Koakutsu, Kenji Miki, Yuki Naka, Masako Sasaki, Takayuki Wakimizu, Stephanie C. Napier, Chikako Okubo, Megumi Narita, Misato Nishikawa, Reo Hata, Kazuhisa Chonabayashi, Akitsu Hotta, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Current differentiation protocols for human induced pluripotent stem cells (hiPSCs) produce heterogeneous cardiomyocytes (CMs). Although chamber-specific CM selection using cell surface antigens enhances biomedical applications, a cell surfa
Externí odkaz:
https://doaj.org/article/73e8538871d040e3ae7023f2f88a2a49
Autor:
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation
Externí odkaz:
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
Autor:
Taku Monjo, Tomoyuki Nishimoto, Yuya Fujiwara, Norihisa Tamura, Masako Sasaki, Yoshinori Yoshida, Takeshi Hatani, Chikako Okubo, Shigeru Kondo, Tatsuya Ando, Kenji Miki, Misato Nakanishi-Koakutsu, Tsukasa Sugo, Kenichi Imahashi, Ikue Takei, Yuki Naka, Antonio Lucena-Cacace, Sachiko Imaichi, Megumi Narita, Stephanie C. Napier, Kohei Deguchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we generate human induced pluripotent stem cells (hiPSCs) carrying a TNNI1[EmGFP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1caae6fb715db7abebf5f35ec46fe5
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
https://doaj.org/article/e591e23480c3403b95a1cc6ecca9b455
Autor:
Mariko Yoneyama-Hirozane, Shiro Takekawa, Junichi Sakamoto, Kenichi Imahashi, Tsuyoshi Ishii, Junji Matsui, Yoshihide Nakano, Takeshi Hirakawa, Kohei Deguchi, Tomoyuki Odani, Ikumi Chisaki, Nobuyuki Takakura
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(2)
Ghrelin O-acyl transferase (GOAT; MBOAT4) catalyzes O-acylation at serine-3 of des-acyl ghrelin. Acyl ghrelin is secreted by stomach X/A-like cells and plays a role in appetite and metabolism. Therefore, GOAT has been expected to be a novel antiobesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4881be1b8d192e44fa7e4e2ebdc29007
https://pubmed.ncbi.nlm.nih.gov/28846466
https://pubmed.ncbi.nlm.nih.gov/28846466
Autor:
Toshikatsu Matsui, Kenichi Imahashi, Masamitsu Gotou, Kozo Hayashi, Tomoyuki Nishimoto, Hiroyuki Kobayashi
Publikováno v:
Biochemical and biophysical research communications. 488(2)
β1-adrenergic receptor (Adrb1) belongs to the superfamily of G-protein-coupled receptors (GPCRs) and plays a critical role in the regulation of heart rate and myocardial contraction force. GPCRs are phosphorylated at multiple sites to regulate disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca013356536c6d43a20cc1b7764bb67
https://pubmed.ncbi.nlm.nih.gov/28501616
https://pubmed.ncbi.nlm.nih.gov/28501616
Publikováno v:
SLAS Discovery. 17:1192-1203
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) at different stages (approximate days 30, 60, and 90) were used to determine the appropriate stage for functional and morphological assessment of drug effects in vitro. The hiPS-CM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c2813ce450f2fa59ac13654b70c32f
https://doi.org/10.1177/1087057112449864
https://doi.org/10.1177/1087057112449864
Autor:
Kenichi Imahashi, Hiroyoshi Toyoshiba, Ryoet S U Imai, Hiroshi Sawada, Kosuke Nakashima, Satoshi Yamamoto, Kenji Takami, Akiko Tsuji, Tadahiro Shinozawa
Publikováno v:
SLAS Discovery. 14:239-245
Although embryonic stem cell (ESC)-derived cardiomyocytes may be a powerful tool in drug discovery, their potential has not yet been fully explored. Nor has a detailed comparison with adult heart tissue been performed. We have developed a method for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7024bf9518251a8590c37cb666732b0
https://doi.org/10.1177/1087057108330112
https://doi.org/10.1177/1087057108330112
Autor:
Atilla Kovacs, Catherine R. Dufour, Janice M. Huss, Vincent Giguère, Elizabeth Murphy, Kenichi Imahashi, Daniel P. Kelly, Carla J. Weinheimer, Michael Courtois
Publikováno v:
Cell Metabolism. 6:25-37
Downregulation and functional deactivation of the transcriptional coactivator PGC-1alpha has been implicated in heart failure pathogenesis. We hypothesized that the estrogen-related receptor alpha (ERRalpha), which recruits PGC-1alpha to metabolic ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd74b9ef374137808c7e1315f6d085a
https://doi.org/10.1016/j.cmet.2007.06.005
https://doi.org/10.1016/j.cmet.2007.06.005
Publikováno v:
Circulation Research. 95:734-741
The antiapoptotic protein Bcl-2 is targeted to the mitochondria, but it is uncertain whether Bcl-2 affects only myocyte survival after ischemia, or whether it also affects metabolic functions of mitochondria during ischemia. Hearts from mice overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d625889a0091046429765a3efa0386a
https://doi.org/10.1161/01.res.0000143898.67182.4c
https://doi.org/10.1161/01.res.0000143898.67182.4c
Autor:
Paul G. Yock, Donna M. Bouley, Felix H. Lee, Fumiaki Ikeno, Koichi Inagaki, Leon Chen, Kenichi Imahashi, Daria Mochly-Rosen, Mehrdad Rezaee, Elizabeth Murphy
Publikováno v:
Circulation. 108:2304-2307
Background— Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that δ-protein kinase C (δPKC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ef5119b6ffbaed2fd53f7a9d970de7
https://doi.org/10.1161/01.cir.0000101682.24138.36
https://doi.org/10.1161/01.cir.0000101682.24138.36