Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kenichi Washizuka"'
Autor:
Takehiro Fukami, Yui Mazaki, Kenichi Washizuka, Hideaki Niwa, Takeshi Tsumura, Hiroo Koyama, Yuko Kano, Yasuko Koda, Fumiyuki Shirai, Kouichi Kitamura, Yoko Yashiroda, Anna Mizutani, Hitomi Yuki, Eiki Shitara, Hiroyuki Seimiya, Teruki Honma, Shin Sato, Tsubasa Chikada, Minoru Yoshida, Masayuki Okue, Takashi Watanabe, Takashi Umehara, Yukiko Muramatsu, Akiko Nagamori, Myung-Kyu Jang, Haruka Yoshida, Mikako Shirouzu
Publikováno v:
Journal of medicinal chemistry. 63(8)
Tankyrases (TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase family. Inhibition of their enzymatic activities attenuates the Wnt/β-catenin signaling, which plays an important role in cancer pathogenesis. We previously reported the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30c01958ef416b8aff1cab18d74f999
https://pubmed.ncbi.nlm.nih.gov/32202790
https://pubmed.ncbi.nlm.nih.gov/32202790
Autor:
Kenichi Washizuka, Yasuhiro Matsumura, Yasuyo Tomishima, Keiko Nakano, Naoko Unami, Fujiko Takamura, Takanobu Araki, Shigeo Matsui, Minoru Sakurai, Masashi Imanishi, Takao Yamamoto, Kaori Hamada, Kouji Hattori, Hitoshi Hamashima, Nobuhiro Yamamoto, Emiko Imamura, Hirofumi Ishikawa, Koji Ueshima, Yutaka Nakajima, Susumu Toda, Shinji Itou
Publikováno v:
Journal of Medicinal Chemistry. 52:3063-3072
As an extension of research conducted on beta(3)-adrenergic receptor agonists as potential drugs for treating overactive bladder (OAB), novel series containing an acylsulfonamide moiety instead of the carboxylic acid moiety were evaluated. These comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db696b5f389955fb00201a425aef2632
https://doi.org/10.1021/jm9000709
https://doi.org/10.1021/jm9000709
Autor:
Masashi, Imanishi, Yasuyo, Tomishima, Shinji, Itou, Hitoshi, Hamashima, Yutaka, Nakajima, Kenichi, Washizuka, Minoru, Sakurai, Shigeo, Matsui, Emiko, Imamura, Koji, Ueshima, Takao, Yamamoto, Nobuhiro, Yamamoto, Hirofumi, Ishikawa, Keiko, Nakano, Naoko, Unami, Kaori, Hamada, Yasuhiro, Matsumura, Fujiko, Takamura, Kouji, Hattori
Publikováno v:
Journal of Medicinal Chemistry. 51:1925-1944
A novel class of biphenyl analogues containing a benzoic acid moiety based on lead compound 8i have been identified as potent and selective human beta 3 adrenergic receptor (beta 3-AR) agonists with good oral bioavailability and long plasma half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3df2218288fe87564bacbf9f841e0ed
https://doi.org/10.1021/jm701324c
https://doi.org/10.1021/jm701324c
Autor:
Yasuyo Tomishima, Kenichi Washizuka, Masayuki Kato, Hitoshi Hamashima, Yutaka Nakajima, Toshiko Miura, Hiroshi Kayakiri, Emiko Imamura, Hiroaki Ohtake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:251-254
The discovery of a novel, potent and selective β3-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good β3-AR activity and selectivity, was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cba7b3143ff5d369186e60ac75f43d
https://doi.org/10.1016/j.bmcl.2004.11.001
https://doi.org/10.1016/j.bmcl.2004.11.001
Publikováno v:
Tetrahedron Letters. 40:8849-8853
Novel and facile generation of azomethine imines from α-silylnitrosamines and subsequent cycloaddition with dipolarophiles leading to a variety of pyrazole derivatives have been developed. The key to the reaction is a 1,4-silatropic shift caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94688f3d940224c018615072a8c62118
https://doi.org/10.1016/s0040-4039(99)01859-6
https://doi.org/10.1016/s0040-4039(99)01859-6
Autor:
Fumiyuki Shirai, Toshiaki Kamimura, Masayoshi Murata, Satoru Kuroda, Kenichi Washizuka, Hidenori Azami, Keiji Matsuda, Toshiyuki Chiba, Hideo Tsutsumi, Minoru Sakurai, David A. Barrett
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:1665-1682
The synthesis and biological activity of a novel series of 2-alkyl-4-pyrrolidinylthio-β-methylcarbapenems containing a variety of cationic heteroaromatic substituents is described. As a result of these studies, we uncovered a relationship between in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2c35d3bf7555f05888d2c89cd64ca0c
https://doi.org/10.1016/s0968-0896(99)00085-1
https://doi.org/10.1016/s0968-0896(99)00085-1
Publikováno v:
Bulletin of the Chemical Society of Japan. 69:2079-2090
Catalytic cross double carbonylation of secondary amines and alcohols proceeds in the presence of [PdCl2(MeCN)2] and CuI under carbon monoxide (80 atm) and oxygen (5 atm). Catalytic intramolecular double carbonylation of β-amino alcohols gives morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c35a6de05570835fce271216432cc7
https://doi.org/10.1246/bcsj.69.2079
https://doi.org/10.1246/bcsj.69.2079
Publikováno v:
ChemInform. 27
Catalytic cross double carbonylation of secondary amines and alcohols proceeds in the presence of [PdCl2(MeCN)2] and CuI under carbon monoxide (80 atm) and oxygen (5 atm). Catalytic intramolecular double carbonylation of β-amino alcohols gives morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::022e438e6af7f36bb0cc1fdc58f3c97d
https://doi.org/10.1002/chin.199642069
https://doi.org/10.1002/chin.199642069
Publikováno v:
ChemInform. 31
Novel and facile generation of azomethine imines from α-silylnitrosamines and subsequent cycloaddition with dipolarophiles leading to a variety of pyrazole derivatives have been developed. The key to the reaction is a 1,4-silatropic shift caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90196253267e1588a44233a513c2ab13
https://doi.org/10.1002/chin.200009129
https://doi.org/10.1002/chin.200009129
Autor:
Naoko Unami, Minoru Sakurai, Keiko Nakano, Shinji Itou, Kenichi Washizuka, Shigeo Matsui, Kaori Hamada, Yasuhiro Matsumura, Kouji Hattori, Koji Ueshima, Takanobu Araki, Masashi Imanishi, Daisuke Tanabe, Emiko Imamura, Hirofumi Ishikawa, Susumu Toda, Masaya Orita, Yutaka Nakajima, Takao Yamamoto, Fujiko Takamura, Nobuhiro Yamamoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
As an extension of research, we have investigated modification of left-hand side (LHS) of biphenyl analogues containing an acylsulfonamide moiety in the development of potent and selective human beta(3)-adrenergic receptor (AR) agonists. Result of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f9b3c86a36d8cbaa684b03b5353c4
https://pubmed.ncbi.nlm.nih.gov/19608416
https://pubmed.ncbi.nlm.nih.gov/19608416