Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Kenichi, Miharada"'
Autor:
Svetlana Soboleva, Ryo Kurita, Fredrik Ek, Hugo Åkerstrand, Rita Silvério-Alves, Roger Olsson, Yukio Nakamura, Kenichi Miharada
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
In an imaging-based screen of >3,300 compounds compounds, Soboleva et al identify HDAC inhibitors as mediators of erythroid cell enucleation. They further show that the erythroid-specific cell membrane protein, SPTA1, is downregulated in HDAC inhibit
Externí odkaz:
https://doaj.org/article/61f572de14eb48a18df29210fe97c443
Autor:
Shuhei Koide, Valgardur Sigurdsson, Visnja Radulovic, Kiyoka Saito, Zhiqian Zheng, Stefan Lang, Shamit Soneji, Atsushi Iwama, Kenichi Miharada
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103603- (2022)
Summary: Isolation of long-term hematopoietic stem cell (HSC) is possible by utilizing flow cytometry with multiple cell surface markers. However, those cell surface phenotypes do not represent functional HSCs after in vitro culture. Here we show tha
Externí odkaz:
https://doaj.org/article/4ed8a9b81e1147e4ae4d1b2ef49c5c25
Autor:
Anna Rydström, Els Mansell, Valgardur Sigurdsson, Julia Sjöberg, Shamit Soneji, Kenichi Miharada, Jonas Larsson
Publikováno v:
Stem Cell Reports. 18:736-748
Autor:
Karolina Komorowska, Alexander Doyle, Martin Wahlestedt, Agatheeswaran Subramaniam, Shubhranshu Debnath, Jun Chen, Shamit Soneji, Ben Van Handel, Hanna K.A. Mikkola, Kenichi Miharada, David Bryder, Jonas Larsson, Mattias Magnusson
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3514-3523 (2017)
Summary: The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and
Externí odkaz:
https://doaj.org/article/93653e5e1b494a609acf2a52b536dffe
Autor:
Visnja Radulovic, Mark van der Garde, Shuhei Koide, Valgardur Sigurdsson, Stefan Lang, Shin Kaneko, Kenichi Miharada
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2826-2836.e5 (2019)
Summary: The distinct lineage potential is a key feature of hematopoietic stem cell (HSC) heterogeneity, but a subset of HSCs specialized for a single lymphoid compartment has not been identified. Here we report that HSCs expressing junctional adhesi
Externí odkaz:
https://doaj.org/article/c169896d54d5461da277e00c875cf3ec
Publikováno v:
International Journal of Hematology. 115:481-488
Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. Con
Publikováno v:
Human Cell. 35:408-417
Ex vivo manufactured red blood cells (RBC) generated from immortalized erythroid cell lines which can continuously grow are expected to become a significant alternative in future transfusion therapies. The ectopic expression of human papilloma virus
Autor:
Kenichi, Miharada
Publikováno v:
[Rinsho ketsueki] The Japanese journal of clinical hematology. 63(9)
Protein production is tightly regulated in cells because the accumulation of un-/misfolded proteins triggers cellular responses, particularly in the endoplasmic reticulum (ER). Recently, several studies have reported the implications of unfolded prot
Autor:
Svetlana Soboleva, Kenichi Miharada
Publikováno v:
International journal of hematology. 116(2)
Enucleation is a crucial event during the erythropoiesis, implicating drastic morphologic and transcriptomic/proteomic changes. While many genes deletion lead to failed or impaired enucleation have been identified, directly triggering the erythroid m
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1381-1392 (2014)
Developmental pluripotency-associated 5 (Dppa5) is an RNA binding protein highly expressed in undifferentiated pluripotent stem cells. Here, we demonstrate that Dppa5 is a regulator of hematopoietic stem cells (HSCs) that critically governs reconstit
Externí odkaz:
https://doaj.org/article/ef23f5144ffb4aea81d83b5cd80a1208