Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kenian, Chen"'
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
Autor:
Yichi Zhang, Matthieu Dos Santos, Huocong Huang, Kenian Chen, Puneeth Iyengar, Rodney Infante, Patricio M. Polanco, Rolf A. Brekken, Chunyu Cai, Ambar Caijgas, Karla Cano Hernandez, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114587- (2024)
Summary: Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscle
Externí odkaz:
https://doaj.org/article/178060e694dc445f9c9795570d7dc38d
Publikováno v:
Genes and Diseases, Vol 11, Iss 4, Pp 101019- (2024)
Tendon injuries often lead to joint dysfunction due to the limited self-regeneration capacity of tendons. Repairing tendons is a major challenge for surgeons and imposes a significant financial burden on society. Therefore, there is an urgent need to
Externí odkaz:
https://doaj.org/article/8b0352c8caad4b7e9725db21de050586
Autor:
Buse Eglenen-Polat, Ryan R. Kowash, Hai-Cheng Huang, Silvia Siteni, Mingrui Zhu, Kenian Chen, Matthew E. Bender, Ilgen Mender, Victor Stastny, Benjamin J. Drapkin, Prithvi Raj, John D. Minna, Lin Xu, Jerry W. Shay, Esra A. Akbay
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract There are few effective treatments for small cell lung cancer (SCLC) underscoring the need for innovative therapeutic approaches. This study focuses on exploiting telomerase, a critical SCLC dependency as a therapeutic target. A prominent ch
Externí odkaz:
https://doaj.org/article/d143811484044c1b88f499b5d0432d04
Autor:
Matthieu Dos Santos, Akansha M. Shah, Yichi Zhang, Svetlana Bezprozvannaya, Kenian Chen, Lin Xu, Weichun Lin, John R. McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer stage-specific myofiber properties remain unknown. To decipher these distinctive gene programs a
Externí odkaz:
https://doaj.org/article/be1965dd27c140d994a010d7e4345d38
Autor:
Andreas C. Chai, Francesco Chemello, Hui Li, Takahiko Nishiyama, Kenian Chen, Yu Zhang, Efraín Sánchez-Ortiz, Adeeb Alomar, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 522-535 (2023)
Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disease of progressive muscle weakness and wasting caused by the absence of dystrophin protein. Current gene therapy approaches using antisense oligonucleotides require lifelong dosing a
Externí odkaz:
https://doaj.org/article/ceeab5a0e2ca4e8485c28a7ea3202410
Autor:
Yichi Zhang, Andres Ramirez-Martinez, Kenian Chen, John R. McAnally, Chunyu Cai, Mateusz Z. Durbacz, Francesco Chemello, Zhaoning Wang, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of the nuclear
Externí odkaz:
https://doaj.org/article/089e6d82f4e743d5a199cbe608f89e95
Autor:
Miao Cui, Ayhan Atmanli, Maria Gabriela Morales, Wei Tan, Kenian Chen, Xue Xiao, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Following injury, cells in regenerative tissues can regrow, but how they adapt to injury conditions to regenerate the tissue is unclear. Here the authors identify a stress-responsive and cardioprotective factor Nrf1 that is critical for neonatal hear
Externí odkaz:
https://doaj.org/article/89eb90c4780e4ba9b3c7d007980a5bab
Autor:
Jingjing Xie, Xun Gui, Mi Deng, Heyu Chen, Yuanzhi Chen, Xiaoye Liu, Zhiqiang Ku, Lingxiao Tan, Ryan Huang, Yubo He, Bruce Zhang, Cheryl Lewis, Kenian Chen, Lin Xu, Jian Xu, Tao Huang, X. Charlene Liao, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The current immune checkpoint blockade therapy has been successful in treating some cancers but not others. New molecular targets and therapeutic approaches of cancer immunology need to be identified. Leukocyte associated immunoglobulin like receptor
Externí odkaz:
https://doaj.org/article/6d65a3dbcada490eaa67ace0038064dd
Autor:
Andres Ramirez-Martinez, Yichi Zhang, Kenian Chen, Jiwoong Kim, Bercin K. Cenik, John R. McAnally, Chunyu Cai, John M. Shelton, Jian Huang, Ana Brennan, Bret M. Evers, Pradeep P. A. Mammen, Lin Xu, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery
Externí odkaz:
https://doaj.org/article/3a056dc3d882494d8fb0ecf911b951c9
Autor:
Simon Lebek, Francesco Chemello, Xurde M. Caravia, Wei Tan, Hui Li, Kenian Chen, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson
Publikováno v:
Science
CRISPR-Cas9 gene editing is emerging as a prospective therapy for genomic mutations. However, current editing approaches are directed primarily toward relatively small cohorts of patients with specific mutations. Here, we describe a cardioprotective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402d870fc9856a5f74044d83736b3486
https://doi.org/10.1126/science.ade1105
https://doi.org/10.1126/science.ade1105