Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Keni, Ni"'
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207750 (2018)
N-(4-fluorophenyl)-N'-phenyl-N"-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine [ASP2905] is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3) that was originally identified in our laboratory. K
Externí odkaz:
https://doaj.org/article/38a206c90be04ef7be8dcb21bdfcf682
Publikováno v:
Behavioural brain research. 378
Schizophrenia is a major psychiatric disorder associated with positive and negative symptoms and cognitive impairments. In this study, we used animal models of behavior to evaluate the antipsychotic activity of ASP2905, a potent and selective inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ed7eb94b8bcf194845e0ee1808811
https://pubmed.ncbi.nlm.nih.gov/31654662
https://pubmed.ncbi.nlm.nih.gov/31654662
Autor:
Junko Yarimizu, Yasuyuki Mitani, Yoshitsugu Shitaka, Keni Ni, Mayuko Okabe, Nobuya Matsuoka, Noritoshi Ishikawa, Makoto Asai, Shingo Yamasaki, Hiroshi Uchino, Kyoko Saita, Takashi Nozawa, Hiroki Akashiba
Publikováno v:
Neuropharmacology. 79:412-419
γ-Secretase is the enzyme responsible for the intramembranous proteolysis of various substrates, such as amyloid precursor protein (APP) and Notch. Amyloid-β peptide 42 (Aβ42) is produced through the sequential proteolytic cleavage of APP by β- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d1326744635f86bf4ff6bfa68ae077
https://doi.org/10.1016/j.neuropharm.2013.12.013
https://doi.org/10.1016/j.neuropharm.2013.12.013
Autor:
Toritsuka, Michihiro, Kimoto, Sohei, Muraki, Kazue, Landek-Salgado, Melissa A, Yoshida, Atsuhiro, Yamamoto, Norio, Horiuchi, Yasue, Hiyama, Hideki, Tajinda, Katsunori, Keni, Ni, Illingworth, Elizabeth, Iwamoto, Takashi, Kishimoto, Toshifumi, Sawa, Akira, Tanigaki, Kenji
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America Vol. No. p.. 110(43):17552-17557
22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the current diagnostic categorization. However, it remains elusive how the chromosomal microdeletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::34290f64c62c770324da2d274229bf8a
http://hdl.handle.net/10564/2716
http://hdl.handle.net/10564/2716
Autor:
Yasuyuki Mitani, Yoshitsugu Shitaka, Nobuya Matsuoka, Junko Yarimizu, Keni Ni, Hiroki Akashiba
Publikováno v:
Journal of Neurochemistry. 125:465-472
Given that amyloid-β 42 (Aβ42) is believed to be a culprit in Alzheimer's disease (AD), reducing Aβ42 production should be a potential therapeutic approach. γ-Secretase modulators (GSMs) cause selective reduction of Aβ42 or both reduction of Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d12a5b1fe356df46ebe12fa41bddfd5
https://doi.org/10.1111/jnc.12125
https://doi.org/10.1111/jnc.12125
Publikováno v:
European journal of pharmacology. 810
KCNH3 (BEC1) is a member of the ether-a-go-go (KCNH) family of voltage-gated K+ channels. The aim of this study was to determine the pharmacological profiles in vitro and in vivo of a KCNH3 inhibitor N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd87a8f45204145bbd4af8a81170fc7
https://pubmed.ncbi.nlm.nih.gov/28552344
https://pubmed.ncbi.nlm.nih.gov/28552344
Autor:
Katsuya Harada, Miwako Shobo, Hiroshi Yamada, Keni Ni, Takuma Mihara, Yuji Kondo, Yukihiko Kayama, Megumi Irie, Nobuya Matsuoka
Publikováno v:
Behavioural Brain Research. 216:561-568
Body weight gain is one of the most serious side effects associated with clinical use of antipsychotics. However, the mechanisms by which antipsychotics induce body weight gain are unknown, and no reliable animal models of antipsychotics-induced weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da69bb613747a3e2612a81b1427f549
https://doi.org/10.1016/j.bbr.2010.08.046
https://doi.org/10.1016/j.bbr.2010.08.046
Autor:
Katsuya Harada, Noriyuki Yamamoto, Miwako Shobo, Masaaki Katsuoka, Yuji Kondo, Nobuya Matsuoka, Takuma Mihara, Hiroshi Yamada, Keni Ni
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:772-781
The antipsychotic drug zotepine [ZTP; 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethan-1-amine] is known to have not only atypical antipsychotic effects but also antidepressive effects in schizophrenia patients. Norzotepine [norZTP; N-des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf9582be2c9588979e185116da0fa3f
https://doi.org/10.1124/jpet.110.166264
https://doi.org/10.1124/jpet.110.166264
Autor:
Yasuyuki Mitani, Yoshitsugu Shitaka, Hiroshi Uchino, Keni Ni, Junko Yarimizu, Kyoko Saita, Hiroki Akashiba, Nobuya Matsuoka
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(6)
γ-Secretase inhibitors (GSIs) reduce amyloid-β (Aβ) peptides but inevitably increase the β-C-terminal fragment (β-CTF) of amyloid precursor protein (APP), potentially having undesirable effects on synapses. In contrast, γ-secretase modulators (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4862f6ba722365ffd10b683e6b180a2
https://pubmed.ncbi.nlm.nih.gov/22323718
https://pubmed.ncbi.nlm.nih.gov/22323718
Autor:
Yuichiro Sato, Hitoshi Doihara, Mayako Yamazaki, Masaki Aota, Junko Yarimizu, Kyoko Saita, Masahiko Morita, Kazuhiro Nakato, Katsuya Harada, Shinji Takahashi, Takayuki Yamaji, Nobuya Matsuoka, Keni Ni
Publikováno v:
European journal of pharmacology. 685(1-3)
Hypofunction of brain N-methyl- d -aspartate (NMDA) receptors has been implicated in psychiatric disorders such as schizophrenia and Alzheimer's disease. Inhibition of glycine transporter-1 (GlyT1) is expected to increase glycine, a co-agonist of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb60313b8f4c34debcf0ef0929a9e56
https://pubmed.ncbi.nlm.nih.gov/22542656
https://pubmed.ncbi.nlm.nih.gov/22542656