Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kengo, Miyata"'
Autor:
Kengo Miyata, Takashi Iwanaga, Koichi Omura, Keisuke Motoki, Seiichi Kobashi, Katsuhiro Yamano
Publikováno v:
Drug Metabolism and Disposition. 49:1016-1024
Dotinurad, a novel selective urate reabsorption inhibitor, is used to treat hyperuricemia. In humans, orally administered dotinurad is excreted mainly as glucuronide and sulfate conjugates in urine. To identify the isoforms of UDP-glucuronosyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2cadb59a775aa39567610b9d0e0b55
https://doi.org/10.1124/dmd.120.000251
https://doi.org/10.1124/dmd.120.000251
Autor:
Junichiro Uda, Tomomitsu Sasaki, Seiichi Kobashi, Takashi Iwanaga, Masahiko Fushimi, Tetsuo Ohashi, Azusa Ito, Kengo Miyata, Koichi Omura
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:313-320
Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0997f6717f192b86434b9b73b894e0ea
https://doi.org/10.1016/j.dmpk.2020.03.002
https://doi.org/10.1016/j.dmpk.2020.03.002
Publikováno v:
Tetrahedron. 76:130888
Carroll-rearrangement-type intramolecular decarboxylative allylation of β-keto allyl esters with a cationic CpRu complex bearing a chiral bisamidine-type bidentate ligand is reported. The catalytic system allows the efficient transformation of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7fa5f91d6c985b8fc73cda740407ee5
https://doi.org/10.1016/j.tet.2019.130888
https://doi.org/10.1016/j.tet.2019.130888
Autor:
Kengo Miyata, Tomohiko Muranaka
Publikováno v:
The Japanese Journal of Special Education. 54:87-99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374b93e6d1f42b9ac23295519cdff2bc
https://doi.org/10.6033/tokkyou.54.87
https://doi.org/10.6033/tokkyou.54.87
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4277-4284
Spirocyclic benzopyrans 2 interact with high affinity and selectivity with σ1 receptors. Bioisosteric replacement of the benzene ring of the benzopyran substructure with the electron rich thiophene ring (3) led to increased σ1 affinity. Herein the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dcf6742b5a87f140c502df8a68ec0d1
https://doi.org/10.1016/j.bmc.2014.05.033
https://doi.org/10.1016/j.bmc.2014.05.033
Publikováno v:
European Journal of Medicinal Chemistry. 83:709-716
In order to investigate systematically the effect of the position of the pyridine N-atom on the σ1 receptor affinity four regioisomeric furopyridines 2a–d were synthesized and pharmacologically evaluated. The key steps of the synthesis comprise br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbe6cb21b722e8ce64024c8db3881b4
https://doi.org/10.1016/j.ejmech.2014.06.073
https://doi.org/10.1016/j.ejmech.2014.06.073
Publikováno v:
Pure & Applied Chemistry. 2013, Vol. 85 Issue 6, p1121-1132. 11p.
Publikováno v:
Pure and Applied Chemistry. 85:1121-1132
Asymmetric Tsuji–Trost allylation is one of the key chiral technologies for construction of pharmaceutically important compounds because of the high utility of alkenyl-substituted products. Particularly, the dehydrative system using allylic alcohol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97d5e37e68ce03d14070ca64b985234
https://doi.org/10.1351/pac-con-12-10-02
https://doi.org/10.1351/pac-con-12-10-02
Autor:
Kengo Miyata, Masato Kitamura
Publikováno v:
Synthesis. 44:2138-2146
( S , S )- or ( R , R )-Naph-diPIM-dioxo- i -Pr–CpRu(II) complex with a Bronsted acid catalyzes dehydrative intermolecular C-allylation with high enantio- and regioselectivity. The new soft Ru/hard H + combined catalyst can also be used for intramo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb14692d54a99d805ba14498f12437c8
https://doi.org/10.1055/s-0031-1290301
https://doi.org/10.1055/s-0031-1290301
Autor:
Tomohiko, Muranaka, Kengo, Miyata
Publikováno v:
上越教育大学特別支援教育実践研究センター紀要. 18:9-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::8a58f31befab5a00a035043f9145bfed
http://hdl.handle.net/10513/1505
http://hdl.handle.net/10513/1505