Zobrazeno 1 - 10
of 426
pro vyhledávání: '"Kengo, Ito"'
Autor:
Yoshiki Niimi, Shorena Janelidze, Kenichiro Sato, Naoki Tomita, Tadashi Tsukamoto, Takashi Kato, Kenji Yoshiyama, Hisatomo Kowa, Atsushi Iwata, Ryoko Ihara, Kazushi Suzuki, Kensaku Kasuga, Takeshi Ikeuchi, Kenji Ishii, Kengo Ito, Akinori Nakamura, Michio Senda, Theresa A. Day, Samantha C. Burnham, Leonardo Iaccarino, Michael J. Pontecorvo, Oskar Hansson, Takeshi Iwatsubo
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Maximizing the efficiency to screen amyloid-positive individuals in asymptomatic and non-demented aged population using blood-based biomarkers is essential for future success of clinical trials in the early stage of Alzheimer’s
Externí odkaz:
https://doaj.org/article/d12e8157ca6b40da9d6b4f81cfd4802f
Autor:
Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, Atsushi Watanabe, Kensaku Kasuga, Takeshi Ikeuchi, Akinori Takeda, Takashi Sakurai, Kengo Ito, Takashi Kato
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100795- (2024)
Background: Positron emission tomography, which assesses the binding of translocator protein radiotracers, 11C-DPA-713, may be a sensitive method for determining glial-mediated neuroinflammation levels. This study investigated the relationship betwee
Externí odkaz:
https://doaj.org/article/63591186049c4e31b0fae6bfd1a53d77
Autor:
Takashi Nihashi, Keita Sakurai, Takashi Kato, Yasuyuki Kimura, Kengo Ito, Akinori Nakamura, Teruhiko Terasawa
Publikováno v:
Diagnostic and Prognostic Research, Vol 8, Iss 1, Pp 1-8 (2024)
Abstract Background There is urgent clinical need to identify reliable prognostic biomarkers that predict the progression of dementia symptoms in individuals with early-phase Alzheimer’s disease (AD) especially given the research on and predicted a
Externí odkaz:
https://doaj.org/article/ac3a08ee49d44ba7be3dbc72eb69c838
Autor:
Takayuki Sakai, Aya Ogata, Hiroshi Ikenuma, Takashi Yamada, Saori Hattori, Junichiro Abe, Shinichi Imamura, Masanori Ichise, Mari Tada, Akiyoshi Kakita, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, Kengo Ito, Yasuyuki Kimura
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Background Heat shock proteins (HSPs) are present throughout the brain. They function as molecular chaperones, meaning they help with the folding and unfolding of large protein complexes. These chaperones are vital in the development of neur
Externí odkaz:
https://doaj.org/article/7e5c56ae5ca04ac88d65512c7d7c7460
Autor:
Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, Junichiro Abe, Chie Seki, Yuji Nagai, Masanori Ichise, Takafumi Minamimoto, Makoto Higuchi, Ming-Rong Zhang, Takashi Kato, Kengo Ito, Masaaki Suzuki, Yasuyuki Kimura
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Background Receptor interacting protein kinase 1 (RIPK1) is a serine/threonine kinase, which regulates programmed cell death and inflammation. Recently, the involvement of RIPK1 in the pathophysiology of Alzheimer’s disease (AD) has been r
Externí odkaz:
https://doaj.org/article/cfeab7411ca541868cfb1ec34b86e244
Publikováno v:
Metabolites, Vol 14, Iss 7, p 391 (2024)
Fermentation—a process of compound degradation by microorganisms—is a traditional food processing method utilized worldwide for the long-term preservation of fresh foods. In recent years, fermented foods have gained attention as health foods. Fer
Externí odkaz:
https://doaj.org/article/d4d307478304497391f193ea1f9d41eb
Autor:
Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, Yasuyuki Kimura
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Background The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection areas such as the hipp
Externí odkaz:
https://doaj.org/article/346ec729b0b946fc8cbdb93e87ecc3c2
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-5 (2023)
Abstract Background This study aimed to identify the appropriate computer-based cognitive tests and cut-off values for estimating amyloid burden in preclinical Alzheimer’s disease drug trials. Methods Data from 103 older individuals, who underwent
Externí odkaz:
https://doaj.org/article/8b1c9e3e6a804bc9933979f2fce89afb
Autor:
Shohei Tanaka, Noriyuki Kadoya, Yuto Sugai, Mariko Umeda, Miyu Ishizawa, Yoshiyuki Katsuta, Kengo Ito, Ken Takeda, Keiichi Jingu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Early regression—the regression in tumor volume during the initial phase of radiotherapy (approximately 2 weeks after treatment initiation)—is a common occurrence during radiotherapy. This rapid radiation-induced tumor regression may alt
Externí odkaz:
https://doaj.org/article/3249c9ff1d1c44e3a008bbcacdfbc949
Autor:
Fumihiko Yasuno, Atsushi Watanabe, Yasuyuki Kimura, Yumeka Yamauchi, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, Kensaku Kasuga, Takeshi Ikeuchi, Akinori Takeda, Takashi Sakurai, Kengo Ito, Takashi Kato
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100549- (2022)
Background: Neuroinflammation is a well-known feature of Alzheimer’s disease (AD), and a blood-based test for estimating the levels of neuroinflammation would be expected. In this study, we examined and validated a model using blood-based biomarker
Externí odkaz:
https://doaj.org/article/7e61e200b385413a970212963230dc5d