Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension.

Autor: Marta Perez, Keng Jin Lee, Herminio J Cardona, Joann M Taylor, Mary E Robbins, Gregory B Waypa, Sara K Berkelhamer, Kathryn N Farrow

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0180957 (2017)

Bronchopulmonary dysplasia (BPD), a common complication of preterm birth, is associated with pulmonary hypertension (PH) in 25% of infants with moderate to severe BPD. Neonatal mice exposed to hyperoxia for 14d develop lung disease similar to BPD, wi

Externí odkaz: https://doaj.org/article/6d0726218e2a4eaa9e7fed304d3f1168

SOD2 Activity Is not Impacted by Hyperoxia in Murine Neonatal Pulmonary Artery Smooth Muscle Cells and Mice

Autor: Joann M. Taylor, Kathryn N. Farrow, Marta Perez, Keng Jin Lee, Anita Gupta

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 3, Pp 6373-6390 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 3
Pages 6373-6390

Pulmonary hypertension (PH) complicates bronchopulmonary dysplasia (BPD) in 25% of infants. Superoxide dismutase 2 (SOD2) is an endogenous mitochondrial antioxidant, and overexpression protects against acute lung injury in adult mice. Little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b679252cb574f2ab264f79c4417a8214
http://www.mdpi.com/1422-0067/16/3/6373

Aberrant cGMP signaling persists during recovery in mice with oxygen-induced pulmonary hypertension

Autor: Gregory B. Waypa, Keng Jin Lee, Mary E. Robbins, Herminio J. Cardona, Joann M. Taylor, Sara K. Berkelhamer, Marta Perez, Kathryn N. Farrow

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0180957 (2017)

Bronchopulmonary dysplasia (BPD), a common complication of preterm birth, is associated with pulmonary hypertension (PH) in 25% of infants with moderate to severe BPD. Neonatal mice exposed to hyperoxia for 14d develop lung disease similar to BPD, wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d56e37cf49cf43c44a01f55187b8540
https://pubmed.ncbi.nlm.nih.gov/28792962

Right ventricular cyclic nucleotide signaling is decreased in hyperoxia-induced pulmonary hypertension in neonatal mice

Autor: Megan B Lagoski, Joann M. Taylor, Sara K. Berkelhamer, Keng Jin Lee, Robin H. Steinhorn, Kathryn N. Farrow, Gina A. Kim, Rachel Purdy Heilman

Publikováno v: American journal of physiology. Heart and circulatory physiology. 308(12)

Pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) affect 25–35% of premature infants with significant bronchopulmonary dysplasia (BPD), increasing morbidity and mortality. We sought to determine the role of phosphodiesterase 5 (PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ef6bc39a3db3368d0eaf389dc72000
https://pubmed.ncbi.nlm.nih.gov/25862831

Cadherin Point Mutations Alter Cell Sorting and Modulate GTPase Signaling

Autor: Shaoying Lu, Deborah E. Leckband, Matthew D. Langer, Quanming Shi, Hamid Tabdili, Adrienne K. Barry, Yuan Hung Chien, Keng Jin Lee

Publikováno v: Journal of Cell Science.

This study investigated the impact of cadherin binding differences on both cell sorting and GTPase activation. The use of N-terminal domain point mutants of Xenopus C-cadherin enabled us to quantify binding differences and determine their effects on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b6ecc1dcb5ce8f3de42a84bd000d3c
https://doi.org/10.1242/jcs.087395