Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kenea C. Udobi"'
Autor:
Nicholas Delcimmuto, Matthew R. Skelton, Kenea C. Udobi, Zuhair I. Abdulla, Amanda N. Kokenge, Marla K. Perna
Publikováno v:
J Inherit Metab Dis
Creatine (Cr) is a guanidino compound that provides readily-available phosphate pools for the regeneration of spent ATP. The lack of brain Cr causes moderate to severe intellectual disability, language impairment, and epilepsy. The most prevalent cau
Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice
Autor:
Kim B. Seroogy, Matthew R. Skelton, Kenea C. Udobi, Kerstin H. Lundgren, Bahar Pahlevani, Zuhair I. Abdulla, Jordan L. Pennington
Publikováno v:
J Mol Neurosci
The lack of cerebral creatine (Cr) causes intellectual disability and epilepsy. In addition, a significant portion of individuals with Cr transporter (Crt) deficiency (CTD), the leading cause of cerebral Cr deficiency syndromes (CCDS), are diagnosed
Autor:
Matthew R. Skelton, Pascale de Lonlay, Alain Pruvost, Aloïse Mabondzo, Frédéric Taran, Sophie Dezard, Gabriela Ullio-Gamboa, Narciso Costa, Jean-Pierre Benoit, Keila N. Miles, Marla K. Perna, Kenea C. Udobi
Publikováno v:
Nanomedicine (London, England)
Nanomedicine (London, England), 2019, 14 (12), pp.1579-1593. ⟨10.2217/nnm-2019-0059⟩
Nanomedicine (Lond)
Nanomedicine (London, England), 2019, 14 (12), pp.1579-1593. ⟨10.2217/nnm-2019-0059⟩
Nanomedicine (Lond)
Creatine transporter (CrT) deficiency is an X-linked intellectual disability caused by mutations of CrT. Aim: This work focus on the preclinical development of a new therapeutic approach based on a microemulsion (ME) as drug delivery system for dodec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbb99fa342182a6571bfdb70d2ae06d
https://hal.univ-angers.fr/hal-02616077
https://hal.univ-angers.fr/hal-02616077
Autor:
Kenea C. Udobi, Matthew R. Skelton, Keila N. Miles, Amanda N. Kokenge, Marla K. Perna, Gail J. Pyne-Geithman, Joseph F. Clark, Zaza Khuchua
Publikováno v:
Amino Acids. 48:2057-2065
Creatine (Cr) is a guanidino compound required for rapid replenishment of ATP in cells with a high-energy demand. In humans, mutations in the Cr transporter (CRT;SLC6A8) prevent Cr entry into tissue and result in a significant intellectual impairment
Autor:
Michael T. Williams, Amanda N. Kokenge, Charles V. Vorhees, Emily R. Hautman, Matthew R. Skelton, Kenea C. Udobi
Publikováno v:
Journal of Inherited Metabolic Disease. 37:63-68
Creatine transporter (CrT) deficiency (CTD) is an X-linked disorder characterized by intellectual disability and speech delay. There have been reports that show female carriers have clinical symptoms. We have created CrT knockout (CrT(−/y)) mice in
Autor:
Kenea C. Udobi, Michael T. Williams, Aloïse Mabondzo, Amanda N. Kokenge, Julie Coene, Charles V. Vorhees, Emily R. Hautman, Matthew R. Skelton, Gabriela Ullo
Publikováno v:
Genes, Brain and Behavior. 17:e12461
Creatine transporter (CrT; SLC6A8) deficiency (CTD) is an X-linked disorder characterized by severe cognitive deficits, impairments in language, and an absence of brain creatine (Cr). In a previous study, we generated floxed Slc6a8 (Slc6a8flox) mice