Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kendra Marcus"'
Autor:
Subu Subramanian, Kent Gorday, Kendra Marcus, Matthew R Orellana, Peter Ren, Xiao Ran Luo, Michael E O'Donnell, John Kuriyan
Publikováno v:
eLife, Vol 10 (2021)
Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in catalysis or binding display re
Externí odkaz:
https://doaj.org/article/e3ba2e767c774bfb9759eabd614c6afb
Autor:
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T. Brunger
Publikováno v:
bioRxiv
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the viral spike glycoprotein. Hence, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ff3f156726e60f7df4ce4c7d4fff23
https://doi.org/10.1073/pnas.2210990119
https://doi.org/10.1073/pnas.2210990119
Autor:
Carla Mattos, Kendra Marcus
Publikováno v:
Journal of Computational Chemistry. 41:402-414
The Ras GTPase superfamily of proteins coordinates a diverse set of cellular outcomes, including cell morphology, vesicle transport, and cell proliferation. Primary amino acid sequence analysis has identified Specificity determinant positions (SDPs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a745f8b40b06ac817abe1e07f9872f90
https://doi.org/10.1002/jcc.26060
https://doi.org/10.1002/jcc.26060
Autor:
Michelle Dechene, Kendra Marcus, Bradley M. Kearney, Michael Schwabe, Daniel M. Roberts, Paul Swartz, Carla Mattos
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 88:152-165
Water and ligand binding play critical roles in the structure and function of proteins, yet their binding sites and significance are difficult to predict a priori. Multiple solvent crystal structures (MSCS) is a method where several X-ray crystal str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ad218495caeab5c3e1b0560a89b438
https://doi.org/10.1002/prot.25781
https://doi.org/10.1002/prot.25781
Autor:
Hyunbum Jang, Avik Banerjee, Lee Makowski, Carla Mattos, Kendra Marcus, Ruth Nussinov, Monica Ojeda, Vadim Gaponenko
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b516b93326583e19fee6ae0d3e4d51
https://doi.org/10.1096/fasebj.2021.35.s1.04058
https://doi.org/10.1096/fasebj.2021.35.s1.04058
Autor:
Kent Gorday, John Kuriyan, Subu Subramanian, Matthew R Orellana, Peter Ren, Kendra Marcus, Xiao Ran Luo, Mike O'Donnell
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in catalysis or binding display re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c8dabca502b35c53c8837a59bed4c
https://pubmed.ncbi.nlm.nih.gov/33847559
https://pubmed.ncbi.nlm.nih.gov/33847559
Autor:
Ruth Nussinov, Kendra Marcus, Vadim Gaponenko, Hyunbum Jang, Carla Mattos, Lee Makowski, Avik Banerjee
Publikováno v:
SSRN Electronic Journal.
Ca2+-CaM extracts KRas4B from the plasma membrane, suggesting that KRas4B–CaM interaction plays a role in regulating Ras signaling. To gain mechanistic insight, we provide a computational model, supported by experimental structural data, of farnesy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd60cab826b1025d66ade18583cf126
https://doi.org/10.2139/ssrn.3417943
https://doi.org/10.2139/ssrn.3417943
Autor:
Carla Mattos, Kendra Marcus
Publikováno v:
Clinical Cancer Research. 21:1810-1818
The crystal structure of RAS was first solved 25 years ago. In spite of tremendous and sustained efforts, there are still no drugs in the clinic that directly target this major driver of human cancers. Recent success in the discovery of compounds tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9fa9b62828f240da1083b258f13740
https://doi.org/10.1158/1078-0432.ccr-14-2148
https://doi.org/10.1158/1078-0432.ccr-14-2148
Autor:
Hyunbum Jang, Ruth Nussinov, Carla Mattos, Lee Makowski, Kendra Marcus, Avik Banerjee, Vadim Gaponenko
Publikováno v:
Structure. 27:1647-1659.e4
Ca2+-calmodulin (CaM) extracts KRas4B from the plasma membrane, suggesting that KRas4B/CaM interaction plays a role in regulating Ras signaling. To gain mechanistic insight, we provide a computational model, supported by experimental structural data,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75fa4aeaf3e5bc741b99ff9b2880ed2
https://doi.org/10.1016/j.str.2019.08.009
https://doi.org/10.1016/j.str.2019.08.009