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pro vyhledávání: '"Kendra M. Fleming"'
Publikováno v:
Nutrients; Volume 15; Issue 11; Pages: 2494
Obesity, a known risk factor of Alzheimer’s disease (AD), increases the activation of microglia, leading to a proinflammatory phenotype. Our previous work shows that a high fat diet (HFD) can cause neuroinflammation and cognitive decline in mice. W
Autor:
Simon W. So, Kendra M. Fleming, Cayla M. Duffy, Joshua P. Nixon, David A. Bernlohr, Tammy A. Butterick
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4354
The microglial fatty-acid-binding protein 4-uncoupling protein 2 (FABP4-UCP2) axis is a key regulator of neuroinflammation in high-fat-diet (HFD)-fed animals, indicating a role for FABP4 in brain immune response. We hypothesized that the FABP4-UCP2 a