Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kendra L. Puig"'
Autor:
Sarah Noureddine, Tatiana Saccon, Trina Rudeski-Rohr, Adam Gesing, Jeffrey B. Mason, Augusto Schneider, Joseph Dhabhi, Kendra L. Puig, Sharlene Rakoczy, Holly M. Brown-Borg, Michal M. Masternak
Publikováno v:
GeroScience
Alzheimer’s disease (AD) is the most common form of dementia, affecting approximately 6.5 million Americans age 65 or older. AD is characterized by increased cognitive impairment and treatment options available provide minimal disease attenuation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e478637e10a18d88113be9f65cd7d5
https://pubmed.ncbi.nlm.nih.gov/35900661
https://pubmed.ncbi.nlm.nih.gov/35900661
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127102 (2015)
Exposure to air pollutants, including particulate matter, results in activation of the brain inflammatory response and Alzheimer disease (AD)-like pathology in dogs and humans. However, the length of time required for inhalation of ambient particulat
Externí odkaz:
https://doaj.org/article/5553fc1c7214448ba7b806c9bebec74e
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119534 (2015)
Although APP and its proteolytic metabolites have been well examined in the central nervous system, there remains limited information of their functions outside of the brain. For example, amyloid precursor protein (APP) and amyloid beta (Aβ) immunor
Externí odkaz:
https://doaj.org/article/8867c00c033e4b0fae9fb613a5cd48b0
Autor:
Gunjan D Manocha, Kendra L Puig, Susan A Austin, Kathleen Seyb, Marcie A Glicksman, Colin K Combs
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132604 (2015)
Microgliosis is a major hallmark of Alzheimer's disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion of pro-inflammatory cytokines
Externí odkaz:
https://doaj.org/article/c21cbb7268354f038118ef7f877edbb9
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30378 (2012)
Middle age obesity is recognized as a risk factor for Alzheimer's disease (AD) although a mechanistic linkage remains unclear. Based upon the fact that obese adipose tissue and AD brains are both areas of proinflammatory change, a possible common eve
Externí odkaz:
https://doaj.org/article/92922479f4e24d96a7020291dc98ebc3
Autor:
Joshua A. Kulas, Matthew W. Gorr, Kendra L. Puig, Michael P. McDonald, Colin K. Combs, Justine E. Melvin, Jordan V. Hettwer, Vineeta Tanwar, Loren E. Wold, Mona Sohrabi, Gunjan D. Manocha
Publikováno v:
Environmental Pollution. 241:279-288
Environmental exposure to air pollution has been linked to a number of health problems including organ rejection, lung damage and inflammation. While the deleterious effects of air pollution in adult animals are well documented, the long-term consequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c182e84b63d9b009004cc55de43825a0
https://doi.org/10.1016/j.envpol.2018.05.047
https://doi.org/10.1016/j.envpol.2018.05.047
Publikováno v:
Current Alzheimer Research
Background: Alzheimer’s disease (AD) is associated with age-associated central nervous system degeneration and dementia. This decline in the function correlates with deposition of Aβ peptide containing plaques and associated reactive gliosis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4742092dfe2f3e2eddae540b22fda082
https://doi.org/10.2174/1567205015666180801111033
https://doi.org/10.2174/1567205015666180801111033
Autor:
Colin K. Combs, Christopher M. Norris, Kendra L. Puig, Atreyi Ghatak, Susan D. Kraner, Gunjan D. Manocha
Publikováno v:
Journal of Alzheimer's Disease. 58:775-787
Alzheimer's disease (AD) brains are characterized by fibrillar amyloid-β (Aβ) peptide containing plaques and associated reactive microglia. The proinflammatory phenotype of the microglia suggests that they may negatively affect disease course and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d4605e01aa19dfb74cf3d1bf0fcc2e
https://doi.org/10.3233/jad-151203
https://doi.org/10.3233/jad-151203
Autor:
Kendra L. Puig, Keiko Rausch, Joshua A. Kulas, Brett A. McGregor, Lalida Rojanathammanee, Angela M. Floden, Colin K. Combs, Gunjan D. Manocha, Sanjib Karki, James E. Porter, Kelley R. Puig, Michael R. Nichols, Diane C. Darland
Publikováno v:
Journal of Neuroscience. 36:8471-8486
Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer9s disease. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73422e8e3021feb323eaba4868cd2e4b
https://doi.org/10.1523/jneurosci.4654-15.2016
https://doi.org/10.1523/jneurosci.4654-15.2016
Autor:
Holly M. Brown-Borg, Colin K. Combs, Kendra L. Puig, Whitney Franklin, Joshua A. Kulas, Giulio Taglialatela, Sharlene G. Rakoczy
Publikováno v:
Neurobiology of Aging. 40:22-40
APP/PS1 double transgenic mice expressing human mutant amyloid precursor protein (APP) and presenilin-1 (PS-1) demonstrate robust brain Aβ peptide containing plaque deposition, increased markers of oxidative stress, behavioral dysfunction, and proin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979805e716a05e098c014403e67764c9
https://doi.org/10.1016/j.neurobiolaging.2015.12.021
https://doi.org/10.1016/j.neurobiolaging.2015.12.021