Výsledky vyhledávání - "Kendra L. Hailey"

Akademický článek

Geometrical Frustration in Interleukin-33 Decouples the Dynamics of the Functional Element from the Folding Transition State Ensemble.

Autor: Kaitlin M Fisher, Ellinor Haglund, Jeffrey K Noel, Kendra L Hailey, José N Onuchic, Patricia A Jennings

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144067 (2015)

Interleukin-33 (IL-33) is currently the focus of multiple investigations into targeting pernicious inflammatory disorders. This mediator of inflammation plays a prevalent role in chronic disorders such as asthma, rheumatoid arthritis, and progressive

Externí odkaz: https://doaj.org/article/c2885e0868f746849ed0e8c1fc4afc35

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Cigarette Smoke Triggers IL-33–associated Inflammation in a Model of Late-Stage Chronic Obstructive Pulmonary Disease

Autor: Jasmine Lee, Kendra L. Hailey, Timothy D. Bigby, Steven A. Vitorino, Ellen C. Breen, Patricia A. Jennings

Publikováno v: American journal of respiratory cell and molecular biology, vol 61, iss 5

Chronic obstructive pulmonary disease (COPD) is a worldwide threat. Cigarette smoke (CS) exposure causes cardiopulmonary disease and COPD and increases the risk for pulmonary tumors. In addition to poor lung function, patients with COPD are susceptib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476583a785694b183b4937ccb8260581
https://doi.org/10.1165/rcmb.2018-0402oc

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Redirecting SR Protein Nuclear Trafficking Through An Allosteric Platform

Autor: Laurent Fattet, Joseph A. Adams, Brandon E. Aubol, Kendra L. Hailey, Patricia A. Jennings

Publikováno v: Journal of molecular biology, vol 429, iss 14

Although phosphorylation directs serine-arginine (SR) proteins from nuclear storage speckles to the nucleoplasm for splicing function, dephosphorylation paradoxically induces similar movement, raising the question of how such chemical modifications a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf332bc62165614190beb4690df2903
https://europepmc.org/articles/PMC5536852/

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Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1

Autor: Mark L. Paddock, Ron Mittler, Rachel Nechushtai, Colin H. Lipper, Faruck Morcos, Patricia A. Jennings, Kendra L. Hailey, José N. Onuchic, Andrea R. Conlan, Assaf Friedler, Charles Wang, Chen Katz, John A. Zuris, Shahar Rotem-Bamberger, Sagi Tamir

Publikováno v: Proceedings of the National Academy of Sciences. 111:5177-5182

Life requires orchestrated control of cell proliferation, cell maintenance, and cell death. Involved in these decisions are protein complexes that assimilate a variety of inputs that report on the status of the cell and lead to an output response. Am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b8a007c256e9dcf37b8cafca1bfee6
https://doi.org/10.1073/pnas.1403770111

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Allosteric Switching of Agonist/Antagonist Activity by a Single Point Mutation in the Interluekin-1 Receptor Antagonist, IL-1Ra

Autor: Dominique T. Capraro, Patricia A. Jennings, Kendra L. Hailey, Sulyman Barkho

Publikováno v: Journal of Molecular Biology. 425:2382-2392

The pleiotropic pro-inflammatory cytokine interleukin (IL)-1β has co-evolved with a competitive inhibitor, IL-1 receptor antagonist (IL-1Ra). IL-1β initiates cell signaling by binding the IL-1 receptor (IL-1R) whereas IL-1Ra acts as an antagonist,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c470b514a8a4bbff7f28a6725938ddc0
https://doi.org/10.1016/j.jmb.2013.03.016

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Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates

Autor: Brandon E. Aubol, Malik M. Keshwani, Laurent Fattet, Joseph A. Adams, Kendra L. Hailey, Patricia A. Jennings, Maria L. McGlone

Publikováno v: The Biochemical journal, vol 472, iss 3

Phosphorylation-dependent cell communication requires enzymes that specifically recognize key proteins in a sea of similar, competing substrates. The protein kinases achieve this goal by utilizing docking grooves in the kinase domain or heterologous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaa8a69d402f3f16fc6822d04bb7abf
https://escholarship.org/uc/item/4mr327sw

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Pro-interleukin (IL)-1β Shares a Core Region of Stability as Compared with Mature IL-1β While Maintaining a Distinctly Different Configurational Landscape

Autor: Sheng Li, Patricia A. Jennings, Kendra L. Hailey, Melinda Roy, Virgil L. Woods, Mette Dahl Andersen

Publikováno v: Journal of Biological Chemistry. 284:26137-26148

Interleukin-1β (IL-1β) is a master cytokine involved in initiating the innate immune response in vertebrates (Dinarello, C. A. (1994) FASEB J. 8, 1314–1325). It is first synthesized as an inactive 269-residue precursor (pro-interleukin-1β or pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa15489ed562c4643d546a5fb5e91fb7
https://doi.org/10.1074/jbc.m109.027375

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Geometrical Frustration in Interleukin-33 Decouples the Dynamics of the Functional Element from the Folding Transition State Ensemble

Autor: Ellinor Haglund, Kaitlin M. Fisher, Jeffrey K. Noel, Kendra L. Hailey, Patricia A. Jennings, José N. Onuchic

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144067 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa44c4c803aa4f79f474ddb58e7f8611
https://doaj.org/article/c2885e0868f746849ed0e8c1fc4afc35

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Regulating SR Protein Phosphorylation Through Regions Outside the Kinase Domain of SRPK1

Autor: Sheng Li, Xiang-Dong Fu, Gourisankar Gosh, Virgil L. Woods, Chen-Ting Ma, Ryan M. Plocinik, Patricia A. Jennings, Joseph A. Adams, Jennifer Whitehouse, Kendra L. Hailey, Tong Liu

SR proteins (splicing factors containing arginine-serine repeats) are essential splicing factors whose phosphorylation by the SR-specific protein kinase (SRPK) family regulates nuclear localization and mRNA processing activity. In addition to an N-te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48eb462f487e836c076104e445a7f9a
https://europepmc.org/articles/PMC3121894/

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Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study

Autor: Kendra L, Hailey, Sheng, Li, Mette D, Andersen, Melinda, Roy, Virgil L, Woods, Patricia A, Jennings

Publikováno v: The Journal of biological chemistry. 284(38)

Interleukin-1beta (IL-1beta) is a master cytokine involved in initiating the innate immune response in vertebrates (Dinarello, C. A. (1994) FASEB J. 8, 1314-1325). It is first synthesized as an inactive 269-residue precursor (pro-interleukin-1beta or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac8630bb1a5f4b09cf9a2c3ce6216911
https://pubmed.ncbi.nlm.nih.gov/19592498

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