Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kendra L Congdon"'
Autor:
John H Sampson, Robert J Schmittling, Gary E Archer, Kendra L Congdon, Smita K Nair, Elizabeth A Reap, Annick Desjardins, Allan H Friedman, Henry S Friedman, James E Herndon, April Coan, Roger E McLendon, David A Reardon, James J Vredenburgh, Darell D Bigner, Duane A Mitchell
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31046 (2012)
Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy. How
Externí odkaz:
https://doaj.org/article/9c5a1bf348704ed5af50908203b99a21
Autor:
Adam M. Swartz, Kendra L. Congdon, Smita K. Nair, Qi-Jing Li, James E. Herndon, Carter M. Suryadevara, Katherine A. Riccione, Gary E. Archer, Pamela K. Norberg, Luis A. Sanchez-Perez, John H. Sampson
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Abstract Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response. Sev
Externí odkaz:
https://doaj.org/article/630d5dbd82df4a1bb95d08b2e6228b95
Autor:
Katherine A. Riccione, Li-Zhen He, Peter E. Fecci, Pamela K. Norberg, Carter M. Suryadevara, Adam Swartz, Patrick Healy, Elizabeth Reap, Tibor Keler, Qi-Jing Li, Kendra L. Congdon, Luis Sanchez-Perez, John H. Sampson
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
Despite their promise, tumor-specific peptide vaccines have limited efficacy. CD27 is a costimulatory molecule expressed on CD4+ and CD8+ T cells that is important in immune activation. Here we determine if a novel CD27 agonist antibody (αhCD27) can
Externí odkaz:
https://doaj.org/article/77ddcfed2cec41819fd5ac284cd5d891
Autor:
John H. Sampson, Duane A. Mitchell, Peter E. Fecci, Darell D. Bigner, Henry S. Friedman, Allan H. Friedman, Roger E. McLendon, Gordana Vlahovic, Annick Desjardins, Kent J. Weinhold, Taylor M. Broome, Anastasie M. Dunn-Pirio, Smita K. Nair, Anirudh Saraswathula, Mohammed K. Hossain-Ibrahim, John S. Yi, Katherine A. Riccione, Adam M. Swartz, Olivia C. Campbell, Patrick C. Gedeon, Kendra L. Congdon, Patrick Healy, James E. Herndon, Pamela K. Norberg, Robert J. Schmittling, Gary E. Archer, Luis Sanchez-Perez, Kristen A. Batich, Carter M. Suryadevara, Elizabeth A. Reap
Summary of adverse events with possible relation to study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6d423c21966ce90fefe65599e1ca46
https://doi.org/10.1158/0008-5472.22417785.v1
https://doi.org/10.1158/0008-5472.22417785.v1
Autor:
John H. Sampson, Duane A. Mitchell, Peter E. Fecci, Darell D. Bigner, Henry S. Friedman, Allan H. Friedman, Roger E. McLendon, Gordana Vlahovic, Annick Desjardins, Kent J. Weinhold, Taylor M. Broome, Anastasie M. Dunn-Pirio, Smita K. Nair, Anirudh Saraswathula, Mohammed K. Hossain-Ibrahim, John S. Yi, Katherine A. Riccione, Adam M. Swartz, Olivia C. Campbell, Patrick C. Gedeon, Kendra L. Congdon, Patrick Healy, James E. Herndon, Pamela K. Norberg, Robert J. Schmittling, Gary E. Archer, Luis Sanchez-Perez, Kristen A. Batich, Carter M. Suryadevara, Elizabeth A. Reap
Ex vivo analysis of CMV pp65-specific CD8+ T cells in circulation before and after immunotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ddd773de4481cf84d8cddf24412e18
https://doi.org/10.1158/0008-5472.22417791.v1
https://doi.org/10.1158/0008-5472.22417791.v1
Autor:
John H. Sampson, Duane A. Mitchell, Peter E. Fecci, Darell D. Bigner, Henry S. Friedman, Allan H. Friedman, Roger E. McLendon, Gordana Vlahovic, Annick Desjardins, Kent J. Weinhold, Taylor M. Broome, Anastasie M. Dunn-Pirio, Smita K. Nair, Anirudh Saraswathula, Mohammed K. Hossain-Ibrahim, John S. Yi, Katherine A. Riccione, Adam M. Swartz, Olivia C. Campbell, Patrick C. Gedeon, Kendra L. Congdon, Patrick Healy, James E. Herndon, Pamela K. Norberg, Robert J. Schmittling, Gary E. Archer, Luis Sanchez-Perez, Kristen A. Batich, Carter M. Suryadevara, Elizabeth A. Reap
Median survival for glioblastoma (GBM) remains ex vivo analyses from this study found no change in the capacity of CMV pp65-specific T cells to gain multiple effector functions or polyfunctionality, which has been associated with superior antitumor e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff9c63b4ce53b8abc0e4e7bd97521a
https://doi.org/10.1158/0008-5472.c.6509943.v1
https://doi.org/10.1158/0008-5472.c.6509943.v1
Publikováno v:
Pharmacol Ther
Several Phase II and III clinical trials have demonstrated that immunotherapy can induce objective responses in otherwise refractory malignancies in tumors outside the central nervous system. In large part, effector T cells mediate much of the antitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad9998b6335c27088db69384f44eeed
https://doi.org/10.1016/j.pharmthera.2018.12.007
https://doi.org/10.1016/j.pharmthera.2018.12.007
Autor:
Katherine B. Peters, Aditya Mohan, Weihua Xie, David M. Ashley, Pamela Norberg, Gary E. Archer, Elizabeth A. Reap, Gordana Vlahovic, Annick Desjardins, Kristen A. Batich, Henry S. Friedman, Denise Jaggers, Hai Yan, Mustafa Khasraw, James E. Herndon, Kendra L. Congdon, Margaret Johnson, Daniel Landi, John Sampson, Kelly Hotchkiss
Publikováno v:
Neuro-Oncology Advances. 3:iv5-iv6
INTRODUCTION While primary GBM is largely heterogeneous and devoid of homogeneously expressed neoantigens, mutant IDH1 (R132H) is a uniformly expressed hallmark in >70% of low grade gliomas. As such, IDH1 mutations represent a potentially valuable va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0bea6e3f586130bd2056fc27e8afdc
https://doi.org/10.1093/noajnl/vdab112.019
https://doi.org/10.1093/noajnl/vdab112.019
Autor:
John H. Sampson, Kendra L. Congdon, Luis Sanchez-Perez, Smita K. Nair, James E. Herndon, Gary E. Archer, Adam M. Swartz, Carter M. Suryadevara, Pamela Norberg, Qi-Jing Li, Katherine A. Riccione
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
npj Vaccines, Vol 6, Iss 1, Pp 1-7 (2021)
Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response. Several canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a0280094df4b5d2081997980447db7
http://europepmc.org/articles/PMC7814002
http://europepmc.org/articles/PMC7814002
Autor:
Olivia C. Campbell, Pamela Norberg, Gordana Vlahovic, Kendra L. Congdon, Kent J. Weinhold, Elizabeth A. Reap, Katherine A. Riccione, Adam M. Swartz, James E. Herndon, Anirudh Saraswathula, Duane Mitchell, Allan H. Friedman, Darell D. Bigner, Patrick Healy, Roger E. McLendon, John H. Sampson, Henry S. Friedman, Luis Sanchez-Perez, Peter E. Fecci, John S. Yi, Smita K. Nair, Patrick C. Gedeon, Mohammed K. Hossain-Ibrahim, Carter M. Suryadevara, Taylor M. Broome, Gary E. Archer, Annick Desjardins, Robert J. Schmittling, Anastasie Dunn-Pirio, Kristen A. Batich
Publikováno v:
Cancer Research. 78:256-264
Median survival for glioblastoma (GBM) remains Significance: A randomized pilot trial in patients with GBM implicates polyfunctional T-cell responses as a biomarker for effective antitumor immunotherapy. Cancer Res; 78(1); 256–64. ©2017 AACR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d26c35c2e1832b480f32a01d76b195
https://doi.org/10.1158/0008-5472.can-17-0469
https://doi.org/10.1158/0008-5472.can-17-0469