Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kendra K. S. Nordgren"'
Publikováno v:
Cardiovascular toxicology. 20(6)
Doxorubicin (DOX) is a widely prescribed anthracycline antineoplastic drug for treating human solid tumors and leukemias. However, DOX therapy is limited by a cumulative, dose-dependent, and irreversible cardiomyopathy that occurs with repeated admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7882197f8a7b6c34e9ec60d639466e
https://pubmed.ncbi.nlm.nih.gov/32500386
https://pubmed.ncbi.nlm.nih.gov/32500386
Editor’s Highlight: The Altered DNA Methylome of Chronic Doxorubicin Exposure in Sprague Dawley Rats
Publikováno v:
Toxicological Sciences. 159:470-479
Doxorubicin (DOX) is a widely used treatment for human cancers, but increases the risk of life-threatening congestive heart failure (CHF). DOX-induced mitochondrial damage is cumulative and persistent, similar to that observed clinically for risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577134c889ce3ace402860ef626a9dd6
https://doi.org/10.1093/toxsci/kfx150
https://doi.org/10.1093/toxsci/kfx150
Autor:
Paulo J. Oliveira, Cheryl Zehowski, Kendall B. Wallace, Andrew J Skildum, Kendra K. S. Nordgren, Cláudia M. Deus
Publikováno v:
Toxicology. 334:1-11
Doxorubicin (DOX) is currently used in cancer chemotherapy, however, its use often results in adverse effects highlighted by the development of cardiomyopathy and ultimately heart failure. Interestingly, DOX cardiotoxicity is decreased by resveratrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdc5b736139ef4e9e1394453780f309
https://doi.org/10.1016/j.tox.2015.05.001
https://doi.org/10.1016/j.tox.2015.05.001
Autor:
Teresa Cunha-Oliveira, Kendall B. Wallace, Paulo J. Oliveira, Ana Burgeiro, André F. Ferreira, Kendra K. S. Nordgren, Rui F. Simões, Filipa Carvalho
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Doxorubicin (DOX), a potent and broad-spectrum antineoplastic agent, causes an irreversible, cumulative and dose-dependent cardiomyopathy that ultimately leads to congestive heart failure. The mechanisms responsible for DOX cardiotoxicity remain poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd61e19c0065e8de3bc590e45597762
https://hdl.handle.net/10316/44845
https://hdl.handle.net/10316/44845
Publikováno v:
Toxicology and Applied Pharmacology. 274:107-116
Doxorubicin (DOX) is a widely prescribed treatment for a broad scope of cancers, but clinical utility is limited by the cumulative, dose-dependent cardiomyopathy that occurs with repeated administration. DOX-induced cardiotoxicity is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483d478ae68440f6ec1c1d01c04a6053
https://doi.org/10.1016/j.taap.2013.10.023
https://doi.org/10.1016/j.taap.2013.10.023
Autor:
Yi Peng, Vivien C. Yee, Ryan Abo, Richard M. Weinshilboum, Irene Moon, Eric D. Wieben, Gregory D. Jenkins, Bruce W. Eckloff, Brooke L. Fridley, Yuan Ji, Linda L. Pelleymounter, Xiaoshan Chai, Scott J. Hebbring, Kendra K. S. Nordgren, Yubo Chai, Jianping Zhang
Publikováno v:
Drug Metabolism and Disposition. 40:1984-1992
The "methionine cycle" plays a critical role in the regulation of concentrations of (S)-adenosylmethionine (AdoMet), the major biological methyl donor. We set out to study sequence variation in genes encoding the enzyme that synthesizes AdoMet in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea7112a2a4354bf61eecc013d2b1aa7
https://doi.org/10.1124/dmd.112.046953
https://doi.org/10.1124/dmd.112.046953
Autor:
Richard M. Weinshilboum, Irene Moon, Yi Peng, Eric D. Wieben, Kendra K. S. Nordgren, QiPing Feng, Vivien C. Yee, Linda L. Pelleymounter, Ryan Abo, Bruce W. Eckloff
Publikováno v:
Drug Metabolism and Disposition. 39:2135-2147
Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the major biological methyl donor. MAT1A and MAT2A encode two distinct MAT isoforms in mammals. MAT2A is expressed in nonhepatic tissues, whereas MAT1A is expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd5d9e38b7aa1961e0525ead02787ef
https://doi.org/10.1124/dmd.111.040857
https://doi.org/10.1124/dmd.111.040857
Publikováno v:
European journal of clinical investigation. 45
Background Epigenetic control of gene expression is mediated by cytosine methylation/demethylation and histone modifications including methylation, acetylation and glycosylation. The epigenetic programme is corrupted in cancer cells to maintain a pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69033c4eb94901f83048337f031b029
https://pubmed.ncbi.nlm.nih.gov/25524581
https://pubmed.ncbi.nlm.nih.gov/25524581
Autor:
Brooke L. Fridley, Gregory D. Jenkins, Richard M. Weinshilboum, Ann M. Moyer, Yuan Ji, Krishna R. Kalari, Linda L. Pelleymounter, Kendra K. S. Nordgren, Anthony Batzler, Yubo Chai
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 120(1)
Acetaminophen is the leading cause of acute hepatic failure in many developed nations. Acetaminophen hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinonimine (NAPQI). We performed a "discovery" genome-wide association study u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c2a4e4d1520c8d6bf72a75033a29ff
https://pubmed.ncbi.nlm.nih.gov/21177773
https://pubmed.ncbi.nlm.nih.gov/21177773