Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kendra J. Alfson"'
Autor:
Fatai S. Oladunni, Jun-Gyu Park, Paula A. Pino, Olga Gonzalez, Anwari Akhter, Anna Allué-Guardia, Angélica Olmo-Fontánez, Shalini Gautam, Andreu Garcia-Vilanova, Chengjin Ye, Kevin Chiem, Colwyn Headley, Varun Dwivedi, Laura M. Parodi, Kendra J. Alfson, Hilary M. Staples, Alyssa Schami, Juan I. Garcia, Alison Whigham, Roy Neal Platt, Michal Gazi, Jesse Martinez, Colin Chuba, Stephanie Earley, Oscar H. Rodriguez, Stephanie Davis Mdaki, Katrina N. Kavelish, Renee Escalona, Cory R. A. Hallam, Corbett Christie, Jean L. Patterson, Tim J. C. Anderson, Ricardo Carrion, Edward J. Dick, Shannan Hall-Ursone, Larry S. Schlesinger, Xavier Alvarez, Deepak Kaushal, Luis D. Giavedoni, Joanne Turner, Luis Martinez-Sobrido, Jordi B. Torrelles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality,
Externí odkaz:
https://doaj.org/article/36d6d32972464a4aafa1c9bc19844493
Autor:
Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M. Janus, Eric I. Felner, Dengning Xia, Yenny Goez-Gazi, Kendra J. Alfson, Abdul S. Yunus, Eric A. Toth, Gilad Ofek, Ricardo Carrion, Mark R. Prausnitz, Thomas R. Fuerst, Alexander K. Andrianov
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 1, p 16 (2022)
Ebolavirus (EBOV) infection in humans is a severe and often fatal disease, which demands effective interventional strategies for its prevention and treatment. The available vaccines, which are authorized under exceptional circumstances, use viral vec
Externí odkaz:
https://doaj.org/article/a885540978ff4542aea23a7fac2aa739
Autor:
Courtney L. Finch, Thomas H. King, Kendra J. Alfson, Katie A. Albanese, Julianne N. P. Smith, Paul Smock, Jocelyn Jakubik, Yenny Goez-Gazi, Michal Gazi, John W. Dutton, Elizabeth A. Clemmons, Marc E. Mattix, Ricardo Carrion, Thomas Rudge, Alex Ridenour, Sovann F. Woodin, Ruth Hunegnaw, Nancy J. Sullivan, Rong Xu
Publikováno v:
Vaccines, Vol 10, Iss 11, p 1935 (2022)
Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24–88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for a prophylactic vaccine, but no cand
Externí odkaz:
https://doaj.org/article/e79916c895fc4bc1a38bf77fcd628996
Autor:
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Ying-Liang Chou, Nancy A. Niemuth, Marc E. Mattix, Hilary Staples, Benjamin Klaffke, Gloria F. Rodriguez, Priscilla Escareno, Carmen Bartley, Anysha Ticer, Elizabeth A. Clemmons, John W. Dutton III, Anthony Griffiths, Gabe T. Meister, Daniel C. Sanford, Chris M. Cirimotich, Ricardo Carrion
Publikováno v:
Vaccines, Vol 10, Iss 10, p 1723 (2022)
The primary objective of this study was to characterize the disease course in cynomolgus macaques exposed to Sudan virus (SUDV), to determine if infection in this species is an appropriate model for the evaluation of filovirus countermeasures under t
Externí odkaz:
https://doaj.org/article/2cc1aa54e7954ee49dfdea798a0267ee
Autor:
Cheryl A. Triplett, Nancy A. Niemuth, Christopher Cirimotich, Gabriel Meister, Mimi Guebre-Xabier, Nita Patel, Mike Massare, Greg Glenn, Gale Smith, Kendra J. Alfson, Yenny Goez-Gazi, Ricardo Carrion
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1338 (2022)
Non-human primate (NHP) efficacy data for several Ebola virus (EBOV) vaccine candidates exist, but definitive correlates of protection (CoP) have not been demonstrated, although antibodies to the filovirus glycoprotein (GP) antigen and other immunolo
Externí odkaz:
https://doaj.org/article/9f5f0105e3644ef080388e11bc6aa289
Autor:
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Ying-Liang Chou, Nancy A. Niemuth, Marc E. Mattix, Hilary M. Staples, Benjamin Klaffke, Gloria F. Rodriguez, Carmen Bartley, Anysha Ticer, Elizabeth A. Clemmons, John W. Dutton, Anthony Griffiths, Gabe T. Meister, Daniel C. Sanford, Chris M. Cirimotich, Ricardo Carrion
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1314 (2022)
Marburg virus (MARV) is a filovirus that can infect humans and nonhuman primates (NHPs), causing severe disease and death. Of the filoviruses, Ebola virus (EBOV) has been the primary target for vaccine and therapeutic development. However, MARV has a
Externí odkaz:
https://doaj.org/article/21c882aa05dc43e9936872174f3053a7
Publikováno v:
Animals, Vol 11, Iss 7, p 2039 (2021)
Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highl
Externí odkaz:
https://doaj.org/article/849c1d1e310949688f909ad3b08db239
Autor:
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Hilary Staples, Marc Mattix, Anysha Ticer, Benjamin Klaffke, Kaylee Stanfield, Priscilla Escareno, Patrick Keiser, Anthony Griffiths, Ying-Liang Chou, Nancy Niemuth, Gabe T. Meister, Chris M. Cirimotich, Ricardo Carrion
Publikováno v:
Microorganisms, Vol 9, Iss 3, p 489 (2021)
Ebola virus (EBOV) is a negative-sense RNA virus that can infect humans and nonhuman primates with severe health consequences. Development of countermeasures requires a thorough understanding of the interaction between host and pathogen, and the cour
Externí odkaz:
https://doaj.org/article/ca56abe4ce0f4b8db6ddfb6339616cf3
Autor:
Kendra J. Alfson, Laura E. Avena, Jenny Delgado, Michael W. Beadles, Jean L. Patterson, Ricardo Carrion, Anthony Griffiths
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
ABSTRACT Marburg virus (MARV) causes disease with high case fatality rates, and there are no approved vaccines or therapies. Licensing of MARV countermeasures will likely require approval via the FDA’s Animal Efficacy Rule, which requires well-char
Externí odkaz:
https://doaj.org/article/088abe44dfaf4ff38fcf4dba86cab5a9
Autor:
Kendra J. Alfson, Laura E. Avena, Michael W. Beadles, Gabriella Worwa, Melanie Amen, Jean L. Patterson, Ricardo Carrion, Anthony Griffiths
Publikováno v:
Viruses, Vol 10, Iss 11, p 642 (2018)
The filoviruses Ebola virus (EBOV) and Sudan virus (SUDV) can cause severe diseases, and there are currently no licensed countermeasures available for use against them. Transmission occurs frequently via contact with bodily fluids from infected indiv
Externí odkaz:
https://doaj.org/article/0ca0812721654f0f97dd173dee47c9f6