Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kendra A. Hyland"'
Autor:
Branden S Moriarity, Eric P Rahrmann, Dominic A Beckmann, Caitlin B Conboy, Adrienne L Watson, Daniel F Carlson, Erik R Olson, Kendra A Hyland, Scott C Fahrenkrug, R Scott McIvor, David A Largaespada
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96114 (2014)
The advent of Transcription Activator-Like Effector Nucleases (TALENs), and similar technologies such as CRISPR, provide a straightforward and cost effective option for targeted gene knockout (KO). Yet, there is still a need for methods that allow fo
Externí odkaz:
https://doaj.org/article/a67c56a202d14176b28d0ed4ffb24785
Autor:
Kendra A. Hyland, R. Scott McIvor, Jason B. Bell, David W. Hunter, Erik R. Olson, Roland Gunther, Perry B. Hackett, Elena L. Aronovich, Myra Rusten
Publikováno v:
Human Gene Therapy. 28:541-550
The Sleeping Beauty transposon system has been extensively tested for integration of reporter and therapeutic genes in vitro and in vivo in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17f61ca01269aded0fc54f5a4897d65
https://doi.org/10.1089/hum.2017.003
https://doi.org/10.1089/hum.2017.003
Publikováno v:
Human Gene Therapy. 26:657-663
The Sleeping Beauty (SB) transposon system can insert sequences into mammalian chromosomes, supporting long-term expression of both reporter and therapeutic genes. Hematopoietic progenitor cells (HPCs) are an ideal therapeutic gene transfer target as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55aeb077162ca95b7e273464f34b079
https://doi.org/10.1089/hum.2015.058
https://doi.org/10.1089/hum.2015.058
Autor:
Elena L. Aronovich, Myra Rusten, Jason B. Bell, Bryan C. Hall, David W. Hunter, N. Matthew Ellinwood, R. Scott McIvor, Erik R. Olson, Perry B. Hackett, Kendra A. Hyland
Publikováno v:
Human gene therapy. 28(7)
The non-viral, integrating Sleeping Beauty (SB) transposon system is efficient in treating systemic monogenic disease in mice, including hemophilia A and B caused by deficiency of blood clotting factors and mucopolysaccharidosis types I and VII cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f921ce5b196844fd855506cec4e681
https://pubmed.ncbi.nlm.nih.gov/28719250
https://pubmed.ncbi.nlm.nih.gov/28719250
Autor:
Erik R. Olson, Perry B. Hackett, Bruce R. Blazar, R. Scott McIvor, Kendra A. Hyland, Karl J. Clark, Jakub Tolar, Elena L. Aronovich
Publikováno v:
The Journal of Gene Medicine. 13:462-469
Background The Sleeping Beauty (SB) transposon system can insert defined sequences into chromosomes to direct the extended expression of therapeutic genes. Our goal is to develop the SB system for nonviral complementation of Fanconi anemia (FA), a ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6133d6fc42a7d56f11d4c8c829bcf32f
https://doi.org/10.1002/jgm.1589
https://doi.org/10.1002/jgm.1589
Autor:
Robert Brennan, Stephen B. Olmsted, Eduardo Rojas, Ellen Murphy, Beinan Wang, P. Patrick Cleary, Kendra A. Hyland
Publikováno v:
FEMS Immunology & Medical Microbiology. 55:422-431
Streptococcus pyogenes is a major causative agent of tonsillitis or pharyngitis in children. Streptococcus pyogenes can persist in tonsils, and one-third of children treated with antibiotics continue to shed streptococci and have recurrent infections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce22e7d37cf8c638be102bdf891744d
https://doi.org/10.1111/j.1574-695x.2009.00540.x
https://doi.org/10.1111/j.1574-695x.2009.00540.x
Publikováno v:
Veterinary Immunology and Immunopathology. 109:1-11
Salmonella enterica serovar Choleraesuis is an enteric pathogen of swine, producing septicemia, enterocolitis, pneumonia, and hepatitis. The initial molecular events at the site of Salmonella infection are hypothesized to be critical in the initiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f297d93a0e036142dad6f70ff39d1c6b
https://doi.org/10.1016/j.vetimm.2005.06.016
https://doi.org/10.1016/j.vetimm.2005.06.016
Autor:
R. Scott McIvor, Elena L. Aronovich, Myra Rusten, Chester B. Whitley, Kendra A. Hyland, David W. Hunter, Perry B. Hackett, Erik R. Olson, Jason B. Bell, N. Matthew Ellinwood, Bryan C. Hall
Publikováno v:
Molecular Therapy. 24:S174
The non-viral integrating vector the Sleeping Beauty (SB) transposon system is efficient in treating systemic monogenic diseases in mice including mucopolysaccharidosis (MPS) types I and VII caused by α-iduronidase (IDUA) and β-glucuronidase (GUSB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b617866458e6ba1a6bbe28f875424c6
https://doi.org/10.1016/s1525-0016(16)33248-8
https://doi.org/10.1016/s1525-0016(16)33248-8
Autor:
Kendra A, Hyland, Erik R, Olson, Karl J, Clark, Elena L, Aronovich, Perry B, Hackett, Bruce R, Blazar, Jakub, Tolar, R, Scott McIvor
Publikováno v:
The journal of gene medicine. 13(9)
The Sleeping Beauty (SB) transposon system can insert defined sequences into chromosomes to direct the extended expression of therapeutic genes. Our goal is to develop the SB system for nonviral complementation of Fanconi anemia (FA), a rare autosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0258c5a97e49daf350058931828c2d0f
https://pubmed.ncbi.nlm.nih.gov/21766398
https://pubmed.ncbi.nlm.nih.gov/21766398
Autor:
P. Patrick Cleary, Kendra A. Hyland, Thamotharampillai Dileepan, Sarah Briscoe, Beinan Wang, Johnthomas Kang, Alexander Khoruts
Recurrent group AStreptococcus(GAS) tonsillitis and associated autoimmune diseases indicate that the immune response to this organism can be ineffective and pathological. TGF-β1 is recognized as an essential signal for generation of regulatory T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19baaefdeeb8894b694cc81760a19f1
https://europepmc.org/articles/PMC2851870/
https://europepmc.org/articles/PMC2851870/
