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pro vyhledávání: '"Kendall S. Frazier"'
Autor:
Kendall S. Frazier
Publikováno v:
Toxicologic Pathology. 50:408-414
Drug-induced kidney injury has historically been associated with renal tubule injury related to small molecule pharmaceuticals such as nonsteroidal anti-inflammatory drugs, antineoplastic agents, or antibiotics, but as a greater number of alternative
Autor:
Kendall S. Frazier
Publikováno v:
Toxicologic Pathology. 49:1377-1388
Drug responses are often unpredictable in juvenile animal toxicity studies; hence, optimizing dosages is challenging. Renal functional differences based on age of development will often result in vastly different toxicologic responses. Developmental
Autor:
Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Jindou Shi, Kajari Bera, Chi Zhang, Darold R. Spillman, Marina Marjanovic, Michael Fazio, Punit Seth, Kendall S. Frazier, Steve R. Hood, Stephen A. Boppart
Publikováno v:
Visualizing and Quantifying Drug Distribution in Tissue VI.
Autor:
Andrew W. Suttie, Leslie A. Obert, Mohamoud M. Abdi, Kendall S. Frazier, Tracy L. Gales, Wayne Fritz, Lucinda Weir, David Dwyer, Nicola Robertson
Publikováno v:
Toxicologic Pathology. 48:766-783
We describe and characterize unilateral renal aplasia in a cynomolgus monkey ( Macaca fascicularis) from a chronic toxicology study adding to the limited histopathology reports of congenital renal anomalies in macaques. In the current case, the affec
Autor:
Edita Aksamitiene, Kendall S. Frazier, Aneesh Alex, Chi Zhang, Steve R. Hood, Kajari Bera, Punit P. Seth, Marina Marjanovic, Jindou Shi, Michael Fazio, Prabuddha Mukherjee, Stephen A. Boppart, Darold R. Spillman
Publikováno v:
Nucleic acid therapeutics. 32(3)
Antisense oligonucleotides (ASOs), a novel paradigm in modern therapeutics, modulate cellular gene expression by binding to complementary messenger RNA (mRNA) sequences. While advances in ASO medicinal chemistry have greatly improved the efficiency o
Autor:
Félix Goulet, Nacera Mellal, Liangfu Chen, Mark S Watkins, Elaine Debien, David F. Adams, Roberta A. Thomas, Wei Shi, Kendall S. Frazier, Erding Hu, Luc Durette, Josée Laliberté
Publikováno v:
Toxicologic Pathology. 48:362-378
Daprodustat (GSK1278863) is a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor in development for treatment of anemia of chronic kidney disease. Daprodustat’s biological activity simulates components of the natural response to hypo
Publikováno v:
Toxicologic Pathology. 47:645-648
In histopathology, the presence of a tissue change that does not represent the tissue’s normal appearance can often lead to an incorrect diagnosis and interpretation. These changes are collectively known as “artifacts” resulting from postmortem
Publikováno v:
Toxicol Pathol
A host of novel renal biomarkers have been developed over the past few decades which have enhanced monitoring of renal disease and drug-induced kidney injury in both preclinical studies and in humans. Since chronic kidney disease (CKD) and acute kidn
Autor:
Kendall S Frazier, Elke Gasthuys, Michiel F. Schreuder, An Bael, Connie Chen, Ruud R.G. Bueters
Publikováno v:
Drug Metabolism and Disposition, 48, 5, pp. 353-367
Drug Metabolism and Disposition, 48, 353-367
DRUG METABOLISM AND DISPOSITION
Drug Metabolism and Disposition, 48, 353-367
DRUG METABOLISM AND DISPOSITION
Contains fulltext : 220821.pdf (Publisher’s version ) (Open Access) The kidneys play an important role in many processes, including urine formation, water conservation, acid-base equilibrium, and elimination of waste. The anatomic and functional de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84f8aec5667cc8b77b9fb08fce01e54
https://hdl.handle.net/2066/220821
https://hdl.handle.net/2066/220821
Autor:
Kendall S. Frazier, Leslie A. Obert
Publikováno v:
Toxicologic Pathology. 46:904-917
Prevalence of immune-mediated glomerulonephritis has increased in preclinical toxicity studies, with more frequent use of biotherapeutic agents (especially antigenic humanized molecules) and antisense oligonucleotide (ASO) therapies. Immune complex d