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Autor:
Emily Rimes, Coran M. H. Watanabe, Brendan Foley, Kendall Pryor, Flor Martinez, Lauren A Washburn, Rachel P Lee
Publikováno v:
Biochemistry. 58(52)
The biosynthesis of the azinomycins involves the conversion of glutamic acid to an aziridino[1,2-a]pyrrolidine moiety, which together with the epoxide moiety imparts anticancer activity to these agents. The mechanism of azabicycle formation is comple