Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kendall M. Mohler"'
Autor:
Yan Chen, Daniel Sommermeyer, Stanley R. Riddell, Steven M Shamah, Alexander I. Salter, Tyler Hill, Kendall M. Mohler
Publikováno v:
Leukemia
Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune responses specific for peptides from the murine scFv ant
Autor:
Davinder Gill, William Brady, Stephane Olland, Neil M. Wolfman, Marion T. Kasaian, Cheryl Nickerson-Nutter, Richard Zollner, Mary Collins, David Wensel, Kyri Dunussi-Joannopoulos, Yulia Vugmeyster, Deborah Herber, Lioudmila Tchistiakova, Kendall M. Mohler, Barbara Sibley, Alan Wahl, Nilufer P. Seth, Peter Robert Baum
Publikováno v:
Rheumatology (Oxford, England)
Objectives. To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in vivo B-cell depletion activity with the mutated 2LM20-4 P331S [no in vitro com
Autor:
Emil Y. Chi, Shawn J. Skerrett, Jacques J. Peschon, Christopher B. Wilson, Thomas R. Martin, Kendall M. Mohler
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 276:L715-L727
To determine the roles of the type 1 tumor necrosis factor (TNF) receptor (TNFR1) in lung inflammation and antibacterial defense, we exposed transgenic mice lacking TNFR1 [TNFR1(−/−)] and wild-type control mice to aerosolized lipopolysaccharide o
Autor:
Mark S. Rutherford, Mathew B. Baker, Robert B. Levy, Bruce R. Blazar, Kendall M. Mohler, Michael J. Bennett, Eckhard R. Podack, Mesha Austin, Lawrence B. Schook, Patricia A. Taylor, Vinay Kumar
Publikováno v:
International Immunology. 10:785-790
Mouse NK cells may use both cytokine, e.g. IFN-gamma, tumor necrosis factor (TNF)-alpha and IL-12, and cytotoxic, e.g. perforin and Fas-FasL, pathways to reject incompatible bone marrow cell (BMC) grafts. To begin a dissection of these two major path
TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation
Autor:
Jacques J. Peschon, Dauphine S. Torrance, Kim L. Stocking, Moira B. Glaccum, Carol Otten, Cynthia R. Willis, Keith Charrier, Philip J. Morrissey, Carol B. Ware, Kendall M. Mohler
Publikováno v:
The Journal of Immunology. 160:943-952
The pleiotropic activities of the potent proinflammatory cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types. The majority of biologic responses classically
Autor:
Beverly J. Castner, Fiona H. Durie, Mary Gerhart, Yoshifumi Itoh, David H. Lynch, Roy A. Black, Jennifer L. Slack, Robert E. Miller, Yasunori Okada, Kendall M. Mohler, Hideaki Nagase, Carol Otten-Evans, Richard S. Johnson
Publikováno v:
Biochemical and Biophysical Research Communications. 225:400-405
Tumor necrosis factor-alpha is released from cells by a proteolytic cleavage. Previous work suggested that a specific, non-matrix metalloproteinase carries out this cleavage, but matrix metalloproteinases have also been implicated. In this paper, we
Autor:
Carol Otten-Evans, Kendall M. Mohler, Carl F. Ware, Paul D. Crowe, Barbara N. Walter, Roy A. Black
Publikováno v:
The Journal of Experimental Medicine
TNF is synthesized as a 26-kD membrane-anchored precursor and is proteolytically processed at the cell surface to yield the mature secreted 17-kD polypeptide. The 80-kD tumor necrosis factor (TNF) receptor (TNFR80) is also proteolytically cleaved at
Autor:
Richard J. Armitage, Steven F. Ziegler, William C. Fanslow, Kenneth A. Schooley, Brian M. Macduff, Charles Rauch, Melanie K. Spriggs, Carl J. March, Kendall M. Mohler, Ky N. Clifford
Publikováno v:
Blood. 81:2998-3005
Biotinylated interleukin-4 (IL-4) was used to examine IL-4 receptor (IL- 4R) expression on a range of human B-cell lines by flow cytometry. Using high concentrations of biotinylated IL-4, we have identified a novel low-affinity IL-4 receptor expresse
Autor:
Gloria Jean Macewan, Chuansheng Niu, J.S. Skotnicki, Dauphine Barone, A. Zask, C. Crago, Ayral-Kaloustian Semiranis, Amy Sung, Roy A. Black, R. Cowling, Kendall M. Mohler, Terri Cummons, Gulnaz Khafizova, Jeremy I. Levin, Derek C. Cole, E. Delos Santos, E.J. Salaski, Katherine Cheung, G. Jin, Yuhua Zhang, Weixin Xu, X. Du, James M. Chen, Jun Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(16)
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1' group, was explored. In particular, compound 5j has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1
Autor:
Loran M. Killar, S. Skala, James M. Chen, X. Du, G. Jin, Roy A. Black, A. Zask, Michele A. Sharr, Gu Yansong, R. Cowling, C.J March, J.S. Skotnicki, J. D. Albright, Amy Sung, Dauphine Barone, John F. DiJoseph, C. E. Roth, Kendall M. Mohler, Jeremy I. Levin, M. Hogan
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(8)
Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus MMPs and TACE could be controlled by appropriate substitution on the scaffolds and by varia