Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kenan Direk"'
Autor:
Burcu Ozaltin, Robert Chapman, Muhammad Qummer Ul Arfeen, Natalie Fitzpatick, Harry Hemingway, Kenan Direk, Joseph Jacob
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Our study examined whether prevalent and incident comorbidities are increased in idiopathic pulmonary fibrosis (IPF) patients when compared to matched chronic obstructive pulmonary disease (COPD) patients and control subjects with
Externí odkaz:
https://doaj.org/article/8f63f50e07194a849eb318b44b9ecc32
Autor:
Constantin-Cristian Topriceanu, Eesha Dev, Mahmood Ahmad, Rebecca Hughes, Hunain Shiwani, Matthew Webber, Kenan Direk, Andrew Wong, Martin Ugander, James C. Moon, Alun D. Hughes, Jane Maddock, Todd T. Schlegel, Gabriella Captur
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background DNA methylation (DNAm) age acceleration (AgeAccel) and cardiac age by 12-lead advanced electrocardiography (A-ECG) are promising biomarkers of biological and cardiac aging, respectively. We aimed to explore the relationships betwe
Externí odkaz:
https://doaj.org/article/e91430dc36f344b3b9b0d182e9b29e69
Autor:
Matt Webber, Aneesh Varma, George Joy, MD, Jonathan Bennett, Fiona Chan, Rebecca Hughes, Hunain Shiwani, Rhodri Davies, MD, PhD, Constantin-Cristian Topriceanu, Emma Martin, Andrew Wong, Alicja Rapala, Kenan Direk, Charlotte Manisty, MD, PhD, Nishi Chaturvedi, Thomas Treibel, MD, PhD, Michele Orini, Tim Evain, Iain Pierce, PhD, Peter Kellman, James Moon, MD, Alun Hughes, MD, PhD, Anish Bhuva, Gabriella Captur, MD, PhD
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss , Pp 100238- (2024)
Externí odkaz:
https://doaj.org/article/f93f629209d64b98ae89d2f493048614
Autor:
Valerie Kuan, Helen C. Fraser, Melanie Hingorani, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Dorothea Nitsch, Rohini Mathur, Constantinos A. Parisinos, R. Thomas Lumbers, Reecha Sofat, Ian C. K. Wong, Juan P. Casas, Janet M. Thornton, Harry Hemingway, Linda Partridge, Aroon D. Hingorani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Reducing the burden of late-life morbidity requires an understanding of the mechanisms of ageing-related diseases (ARDs), defined as diseases that accumulate with increasing age. This has been hampered by the lack of formal criteria to ident
Externí odkaz:
https://doaj.org/article/a4cfa63aeff54b99ac644b906f56e8bb
Autor:
Gesche M. Huebner, Nicole E. Watson, Kenan Direk, Eoghan McKenna, Ellen Webborn, Frances Hollick, Simon Elam, Tadj Oreszczyn
Publikováno v:
Buildings & Cities, Vol 2, Iss 1 (2021)
To contain the spread of Covid-19, governments across the world imposed partial or complete lockdowns. National energy demand decreased in periods of lockdowns; however, as people spent more time at home, residential energy use likely increased. This
Externí odkaz:
https://doaj.org/article/4af75ec13a104e9b922a37ab59392138
Autor:
Suvi Härmälä, Alastair O’Brien, Constantinos A. Parisinos, Kenan Direk, Laura Shallcross, Andrew Hayward
Publikováno v:
Diagnostic and Prognostic Research, Vol 3, Iss 1, Pp 1-11 (2019)
Abstract Background Driven by alcohol consumption and obesity, the prevalence of non-viral liver disease in the UK is increasing. Due to its silent and slow nature, the progression of liver disease is currently unpredictable and challenging to monito
Externí odkaz:
https://doaj.org/article/96286bcc0e5e4bdba4f0cecf606f0c68
Autor:
Spiros Denaxas, Kenan Direk, Arturo Gonzalez-Izquierdo, Maria Pikoula, Aylin Cakiroglu, Jason Moore, Harry Hemingway, Liam Smeeth
Publikováno v:
BioData Mining, Vol 10, Iss 1, Pp 1-19 (2017)
Abstract Background The ability of external investigators to reproduce published scientific findings is critical for the evaluation and validation of biomedical research by the wider community. However, a substantial proportion of health research usi
Externí odkaz:
https://doaj.org/article/8bdbf81417224e5cbb3a0471e671747c
Autor:
Valerie Kuan, MBBS, Spiros Denaxas, PhD, Arturo Gonzalez-Izquierdo, PhD, Kenan Direk, PhD, Osman Bhatti, FRCGP, Shanaz Husain, MBBS, Shailen Sutaria, FFPH, Melanie Hingorani, FRCOphth, Dorothea Nitsch, ProfMD, Constantinos A Parisinos, MRCP, R Thomas Lumbers, PhD, Rohini Mathur, PhD, Reecha Sofat, PhD, Juan P Casas, ProfPhD, Ian C K Wong, ProfPhD, Harry Hemingway, ProfFFPH FRCP, Aroon D Hingorani, ProfPhD
Publikováno v:
The Lancet: Digital Health, Vol 1, Iss 2, Pp e63-e77 (2019)
Summary: Background: To effectively prevent, detect, and treat health conditions that affect people during their lifecourse, health-care professionals and researchers need to know which sections of the population are susceptible to which health condi
Externí odkaz:
https://doaj.org/article/e5b06d849205495190a8a2bda5d4673a
Autor:
Riyaz S. Patel, Natalie K Fitzpatrick, Aroon D. Hingorani, R. Tom Lumbers, Richard Dobson, Spiros Denaxas, Kenan Direk, Cathie Sudlow, Harry Hemingway, Laura Pasea, Laurence J. Howe, Amitava Banerjee, Arturo Gonzalez-Izquierdo, Ghazaleh Fatemifar, Valerie Kuan, Anoop D. Shah
Publikováno v:
Denaxas, S, Gonzalez-Izquierdo, A, Direk, K, Fitzpatrick, N K, Fatemifar, G, Banerjee, A, Dobson, R J B, Howe, L J, Kuan, V, Lumbers, R T, Pasea, L, Patel, R S, Shah, A D, Hingorani, A D, Hemingway, H & Sudlow, C 2019, ' UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER ', Journal of the American Medical Informatics Association, vol. 26, no. 12, pp. 1545–1559 . https://doi.org/10.1093/jamia/ocz105
Journal of the American Medical Informatics Association
Journal of the American Medical Informatics Association : JAMIA
Journal of the American Medical Informatics Association
Journal of the American Medical Informatics Association : JAMIA
ObjectiveElectronic health records (EHRs) are a rich source of information on human diseases, but the information is variably structured, fragmented, curated using different coding systems, and collected for purposes other than medical research. We d
Autor:
Kenan Direk, Harry Hemingway
Publikováno v:
Eur J Heart Fail
Primary prevention strategies for heart failure (HF) have had limited success, possibly due to a wide range of underlying risk factors (RFs). Systematic evaluations of the prognostic burden and preventive potential across this wide range of risk fact