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Differential Expression of Smad7 Transcripts Identifies the CD4+CD45RChigh Regulatory T Cells That Mediate Type V Collagen-Induced Tolerance to Lung Allografts

Autor: M. Azizul Haque, Kena Woods, Kazuhiro Yasufuku, Kathleen M. Heidler, Yan Zheng, Janice S. Blum, Oscar W. Cummings, Gerald N. Smith, Teruaki Mizobuchi, Takehiko Fujisawa, David S. Wilkes

Publikováno v: The Journal of Immunology. 171:1140-1147

Regulatory T cells (Tregs) induced by oral tolerance may suppress immunity by production of TGF-β that could also enhance Treg activity. However, all cells that are phenotypically Tregs in rats (CD4+CD45RChigh-RChigh) may not have regulatory functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eb0d2004d3913d3815bea64e3fa00b
https://doi.org/10.4049/jimmunol.171.3.1140

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Evidence for Immune Responses to a Self-Antigen in Lung Transplantation: Role of Type V Collagen-Specific T Cells in the Pathogenesis of Lung Allograft Rejection

Autor: Teruaki Mizobuchi, M. Azizul Haque, Yan Zheng, Kazuhiro Yasufuku, Randy R. Brutkiewicz, Kathleen M. Heidler, Kena Woods, Janice S. Blum, David S. Wilkes, Takehiko Fujisawa, Oscar W. Cummings, Gerald N. Smith

Publikováno v: The Journal of Immunology. 169:1542-1549

We have reported that lung allograft rejection involves an immune response to a native protein in the lung, type V collagen (col(V)), and that col(V)-induced oral tolerance prevented acute and chronic rejection. In support of these findings col(V) fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f87a799031609d5d959030bd3ba079
https://doi.org/10.4049/jimmunol.169.3.1542

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Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance1

Autor: Kathleen M. Heidler, Oscar W. Cummings, Gerald N. Smith, Kena Woods, Takehiko Fujisawa, David S. Wilkes, Kazuhiro Yasufuku

Publikováno v: Transplantation. 73:500-505

Background We have reported that feeding type V collagen (col(V)) to lung allograft recipients induces immune tolerance that prevents acute lung allograft rejection. Repeated acute rejection is a risk factor for or associated with chronic rejection,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41d89a831a1d7ae594660e3cf1dd2efa
https://doi.org/10.1097/00007890-200202270-00002

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Instillation of Allogeneic Lung Antigen-Presenting Cells Deficient in Expression of Major Histocompatibility Complex Class I or II Antigens Have Differential Effects on Local Cellular and Humoral Immunity and on Pathology in Recipient Murine Lungs

Autor: Brian H. Foresman, R A Sidner, Kathleen M. Heidler, Kena Woods, Carol T. Schnizlein-Bick, Kemba Baker, Oscar W. Cummings, David S. Wilkes

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 23:499-505

Recognition of allogeneic major histocompatibility complex (MHC) molecules expressed on donor lung antigen-presenting cells (APCs) by host T lymphocytes is believed to stimulate lung allograft rejection. However, the specific roles of donor MHC molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052abdd7e7c8a2f6e3d0852a7b659677
https://doi.org/10.1165/ajrcmb.23.4.4172

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Nucleotide Sequence and Characterization of Human Papillomavirus Type 83, a Novel Genital Papillomavirus

Autor: Kena Woods, Darron R. Brown, Tracy L. McClowry, Kenneth H. Fife

Publikováno v: Virology. 260(1):165-172

Studies of human papillomaviruses (HPV) are hampered by the lack of a conventional culture system, because HPV completes its life cycle only in fully differentiated human tissue. To overcome this obstacle, the athymic mouse xenograft system has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368986bfc04ff8b93c126efa2813bbb8

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