Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Ken-ichiro Kamei"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Dry eye syndrome (DES) is a complex ocular condition characterized by an unstable tear film and inadequate tear production, leading to tissue damage. Despite its common occurrence, there is currently no comprehensive in vitro model that accu
Externí odkaz:
https://doaj.org/article/993d755fc2b6446f9e91a2966e43e61e
Autor:
Jiandong Yang, Yoshikazu Hirai, Kei Iida, Shinji Ito, Marika Trumm, Shiho Terada, Risako Sakai, Toshiyuki Tsuchiya, Osamu Tabata, Ken-ichiro Kamei
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
A model system for studying non-alcoholic fatty liver disease is created by co-culturing human gut and liver cell lines in a closed circulation loop using microfluidics.
Externí odkaz:
https://doaj.org/article/554a28702a274231bfba91a90f5384a0
Publikováno v:
Acta Materia Medica, Vol 1, Iss 4, Pp 411-426 (2022)
Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that i
Externí odkaz:
https://doaj.org/article/1011838ca1a444a38e774994c39a82d7
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Despite explosive growth in the development of nano-drug delivery systems (NDDS) targeting tumors in the last few decades, clinical translation rates are low owing to the lack of efficient models for evaluating and predicting responses. Micr
Externí odkaz:
https://doaj.org/article/f562983ddeb44addb04a9a6a4e94ab71
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Hepatocyte-like cells derived from human pluripotent stem cells (hPSC-HLCs) offer an alternative to primary hepatocytes commonly used for drug screenings and toxicological tests. However, these cells do not have hepatic functions comparable
Externí odkaz:
https://doaj.org/article/f2a6435a978d448ebc80d9ee22e82219
Autor:
Xiaoling Liu, Er Zu, Xinyu Chang, Xiaowei Ma, Ziqi Wang, Xintong Song, Xiangru Li, Qing Yu, Ken-ichiro Kamei, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima, Dan Ohtan Wang
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 12 (2021)
Skeletal muscle regeneration requires extracellular matrix (ECM) remodeling, including an acute and transient breakdown of collagen that produces gelatin. Although the physiological function of this process is unclear, it has inspired the application
Externí odkaz:
https://doaj.org/article/9734941b32c847bd8d85296f34299117
Autor:
Koki Yoshimoto, Nicolas Minier, Jiandong Yang, Satoshi Imamura, Kaylene Stocking, Janmesh Patel, Shiho Terada, Yoshikazu Hirai, Ken-ichiro Kamei
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Hepatic development requires multiple sequential physicochemical environmental changes in an embryo, and human pluripotent stem cells (hPSCs) allow for the elucidation of this embryonic developmental process. However, the current in vitro methods for
Externí odkaz:
https://doaj.org/article/2e1477a339094a309d06c9ab38a48210
Publikováno v:
Micromachines, Vol 12, Iss 5, p 550 (2021)
Microfluidic microphysiological systems (MPSs) or “organs-on-a-chip” are a promising alternative to animal models for drug screening and toxicology tests. However, most microfluidic devices employ polydimethylsiloxane (PDMS) as the structural mat
Externí odkaz:
https://doaj.org/article/6c4fed2504034066adeb936328ccf8f6
Publikováno v:
Physical Review Research, Vol 2, Iss 1, p 013360 (2020)
Enzymatic ligation is essential for the synthesis of long DNA. However, a number of ligated products exponentially decay as DNA synthesis proceeds randomly. The control of ligation randomness is important to suppress exponential decay and achieve eff
Externí odkaz:
https://doaj.org/article/97acc44b8e8946038d7171f6230cf06b
Publikováno v:
Proceedings, Vol 1, Iss 4, p 302 (2017)
To study drug response on human heart cells and predict drug induced cardiotoxicity, a microfluidic cell culture device with an integrated microelectrode array (MEA) is a promising approach. Here we integrate flexible MEA into microengineered and mic
Externí odkaz:
https://doaj.org/article/b42780b2382843aeb2f83a7d6bd19f67