Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ken-ichi Saeki"'
Autor:
Yuki Kitamura1, Ken-ichi Saeki1,2 ksaeki@kinjo-u.ac.jp
Publikováno v:
Drug Discoveries & Therapeutics. Aug2020, Vol. 14 Issue 4, p204-208. 5p.
Autor:
Sakae Arimoto-Kobayashi, Yuki Kitamura, Azuki Ozawa, Ken-ichi Saeki, Yuri Saeki, Mayuko Sakanashi, Yuiho Hara, Ayano Nakamura
Publikováno v:
Biochemical and Biophysical Research Communications. 555:154-159
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress-induced neuronal death has been identified as one of the major causes of nigrost
Publikováno v:
Mutation research. 821
We have previously reported that quinoline increased the mutation frequency of the cII gene in the liver of lambda/lacZ transgenic mice (Muta™Mouse), and G:C to C:G transversions were the molecular signature of quinoline-induced mutations. 4-Methyl
Publikováno v:
Journal of Health Science. 53:320-324
Fluorinated derivatives of 4,10-diazachrysene (DAC) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of rat liver S9 to investigate the metabolic activation pathway of DAC. We have previously reported that metabolism
Autor:
Kenji Takeshita, Ken-ichi Saeki, Makoto Hayashi, Minoru Kadoi, Toshio Sofuni, Takayoshi Suzuki
Publikováno v:
Journal of Health Science. 53:325-328
Quinoline and four monofluorinated derivatives of quinoline (FQ's) were tested for their clastogenicity in a Chinese hamster lung (CHL) cell line using chromosomal aberration (CA) and micronucleus (MN) tests. Quinoline and all the fluoroquinolines, 3
Publikováno v:
Journal of Health Science. 53:470-474
Induction of micronucleated liver cells (MN-liver cells) was examined with the hepatocarcinogenic quinoline and its fluorinated derivatives, 3-fluoroquinoline (3-FQ) and 5-fluoroquinoline (5-FQ), using non-hepatectomized rats and mice. Male F344 rats
Publikováno v:
Journal of Health Science. 52:821-824
To investigate the inhibitory effect of aza-polycyclic aromatic compounds on cytochrome P450 (CYP) 2C9 activity and analyze the fluorine-substitution effects on the CYP2C9 inhibition, benzo[h]quinoline (BhQ) and its fluorinated derivatives, 3-F-, 5-F
Publikováno v:
Journal of Health Science. 52:623-627
Nine halogenated anilines, consisting of di- and tri-substituted fluoro-, chloro-, and bromoanilines, were subjected to analysis of their cytochrome P450 (CYP) 2E1/2A6-selective inhibitory effects on metabolic activation of dimetylnitrosamine (DMN) i
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 586:87-95
Nitrogen-containing analogs of chrysene, 1,10-diazachrysene (1,10-DAC) and 4,10-DAC, were tested for mutagenicity in Salmonella typhimurium TA100 in the presence of rat liver S9 and human liver microsomes to investigate the effect of nitrogen-substit
Autor:
Takaharu Mizutani, Ken-ichi Saeki, Takayoshi Suzuki, Taka-aki Kato, Katsuya Yamada, Arihiro Kohara, Makoto Hayashi
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 586:1-17
We have previously reported the in vivo mutagenicity of aza-polycyclic aromatic hydrocarbons (azaPAHs), such as quinoline, benzo[f]quinoline, benzo[h]quinoline, 1,7-phenanthroline and 10-azabenzo[a]pyrene. The 1,10-diazachrysene (1,10-DAC) and 4,10-D