Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Ken-ichi SAITO"'
Autor:
Yutaka Inoue, Takashi Morita, Mari Onozuka, Ken-ichi Saito, Kazumi Sano, Kazuhiko Hanada, Masami Kondo, Yoichi Nakamura, Tohru Kishino, Hiroshi Nakagawa, Yoji Ikegami
Publikováno v:
Cells, Vol 8, Iss 7, p 763 (2019)
The ATP-binding cassette transporter ABCG2 is expressed in various organs, such as the small intestine, liver, and kidney, and influences the pharmacokinetics of drugs that are its substrates. ABCG2 is also expressed by cancer cells and mediates resi
Externí odkaz:
https://doaj.org/article/3ecbd52459a14c97af857cb116d25df0
Autor:
Daiki Sakai, Kazutoshi Watanabe, Mika Nabeno, Hiroshi Tanaka, Shinji Tanaka, Shinji Sunada, Jun-ichi Eguchi, Keiko Takiguchi-Hayashi, Ken-Ichi Saito, Shin-ichi Kusaka, Kazuki Nakayama, Kenji Fukunaga, Toshiyuki Kohara, Tomoko Bessho, Takashi Horikawa, Akiko Mori
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55de72f14f1f283259756ae9c42b53f
https://pubmed.ncbi.nlm.nih.gov/28712706
https://pubmed.ncbi.nlm.nih.gov/28712706
Autor:
Adachi Takashi, Narihiko Yoshii, Kazutoshi Watanabe, Fumiaki Uehara, Mika Nabeno, Takashi Horikawa, Kenji Fukunaga, Ken-Ichi Saito, Shinji Sunada, Satoshi Yokoshima, Shinji Tanaka, Satoshi Yuki, Shouichi Asano, Aya Shouda, Hiroshi Tanaka, Shinsuke Hiki, Keiichi Aritomo, Masatake Fujimura, Keiji Yamagami, Yoshihiro Usui, Jun-ichi Eguchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(16)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15af65e99a9d19a8f0c2d46937023c5e
https://pubmed.ncbi.nlm.nih.gov/28712708
https://pubmed.ncbi.nlm.nih.gov/28712708
Autor:
Jun-ichi Eguchi, Shinsuke Hiki, Masatake Fujimura, Satoshi Yuki, Shinji Sunada, Tokushi Hanano, Masahiro Okuyama, Fumiaki Uehara, Toshiyuki Kohara, Hiroshi Tanaka, Keiichi Aritomo, Susumu Tsuchiya, Ken-Ichi Saito, Kenji Fukunaga, Kazutoshi Watanabe, Shoichi Asano, Koichi Yamakoshi, Hiroshi Baba, Shinji Tanaka, Takashi Horikawa, Yoshihiro Usui, Aya Shoda, Akiko Mori, Keiji Yamagami
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6933-6937
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a885218d2050bd32f637b9c4aaa1822
https://doi.org/10.1016/j.bmcl.2013.09.020
https://doi.org/10.1016/j.bmcl.2013.09.020
Publikováno v:
Journal of Neural Transmission. 115:1037-1046
MKC-231, a putative cholinergic activity, is reported to improve learning and memory impaired in AF64A-treated animals. MKC-231 enhances high-affinity choline uptake (HACU) known as the rate-limiting step of acetylcholine (ACh) synthesis. We investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b60b1a331db9c3258ee20b54edceaa
https://doi.org/10.1007/s00702-008-0049-0
https://doi.org/10.1007/s00702-008-0049-0
Publikováno v:
Journal of Neural Transmission. 115:1027-1035
The effect of MKC-231 on acetylcholine (ACh) synthesis and release was studied in the hippocampus of normal and AF64A-treated rats. AF64A (3 nmol/brain, i.c.v.) produced significant reduction of high-affinity choline uptake (HACU) and high K+-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfc8edcb26ade5455ecc9828bdefed8
https://doi.org/10.1007/s00702-008-0048-1
https://doi.org/10.1007/s00702-008-0048-1
Autor:
Osamu Tagusari, Kiyoharu Nakano, Ken-ichi Saito, Kentaro Honda, Yoshitsugu Nakamura, Nobuyuki Homma, Shizu Oyamada, Ryozo Miyamoto
Publikováno v:
Japanese Journal of Cardiovascular Surgery. 37:213-216
弁膜症患者の術前における口腔内病変の罹患率は不明である．今回，弁膜症手術患者の口腔内病変の罹患率について調査，検討した．また菌血症をおこしうる病変があった場合，抜歯を
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bc520d3464c2d07f40f2aa0b041053
https://doi.org/10.4326/jjcvs.37.213
https://doi.org/10.4326/jjcvs.37.213
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:1599-1603
Hange-shashin-to (HST) has been used as an herbal formula to treat inflammatory ulcerative gut diseases complicated with psychoneurosis in Japanese traditional Kampo medicine. The aim of the present study is to clarify anti-colitic effect of HST usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bee2eb95c20c20ae1e907650648704e
https://doi.org/10.1248/bpb.27.1599
https://doi.org/10.1248/bpb.27.1599
Publikováno v:
Pharmacology Biochemistry and Behavior. 68:677-683
We have previously reported that MCI-225, a selective noradrenaline (NA) reuptake inhibitor with serotonin (5-HT) 3 receptor antagonism, shows antidepressant-like properties in experiments using rodents. In this study, we investigated the effect of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe38480c907da88717e7effece4ccff
https://doi.org/10.1016/s0091-3057(01)00485-3
https://doi.org/10.1016/s0091-3057(01)00485-3
Autor:
Hannosuke Wakushima, Toshiaki Makino, Hajime Fujii, Ken-ichi Saito, Yasuyuki Furuta, Yoshihiro Kano, Nakagawa Takashi
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:1206-1209
Perilla frutescens Britton (perilla, Labiatae) is a medicinal herb prescribed in Saiboku-to [Japanese letters: see text], which is a Kampo formula effective for allergic diseases such as bronchial asthma. The present study was conducted to evaluate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ef66d32ad3d2023b468c17842fb038
https://doi.org/10.1248/bpb.24.1206
https://doi.org/10.1248/bpb.24.1206