Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ken-ichi Ohtani"'
Autor:
Hiroyuki Shimizu, Noriyuki Sato, Yohnosuke Shimomura, Takahumi Tsuchiya, Hiroki Takahashi, Masatomo Mori, Yutaka Uehara, Ken-Ichi Ohtani
Publikováno v:
Nutritional neuroscience. 1(1)
The activation of sympathetic activity which is related to hypothalamic corticotropin-releasing hormone (CRH) release may modulate ob gene expression in vivo. In the present studies, we determined changes in circulating leptin concentrations by modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f01622386e3416216ff557c65018ba0
https://pubmed.ncbi.nlm.nih.gov/27405913
https://pubmed.ncbi.nlm.nih.gov/27405913
Autor:
Hiroyuki Shimizu, Mikiko Kishi, Takafumi Tsuchiya, Shuichi Okada, Shinsuke Oh-I, Yasuyo Ariyama, Ken-Ichi Ohtani, Masatomo Mori, Kenju Shimomura
Publikováno v:
Islets. 3:150-154
Obese people show marked hyerinsulinemia, but the exact mechanism has not been clarified. Hyperleptinemia is one possible candidate, although there is an obvious difference in the effect of leptin on insulin secretion between isolated pancreatic isle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99be244fb08b40694caefec86615d98f
https://doi.org/10.4161/isl.3.4.15733
https://doi.org/10.4161/isl.3.4.15733
Autor:
Adrian D. Bonev, Michelle Jamnongjit, Yuepeng Wang, Richard H. Karas, Ken-ichi Ohtani, Howard K. Surks, Simon K. Michael, Mark Aronovitz, Mark T. Nelson, Yan Zhu, Michael K. Wilkerson, Michael E. Mendelsohn, Robert M. Blanton, Wendy Baur
Publikováno v:
Proceedings of the National Academy of Sciences. 105:6702-6707
Hypertension, a major cardiovascular risk factor and cause of mortality worldwide, is thought to arise from primary renal abnormalities. However, the etiology of most cases of hypertension remains unexplained. Vascular tone, an important determinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064f0bf5736cccd3ceece6fe8c4fbca9
https://doi.org/10.1073/pnas.0802128105
https://doi.org/10.1073/pnas.0802128105
Publikováno v:
Current Topics in Medicinal Chemistry. 6:733-745
This review article describes the development of in vivo active antagonists for the glycine binding site of the NMethyl- D-Aspartate (NMDA) receptor. There were several difficulties in identifying a class of antagonists with in vivo efficacy and only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccd151500b0834ca54e99bb83bbc49c
https://doi.org/10.2174/156802606776894500
https://doi.org/10.2174/156802606776894500
Publikováno v:
Neurochemistry International. 42:375-384
The purpose of this study was to investigate the effect of (3S)-7-chloro-3-[2-((1R)-1-carboxyethoxy)-4-aminomethylphenyl]aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[c,d]indole-2-carboxylic acid hydrochloride (SM-31900), an antagonist with high selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f47c938dba010133da849308fd8fc27
https://doi.org/10.1016/s0197-0186(02)00137-7
https://doi.org/10.1016/s0197-0186(02)00137-7
Autor:
Hiroki Takahashi, Atsushi Kuwabara, Hiroyuki Shimizu, Hideaki Tomura, Takahumi Tsuchiya, Masatomo Mori, Ken-Ichi Ohtani, Takao Kimura, Fumikazu Okajima, Koichi Sato
Publikováno v:
Endocrine Journal. 47:261-269
Sphingosine is involved in the regulation of cellular processes as a second messenger in various kinds of cells. Since the possible involvement of sphingosine has not been investigated in pancreatic beta-cells, we determined the expression of putativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb357822d46536fd3ef79007233a31c1
https://doi.org/10.1507/endocrj.47.261
https://doi.org/10.1507/endocrj.47.261
Autor:
Hirokazu Yasuda, Hideki Sakamoto, Yukihiro Ohno, Chika Tamamura, Akiko Kawabe, Hiroyasu Tanaka, Mitsutaka Nakamura, Ken-ichi Ohtani, Yoshimi Maruoka
Publikováno v:
General Pharmacology: The Vascular System. 29:645-649
1. The effects of N-methyl-D-aspartate (NMDA) receptor glycine-binding site antagonists 7-chlorokynurenate (7-Clkyn) and (±)-3-amino-1-hydroxy-2-pyrrolidone (HA-966) on spinal reflexes in an isolated spinal cord that was maintained in Mg2+-free medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b055c72cf17abe3d6572df7c1f362c
https://doi.org/10.1016/s0306-3623(96)00514-9
https://doi.org/10.1016/s0306-3623(96)00514-9
Autor:
Y Shimomura, R Hayashi, T Futawatari, Ken-Ichi Ohtani, Hiroyuki Shimizu, Noriyuki Sato, Masatomo Mori
Publikováno v:
International Journal of Obesity. 21:536-541
The obese (ob) gene encodes leptin which inhibits appetite and stimulates thermogenesis. Serum leptin concentrations are determined by total body fat mass, but the influence of visceral fat accumulation and other metabolic factors have been clinicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46808b5af799cf2f9b3d2a28bdb54987
https://doi.org/10.1038/sj.ijo.0800437
https://doi.org/10.1038/sj.ijo.0800437
Publikováno v:
Diabetes Research and Clinical Practice. 33:15-19
Prophylactic insulin treatment prevents the development of hyperglycemia in animal models of insulin-dependent diabetes mellitus. Acarbose is a new antidiabetic drug which improves hyperglycemia by inhibiting alpha-glucosidase. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d597eb3de657a8d8c75b4f07bc643358
https://doi.org/10.1016/0168-8227(96)01254-5
https://doi.org/10.1016/0168-8227(96)01254-5
Publikováno v:
Neuroscience Letters. 204:81-84
We determined the changes in neuropeptide Y (NPY) mRNA expression of the arcuate nucleus (ARC) in sham-operated (SHAM) and bilaterally ovariectomized (OVX) rats with estradiol (E2) supplement. Ovariectomy increases body weight gain for 3 weeks, accom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f4ce77583d02925c4b1f8c1f871f57
https://doi.org/10.1016/0304-3940(96)12322-3
https://doi.org/10.1016/0304-3940(96)12322-3