Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ken-ichi Noma"'
Autor:
Chen Wang, Hideki Tanizawa, Connor Hill, Aaron Havas, Qiang Zhang, Liping Liao, Xue Hao, Xue Lei, Lu Wang, Hao Nie, Yuan Qi, Bin Tian, Alessandro Gardini, Andrew V. Kossenkov, Aaron Goldman, Shelley L. Berger, Ken-ichi Noma, Peter D. Adams, Rugang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high
Externí odkaz:
https://doaj.org/article/510df8c88f934aa994ca58141deaa581
Autor:
Kyoung-Dong Kim, Hideki Tanizawa, Alessandra De Leo, Olga Vladimirova, Andrew Kossenkov, Fang Lu, Louise C. Showe, Ken-ichi Noma, Paul M. Lieberman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Epstein-Barr virus (EBV) episomes tether to the host chromosome via EBNA1. Here, using circular chromosome conformation capture (4C), Kim et al. identify attachment sites and show that EBV episomes preferentially associate with transcriptionally sile
Externí odkaz:
https://doaj.org/article/bff55f2ca18e4d65ad7aa6a1d5db6db0
Autor:
Osamu Iwasaki, Hideki Tanizawa, Kyoung-Dong Kim, Andrew Kossenkov, Timothy Nacarelli, Sanki Tashiro, Sonali Majumdar, Louise C. Showe, Rugang Zhang, Ken-ichi Noma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Cell senescence involves stable arrest of cell proliferation and changes in gene expression and 3D genome reorganization. Here, the authors show that human condensin II complex participates in reorganization of the chromatin compartments, primarily t
Externí odkaz:
https://doaj.org/article/d6bfd9f78d8e46fe944d870a5010386b
Autor:
Mariana C Gadaleta, Mukund M Das, Hideki Tanizawa, Ya-Ting Chang, Ken-ichi Noma, Toru M Nakamura, Eishi Noguchi
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005943 (2016)
Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments pre
Externí odkaz:
https://doaj.org/article/c6127aa80e8249ceb911268fa59fb26b
Autor:
Takeshi Sakuno, Sanki Tashiro, Hideki Tanizawa, Osamu Iwasaki, Da-Qiao Ding, Tokuko Haraguchi, Ken-ichi Noma, Yasushi Hiraoka
Publikováno v:
Nucleic Acids Research. 50:3799-3816
During meiotic prophase, cohesin-dependent axial structures are formed in the synaptonemal complex (SC). However, the functional correlation between these structures and cohesion remains elusive. Here, we examined the formation of cohesin-dependent a
SummaryAneuploidy is caused by chromosomal missegregation and is frequently observed in cancers and hematological diseases. Pericentromeric heterochromatin formation is essential for proper chromosome segregation; however, it is unclear how heterochr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85113174a7278bed21c0dfe1feb1e78f
https://doi.org/10.1101/2022.09.15.508097
https://doi.org/10.1101/2022.09.15.508097
Autor:
Ken-ichi Noma, Kyoung-Dong Kim, Alessandra De Leo, Paul M. Lieberman, Louise C. Showe, Olga Vladimirova, Hideki Tanizawa, Fang Lu, Andrew V. Kossenkov
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Epstein-Barr virus (EBV) genomes persist in latently infected cells as extrachromosomal episomes that attach to host chromosomes through the tethering functions of EBNA1, a viral encoded sequence-specific DNA binding protein. Here we employ circular
Autor:
Hideki Tanizawa, Rugang Zhang, Osamu Iwasaki, Andrew V. Kossenkov, Sanki Tashiro, Ken-ichi Noma, Louise C. Showe, Kyoung-Dong Kim, Sonali Majumdar, Timothy Nacarelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D
Autor:
Shuai Wu, Katherine M. Aird, Joseph A. Zundell, David W. Speicher, Takeshi Fukumoto, David C. Schultz, Ken-ichi Noma, Zachary T. Schug, Osamu Iwasaki, Lena Lau, Rugang Zhang, Timothy Nacarelli, Nail Fatkhutdinov, Hsin Yao Tang, Joseph A. Baur, Andrew V. Kossenkov, Gregory David
Publikováno v:
Nature Cell Biology. 21:397-407
Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). NAD
Autor:
F. Brad Johnson, Osamu Iwasaki, Andrew V. Kossenkov, Linh Le, Gretchen M. Alicea, Hideki Tanizawa, Ting-Lin B. Yang, Nail Fatkhutdinov, Benjamin G. Bitler, Ken-ichi Noma, Katherine M. Aird, Rugang Zhang
Publikováno v:
The Journal of Cell Biology
In senescence, specific genes encoding secreted factors are excluded from senescence-associated heterochromatin foci, but the mechanisms underlying this senescence-associated secretory phenotype (SASP) are unclear. Aird et al. show that the chromatin