Výsledky vyhledávání - "Ken-ichi Kurihara"

A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest

Autor: Hiroshi Sakagami, Ryosuke Saijo, Masami Kawase, Eiji Tamai, Ken-ichi Kurihara, Jun Maki, Hiroshi Sekiya

Publikováno v: CHEMICAL & PHARMACEUTICAL BULLETIN. 65:365-372

In this report, we describe a new method for the synthesis of densely functionalized 2(1H)-pyrazinones. Treatment of mesoionic 1,3-oxazolium-5-olates with carbanions derived from activated methylene isocyanides (p-toluenesulfonylmethyl isocyanide (To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d45ec84a742f03fca010202f12c2f088
https://doi.org/10.1248/cpb.c16-00830

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A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest

Autor: Ryosuke, Saijo, Hiroshi, Sekiya, Eiji, Tamai, Ken-Ichi, Kurihara, Jun, Maki, Hiroshi, Sakagami, Masami, Kawase

Publikováno v: Chemicalpharmaceutical bulletin. 65(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::060b05f0166185efd191f116e544505d
https://pubmed.ncbi.nlm.nih.gov/28381677

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Novel ring transformation of mesoionic oxazoles into 2(1H)-pyrazinones by the reaction with TosMIC

Autor: Ken-ichi Kurihara, Hidemitsu Uno, Ryosuke Saijo, Kazuki Akira, Masami Kawase

Publikováno v: Tetrahedron Letters. 54:4418-4421

Treatment of mesoionic 1,3-oxazolium-5-olates with TosMIC in the presence of a base causes a novel ring transformation affording 2(1H)-pyrazinones in moderate yields. The origin of C-2 carbonyl oxygen in the product was elucidated to be molecular oxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::073ab8e5ac68265538ef04419bc8b721
https://doi.org/10.1016/j.tetlet.2013.06.018

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In vitro and in vivo characterization of novel nonsteroidal progesterone receptor antagonists derived from the fungal metabolite PF1092C

Autor: Yuji Tabata, Rie Shinei, Yasushi Kurata, Ken ichi Kurihara, Tsuneo Okonogi, Yumiko Iizuka, Naomi Takei Masuda, Shigeru Hoshiko

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 82:217-223

We studied the pharmacological effects of novel nonsteroidal progesterone receptor antagonists CP8661 and CP8754, which were synthesized from the fungal metabolite PF1092C. CP8661 possess a tetrahydrobenzindolone skeleton and CP8754 possess a tetrahy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d840e4a067e6c66a2fd783f5647e9c0
https://doi.org/10.1016/s0960-0760(02)00157-7

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Cladinose Analogues of Sixteen-membered Macrolide Antibiotics.IV. Improved Therapeutic Effects of 4-O-Acyl-L-cladinose Analogues of Sixteen-membered Macrolide Antibiotics

Autor: Osamu Hara, Hisashi Suzuki, Kikuchi Nobue, Shigeharu Inouye, Seiji Shibahara, Minako Araake, Shoji Omoto, Ken ichi Kurihara, Tsuneo Okonogi, Keiichi Ajito

Publikováno v: The Journal of Antibiotics. 50:150-161

Six derivatives of sixteen-membered macrolides possessing 4-O-acyl-alpha-L-cladinose as a neutral sugar were synthesized via 3"-methylthiomethyl ether intermediates in reasonable yield. Introduction of a methyl group on the 3"-hydroxyl group of midec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db512c59fc9ba9489d3ce61df1e5ff1
https://doi.org/10.7164/antibiotics.50.150

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ChemInform Abstract: Novel Ring Transformation of Mesoionic Oxazoles into 2(1H)-Pyrazinones by the Reaction with TosMIC

Autor: Masami Kawase, Hidemitsu Uno, Ryosuke Saijo, Kazuki Akira, Ken-ichi Kurihara

Publikováno v: ChemInform. 44

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b4941c46ddd3e7e7283a8f73bf84b6f
https://doi.org/10.1002/chin.201347166

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