Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ken-ichi Kazetani"'
Autor:
Osamu Sano, Ken‐ichi Kazetani, Ryutaro Adachi, Osamu Kurasawa, Tomohiro Kawamoto, Hidehisa Iwata
Publikováno v:
FEBS Open Bio, Vol 7, Iss 4, Pp 495-503 (2017)
Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate‐limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis‐
Externí odkaz:
https://doaj.org/article/81c20fbc2dc8451390aee1661eb2137b
Autor:
Akito Ono, Osamu Sano, Ken-Ichi Kazetani, Takamichi Muraki, Keisuke Imamura, Hiroyuki Sumi, Junji Matsui, Hidehisa Iwata
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181243 (2017)
Elucidating the bioactive compound modes of action is crucial for increasing success rates in drug development. For anticancer drugs, defining effective drug combinations that overcome resistance improves therapeutic efficacy. Herein, by using a biol
Externí odkaz:
https://doaj.org/article/50af3f8caf6146c78670a32051e30924
Autor:
Hidehisa Iwata, Ryutaro Adachi, Osamu Kurasawa, Tomohiro Kawamoto, Osamu Sano, Ken-ichi Kazetani
Publikováno v:
FEBS Open Bio
Mechanistic understanding is crucial to anti-cancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate-limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis-dep
Publikováno v:
FEBS Letters. 590:1576-1585
Lysosomal protein degradation via autophagy strictly regulates cellular protein homoeostasis. Herein we performed high-content screening to identify compounds that inhibit autophagy pathways. We obtained 11 hit compounds and performed cluster analysi
Autor:
Imamura Keisuke, Akito Ono, Takamichi Muraki, Hidehisa Iwata, Junji Matsui, Hiroyuki Sumi, Ken-ichi Kazetani, Osamu Sano
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181243 (2017)
PLoS ONE
PLoS ONE
Elucidating the bioactive compound modes of action is crucial for increasing success rates in drug development. For anticancer drugs, defining effective drug combinations that overcome resistance improves therapeutic efficacy. Herein, by using a biol
Publikováno v:
Biochemical and Biophysical Research Communications. 388:323-327
FliI ATPase forms a homo-hexamer to fully exert its ATPase activity, facilitating bacterial flagellar protein export. However, it remains unknown how FliI hexamerization is linked to protein export. Here, we analyzed the capability of ring formation
Publikováno v:
BMC Biochemistry
Background In drug discovery research, cell-based phenotypic screening is an essential method for obtaining potential drug candidates. Revealing the mechanism of action is a key step on the path to drug discovery. However, elucidating the target mole
Autor:
Keiichi Namba, Ken-ichi Kazetani, Tohru Minamino, Yukio Furukawa, May Kihara, Hirofumi Suzuki, Aiko Tahara
Publikováno v:
Journal of Molecular Biology. 360:510-519
Salmonella FliI is the flagellar ATPase which converts the energy of ATP hydrolysis into the export of flagellar proteins. It forms a ring-shaped oligomer in the presence of ATP, its analogs, or phospholipids. The extreme N-terminal region of FliI ha
Publikováno v:
Seibutsu Butsuri. 47:S159
Publikováno v:
Seibutsu Butsuri. 46:S361