Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Ken-ichi Hirano"'
Autor:
Yoshihiko Ikeda, Mikio Shiba, Hiroyuki Yamamoto, Tomonori Itoh, Takahiro Okumura, Yusuke Nakano, Hideyuki Miyauchi, Tomomi Ide, Sohsuke Yamada, Hiroyuki Hao, Seiya Kato, Ken‐ichi Hirano, the Japan TGCV study group
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 1275-1278 (2024)
Externí odkaz:
https://doaj.org/article/6ada686c355a4d41b9e6152c4d9515fd
Autor:
Abd Aziz Ibrahim, Taku Fujimura, Tomoko Uno, Tomoya Terada, Ken-ichi Hirano, Hiroyuki Hosokawa, Akio Ohta, Toshio Miyata, Kiyoshi Ando, Takashi Yahata
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIncreased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have been found to correlate with poor clinical outcomes in patients with cancer. Although abundant data support the involvement of PAI-1 in cancer progression, whether
Externí odkaz:
https://doaj.org/article/d02edfa23ac84b4a99017fbbb5525d16
Autor:
Tatsuro Aikawa, Eiryu Sai, Ayako Kudo, Yuko O Kawaguchi, Kazuhisa Takamura, Makoto Hiki, Takayuki Yokoyama, Tetsuro Miyazaki, Shinichiro Fujimoto, Kazunori Shimada, Ken-ichi Hirano, Hiroyuki Daida, Tohru Minamino
Publikováno v:
Endocrine Connections, Vol 1, Iss 1, Pp 1-5 (2023)
Triglyceride deposit cardiomyovasculopathy (TGCV) is an intractable disease characterized by massive triglyceride (TG) accumulation in the myocardium and coronary arteries caused by genetic or acquired dysfunction of adipose TG lipase (ATGL). A phase
Externí odkaz:
https://doaj.org/article/12eed4f026874eb086d93173ba521a3c
Autor:
Hirona Kugo, Yuki Sugiura, Rena Fujishima, Shintou Jo, Hirotaka Mishima, Erina Sugamoto, Hiroki Tanaka, Satoshi Yamaguchi, Yoshihiko Ikeda, Ken-Ichi Hirano, Tatsuya Moriyama, Nobuhiro Zaima
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114299- (2023)
Medical therapeutic options to prevent rupture of abdominal aortic aneurysm (AAA), a critical event, must be developed. Moreover, further understanding of the process of AAA development and rupture is crucial. Previous studies have revealed that aort
Externí odkaz:
https://doaj.org/article/61aac6346069457b8589b44e0c223ef1
Autor:
Yasuhiro Hara, Yoshihiko Ikeda, Hayato Kimura, Shinsaku Shimamoto, Mao Ishikawa, Kunihisa Kobayashi, Hironori Nagasaka, Hisashi Shimoyama, Ken-ichi Hirano
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 34, Iss , Pp 100960- (2023)
Primary triglyceride deposit cardiomyovasculopathy (P-TGCV), caused by a rare genetic mutation in PNPLA2 encoding adipose triglyceride lipase (ATGL), exhibits severe cardiomyocyte steatosis and heart failure. Here, we report the case of a 51-year-old
Externí odkaz:
https://doaj.org/article/7531a1ac2f99491d95ab7e4d8e40aa22
Autor:
Ken-ichi Hirano, Hiroyuki Hosokawa, Takashi Yahata, Kiyoshi Ando, Masayuki Tanaka, Jin Imai, Masaki Yazawa, Masato Ohtsuka, Naoko Negishi, Sonoko Habu, Takehito Sato, Katsuto Hozumi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T-cell development in the thymus is dependent on Notch signaling induced by the interaction of Notch1, present on immigrant cells, with a Notch ligand, delta-like (Dll) 4, on the thymic epithelial cells. Phylogenetic analysis characterizing the prope
Externí odkaz:
https://doaj.org/article/6e7a20644a1948fc86277519767bc960
Autor:
Ken-ichi Hirano, Hiroyuki Hosokawa, Maria Koizumi, Yusuke Endo, Takashi Yahata, Kiyoshi Ando, Katsuto Hozumi
Publikováno v:
eLife, Vol 10 (2021)
Notch signaling primarily determines T-cell fate. However, the molecular mechanisms underlying the maintenance of T-lineage potential in pre-thymic progenitors remain unclear. Here, we established two murine Ebf1-deficient pro-B cell lines, with and
Externí odkaz:
https://doaj.org/article/0ef8605041b74b7abf09a191f6d51579
Autor:
Ming Li, Ken-ichi Hirano, Yoshihiko Ikeda, Masahiro Higashi, Chikako Hashimoto, Bo Zhang, Junji Kozawa, Koichiro Sugimura, Hideyuki Miyauchi, Akira Suzuki, Yasuhiro Hara, Atsuko Takagi, Yasuyuki Ikeda, Kazuhiro Kobayashi, Yoshiaki Futsukaichi, Nobuhiro Zaima, Satoshi Yamaguchi, Rojeet Shrestha, Hiroshi Nakamura, Katsuhiro Kawaguchi, Eiryu Sai, Shu-Ping Hui, Yusuke Nakano, Akinori Sawamura, Tohru Inaba, Yasuhiko Sakata, Yoko Yasui, Yasuyuki Nagasawa, Shintaro Kinugawa, Kazunori Shimada, Sohsuke Yamada, Hiroyuki Hao, Daisaku Nakatani, Tomomi Ide, Tetsuya Amano, Hiroaki Naito, Hironori Nagasaka, Kunihisa Kobayashi, on behalf of the Japan TGCV study group
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-9 (2019)
Abstract Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases long chain fatty acid (LCFA) as a major energy so
Externí odkaz:
https://doaj.org/article/b62f55ce80454dd6a43a16d72cd67b1d
Autor:
Takashi Yahata, Abd Aziz Ibrahim, Ken-ichi Hirano, Yukari Muguruma, Kazuhito Naka, Katsuto Hozumi, Douglas E. Vaughan, Toshio Miyata, Kiyoshi Ando
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Therapeutic strategies that target leukemic stem cells (LSCs) provide potential advantages in the treatment of chronic myeloid leukemia (CML). Here, we show that selective blockade of plasminogen activator inhibitor-1 (PAI-1) enhances the susceptibil
Externí odkaz:
https://doaj.org/article/33be840ab0fa4143ad05bd208fc116c2
Autor:
Ken-ichi Hirano, Akiko Suganami, Yutaka Tamura, Hideo Yagita, Sonoko Habu, Motoo Kitagawa, Takehito Sato, Katsuto Hozumi
Publikováno v:
eLife, Vol 9 (2020)
Delta-like (Dll) 1 and Dll4 differently function as Notch ligands in a context-dependent manner. As these ligands share structural properties, the molecular basis for their functional difference is poorly understood. Here, we investigated the superio
Externí odkaz:
https://doaj.org/article/f11b723230544f3da5dc4682c7db396b