Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ken-ichi Hamagami"'
Autor:
Masako Sasaki, Ikuo Miyahisa, Sachiko Itono, Hiroaki Yashiro, Hideyuki Hiyoshi, Kazue Tsuchimori, Ken‐ichi Hamagami, Yusuke Moritoh, Masanori Watanabe, Kimio Tohyama, Minoru Sasaki, Jun‐ichi Sakamoto, Tomohiro Kawamoto
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 5, Pp n/a-n/a (2019)
Abstract Enteropeptidase, localized into the duodenum brush border, is a key enzyme catalyzing the conversion of pancreatic trypsinogen proenzyme to active trypsin, thereby regulating protein digestion and energy homeostasis. We report the discovery
Externí odkaz:
https://doaj.org/article/6a80d3a9b6c84d77bac6dd6c17560898
Autor:
Ken-ichi Hamagami, Yusuke Sakurai, Norihito Shintani, Naoko Higuchi, Kazuya Ikeda, Hitoshi Hashimoto, Akinobu Suzuki, Hiroshi Kiyama, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 4, Pp 451-458 (2009)
Abstract.: Development of human chronic pancreatitis is associated with intrapancreatic accumulation of pituitary adenylate cyclase–activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gas
Externí odkaz:
https://doaj.org/article/2b18a706089741fc9e8ad2b2eb59ce64
Autor:
Shuhei Tomimoto, Tatsuya Ojika, Norihito Shintani, Hitoshi Hashimoto, Ken-ichi Hamagami, Kazuya Ikeda, Masanori Nakata, Toshihiko Yada, Yusuke Sakurai, Takeshi Shimada, Yoshiko Morita, Chie Ishida, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 1, Pp 41-48 (2008)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide implicated in several metabolic functions, including insulin secretion and sympathoadrenal activation. To clarify the roles of PACAP in maintenance of whole-body glucose and
Externí odkaz:
https://doaj.org/article/3f4ce9701bc4438abd0e8dc41757167d
Autor:
Yukihiko Sugimoto, Akemichi Baba, Soken Tsuchiya, Kazuki Nagayasu, Atsushi Kasai, Mai Koumoto, Norihito Shintani, Ryota Hashimoto, Shota Tanaka, Tadayasu Ohkubo, Shintaro Higashi, Atsushi Ichikawa, Takuya Yoshida, Hitoshi Hashimoto, Kazuya Ikeda, Ken Ichi Hamagami, Shuhei Tomimoto, Takanobu Nakazawa, Yukio Ago, Atsuko Hayata-Takano, Naoki Inoue, Kazuhiko Katagi, Yusuke Onaka
Publikováno v:
Biochemical and Biophysical Research Communications. 461:612-617
We examined the pancreatic function of p13 encoded by 1110001J03Rik, whose expression is decreased in pancreatic islets in high-fat-fed diabetic mice, by generating transgenic mice overexpressing p13 (p13-Tg) in pancreatic β-cells. p13-Tg mice showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb74c4e3685025e3754f7aa0633817f
https://doi.org/10.1016/j.bbrc.2015.04.074
https://doi.org/10.1016/j.bbrc.2015.04.074
Autor:
Shuhei Tomimoto, Hitoshi Hashimoto, Kazuya Ikeda, Takanobu Nakazawa, Kazuki Nagayasu, Atsuko Hayata-Takano, Atsushi Kasai, Soken Tsuchiya, Yukihiko Sugimoto, Ken Ichi Hamagami, Norihito Shintani, Atsushi Ichikawa, Akemichi Baba
Publikováno v:
Biochemistry and Biophysics Reports
In diabetes mellitus, pituitary adenylate cyclase-activating polypeptide (PACAP) has insulinotropic and glucose-lowering properties. We previously demonstrated that transgenic mice overexpressing PACAP in pancreatic β-cells (PACAP-Tg) show attenuate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de28fb0e7a854bb69932f71c2b7ffc96
http://europepmc.org/articles/PMC5668656
http://europepmc.org/articles/PMC5668656
Autor:
Atsuko Hayata-Takano, Hitoshi Hashimoto, Yusuke Sakurai, Akihiro Arimori, Norihito Shintani, Hiroaki Inoue, Akemichi Baba, Ken-ichi Hamagami
Publikováno v:
Journal of Molecular Neuroscience. 48:647-653
Inadequate compensatory insulin secretion is observed during the development of type 2 diabetes and deteriorates over time in a manner that is difficult to reverse. Here, we found that plasma glucose levels in genetically diabetic KKA(y) mice fed a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224e6fb0cfe22c348f44d5691e42f9ba
https://doi.org/10.1007/s12031-012-9758-9
https://doi.org/10.1007/s12031-012-9758-9
Autor:
Naoko Higuchi, Hitoshi Hashimoto, Kazuya Ikeda, Atsuko Hayata, Norihito Shintani, Akihiro Arimori, Hiroaki Inoue, Akemichi Baba, Ken-ichi Hamagami, Yusuke Sakurai
Publikováno v:
Journal of Molecular Neuroscience. 43:8-15
In our previous study, we reported that cerulein-induced acute pancreatitis is aggravated in pancreatic β-cell-specific pituitary adenylate cyclase-activating polypeptide (PACAP) transgenic mice, showing that an increase in pancreatic PACAP is a ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbcc14ea527eb9bfafc72043991806e
https://doi.org/10.1007/s12031-010-9396-z
https://doi.org/10.1007/s12031-010-9396-z
Autor:
Takeshi Shimada, Yoshiko Morita, Norihito Shintani, Tatsuya Ojika, Masanori Nakata, Shuhei Tomimoto, Hitoshi Hashimoto, Kazuya Ikeda, Ken-ichi Hamagami, Yusuke Sakurai, Chie Ishida, Toshihiko Yada, Akemichi Baba
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 1, Pp 41-48 (2008)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide implicated in several metabolic functions, including insulin secretion and sympathoadrenal activation. To clarify the roles of PACAP in maintenance of whole-body glucose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56431e3bec3c153b08094a7e832e5bf9
https://doi.org/10.1254/jphs.fp0072173
https://doi.org/10.1254/jphs.fp0072173
Autor:
Miki Okada-Iwabu, Mamiko Yamaguchi, Masato Iwabu, Tomomi Kimura-Someya, Akiko Tanaka, Toshimasa Yamauchi, Takashi Kadowaki, Teruki Honma, Tetsuo Nagano, Koichi Matsuda, Kumpei Tokuyama, Mikako Shirouzu, Hiroaki Tanabe, Ken-ichi Hamagami, Shigeyuki Yokoyama, Hitomi Ogata, Kohjiro Ueki
Publikováno v:
Nature. 503(7477)
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2, and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively. Levels of adiponectin in plasma are reduced in obesity, which causes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3d86bb46082a6325c1b63ba56ecd04
https://pubmed.ncbi.nlm.nih.gov/24247222
https://pubmed.ncbi.nlm.nih.gov/24247222
Autor:
Norihito Shintani, Hiroshi Kiyama, Hitoshi Hashimoto, Kazuya Ikeda, Ken-ichi Hamagami, Yusuke Sakurai, Naoko Higuchi, Akemichi Baba, Akinobu Suzuki
Publikováno v:
Journal of Pharmacological Sciences, Vol 110, Iss 4, Pp 451-458 (2009)
Development of human chronic pancreatitis is associated with intrapancreatic accumulation of pituitary adenylate cyclase–activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gastrointest L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a21d97ceca5041d867f3e6cd9598be
https://pubmed.ncbi.nlm.nih.gov/19672038
https://pubmed.ncbi.nlm.nih.gov/19672038