Výsledky vyhledávání - "Ken-ichi Arimura"

Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure

Autor: Kensuke Egashira, Akira Takeshita, Ken-ichi Arimura, Hiroaki Shimokawa, Ryo Nakamura, Hiroyuki Tsutsui, Tomomi Ide, Youji Machida

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 281:H2619-H2625

Recent evidence suggests that increased inactivation of endothelium-derived nitric oxide (NO) by oxygen free radical (OFR) formation is involved in the pathogenesis of endothelial dysfunction in heart failure (HF). However, it is unclear whether incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a27c4c934382a8986007469bd00ca67
https://doi.org/10.1152/ajpheart.2001.281.6.h2619

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Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure

Autor: Akira Takeshita, Kensuke Egashira, Hiroaki Shimokawa, Hiroyuki Tsutsui, Tomomi Ide, Ken-ichi Arimura, Ryo Nakamura

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 280:H68-H75

Recent evidence suggests the possibility that enhanced inactivation of endothelium-derived nitric oxide (NO) by oxygen free radical (OFR) may cause endothelial dysfunction in heart failure (HF). To test this hypothesis, we examined the effect of anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc905928f573f2595a38e3e3fd280ba1
https://doi.org/10.1152/ajpheart.2001.280.1.h68

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Coronary Vascular K+ATP Channels Contribute to the Maintenance of Myocardial Perfusion in Dogs With Pacing-Induced Heart Failure

Autor: Mitsutaka Yamamoto, Hideo Tada, Kensuke Egashira, Hiroaki Shimokawa, Akira Takeshita, Ken-ichi Arimura

Publikováno v: Japanese Circulation Journal. 64:701-707

The functional role of coronary vascular ATP-sensitive potassium (K+ATP) channels in the regulation of coronary blood flow (CBF) has not been determined in chronic heart failure (CHF). To test the hypothesis that K+ATP channels contribute to myocardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7381ae64deceb4c15edbad5eda68cf9
https://doi.org/10.1253/jcj.64.701

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Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes

Autor: Ken ichi Arimura, Shintaro Kinugawa, Hiroyuki Tsutsui, Tomomi Ide, Kensuke Egashira, Akira Takeshita, Ryo Nakamura

Publikováno v: Cardiovascular Research. 43:157-164

Objective: The acute administration of growth hormone (GH) or insulin-like growth factor-1 (IGF-1) improves cardiac performance, possibly contributing to the beneficial effects of GH therapy on heart failure (HF). GH can induce the production of IGF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29e59e21956b95fbee7f895f4aea897
https://doi.org/10.1016/s0008-6363(99)00058-9

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Simultaneous assessment of wall motion and coronary flow velocity in the left anterior descending coronary artery during dipyridamole stress echocardiography

Autor: Ken-ichi Arimura, Yuichi Nohtomi, Shoichi Kondo, Akira Yamada, Kenji Miyata, Shuichi Okamatsu, Kouichi Kuwata, Tohru Yamawaki, Masaaki Takeuchi, Kazushige Nagasawa

Publikováno v: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 16(5)

This study was designed to assess the feasibility and clinical meaning of simultaneous assessment of wall motion and coronary flow velocity (CFV) reserve in the left anterior descending coronary artery (LAD) by transthoracic approach for detecting LA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ae4c51e8f3f300f0cdb0dcc4fd4404
https://pubmed.ncbi.nlm.nih.gov/12724655

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Role of Ca2+ availability to myofilaments and their sensitivity to Ca2+ in myocyte contractile dysfunction in heart failure

Autor: Shinji Satoh, Shintaro Kinugawa, Hiroyuki Tsutsui, Tomomi Ide, Masaru Takahashi, Kensuke Egashira, Akira Takeshita, Ken ichi Arimura, Keiko Igarashi-Saito

Publikováno v: Cardiovascular research. 44(2)

Objective: Contractile function is depressed at the isolated myocyte level in heart failure (HF), which could result from the decreased availability of intracellular calcium ([Ca2+]i) to the myofibrils and/or the depressed sensitivity of myofilaments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd049f2280a91198c8fc19b18475be8
https://pubmed.ncbi.nlm.nih.gov/10690316

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Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium

Autor: Ken ichi Arimura, Kensuke Egashira, Nobutaka Hattori, Akira Takeshita, Koji Uchida, Hideo Utsumi, Hiroyuki Tsutsui, Tomomi Ide, Shintaro Kinugawa, Dongchon Kang

Publikováno v: Circulation research. 85(4)

Abstract —Oxidative stress in the myocardium may play an important role in the pathogenesis of congestive heart failure (HF). However, the cellular sources and mechanisms for the enhanced generation of reactive oxygen species (ROS) in the failing m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70ef97e649ff434b7edb675eb5c6d73
https://pubmed.ncbi.nlm.nih.gov/10455064

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