Zobrazeno 1 - 10
of 593
pro vyhledávání: '"Ken-ichi Fujita"'
Autor:
Asuka Mizutani, Masato Kobayashi, Kodai Nishi, Ken-ichi Fujita, Kotaro Takahashi, Yuka Muranaka, Kakeru Sato, Masanori Kitamura, Chie Suzuki, Ryuichi Nishii, Naoto Shikano, Yasuhiro Magata, Yasushi Ishida, Munetaka Kunishima, Kazuki Fukuchi, Keiichi Kawai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: As drug-metabolizing enzyme activities are affected by a variety of factors, such as drug-drug interactions, a method to evaluate drug-metabolizing enzyme activities in real time is needed. In this study, we developed a novel SPECT imagin
Externí odkaz:
https://doaj.org/article/79b4f5f8af464c61a0f3b515bbb3d561
Autor:
Ken-ichi Fujita, Misa Ito, Midori Irie, Kotaro Harada, Naoko Fujiwara, Yuya Ikeda, Hanae Yoshioka, Tomohiro Yamazaki, Masaki Kojima, Bunzo Mikami, Akila Mayeda, Seiji Masuda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract mRNA export is an essential pathway for the regulation of gene expression. In humans, closely related RNA helicases, UAP56 and URH49, shape selective mRNA export pathways through the formation of distinct complexes, known as apo-TREX and apo
Externí odkaz:
https://doaj.org/article/066ce3ac6a0a40738dbd62c192aafabf
Autor:
Ken‐ichi Fujita, Natsumi Matsumoto, Remi Murase, Kosuke Takeshima, Hiroo Ishida, Yutaro Kubota
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1741-1747 (2023)
Abstract Regorafenib improves the survival of patients with metastatic colorectal cancer (mCRC); however, it is also characterized by detrimental dermal side effects that may require treatment cessation or modified dosing. In our previous prospective
Externí odkaz:
https://doaj.org/article/d0852674197946e3aea5afc90a221a27
Publikováno v:
Applied Microbiology, Vol 3, Iss 3, Pp 666-674 (2023)
Pterostilbene has been shown to exhibit antifungal activities. However, the detailed action mechanism is unknown. Here, we analyzed the antifungal mechanism of pterostilbene against Saccharomyces cerevisiae. The minimum growth inhibitory and fungicid
Externí odkaz:
https://doaj.org/article/512058ba35a24827ad6139a180d34519
Autor:
Yuta Nio, Hiroo Ishida, Natsumi Matsumoto, Sojiro Kusumoto, Yutaro Kubota, Takuya Tsunoda, Yasutsuna Sasaki, Ken-ichi Fujita
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Gefitinib is recommended as a first-line treatment option for elderly patients with non-small cell lung cancer (NSCLC). Because no pharmacokinetics of gefitinib have been examined, we prospectively assessed the pharmacokinetics of
Externí odkaz:
https://doaj.org/article/d782a4040fdf4d7288eb955e6906f4fd
Autor:
Jun Arai, Yumi Otoyama, Ken-ichi Fujita, Kaku Goto, Masayuki Tojo, Atsushi Katagiri, Hisako Nozawa, Yutaro Kubota, Takehiro Takahashi, Hiroo Ishida, Takuya Tsunoda, Natsumi Matsumoto, Keita Ogawa, Ryo Nakagawa, Ryosuke Muroyama, Naoya Kato, Hitoshi Yoshida
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined whether its plasma levels were associated with regorafenib activity in
Externí odkaz:
https://doaj.org/article/beacc506008f4c9b88f6ed901d1eff5b
Publikováno v:
European Journal of Breast Health, Vol 18, Iss 2, Pp 155-162 (2022)
Objective:Recently, personal health records (PHR) have become a communication tool between patients and medical professionals. PHR applications (PHR app) can be installed on smartphones to record patient-reported outcomes (PROs). This study prospecti
Externí odkaz:
https://doaj.org/article/e8437e85fa154be4ab97297cfff63e47
Autor:
Koki Katayama, Shimon Nakashima, Hiroo Ishida, Yutaro Kubota, Masataka Nakano, Tatsuki Fukami, Yasutsuna Sasaki, Ken-ichi Fujita, Miki Nakajima
Publikováno v:
Non-coding RNA Research, Vol 6, Iss 3, Pp 123-129 (2021)
Single nucleotide polymorphisms in genes encoding microRNAs (miRNA-SNPs) may affect the maturation steps of miRNAs or target mRNA recognition, leading to changes in the expression of target mRNAs to cause gain- or loss-of-function changes. Several mi
Externí odkaz:
https://doaj.org/article/19faf567fce240339e0b270504a3c810
Autor:
Masashi Kurata, Naoko Fujiwara, Ken-ichi Fujita, Yasutaka Yamanaka, Shigeto Seno, Hisato Kobayashi, Yusaku Miyamae, Nobuyuki Takahashi, Yasuyuki Shibuya, Seiji Masuda
Publikováno v:
iScience, Vol 22, Iss , Pp 336-352 (2019)
Summary: Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. The
Externí odkaz:
https://doaj.org/article/bb48bc0c6e8646a4975788810fc713c3
Autor:
Ken-ichi FUJITA, Harumi YASHIRO
Publikováno v:
Journal of Structural Engineering B. :140-150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c4e9248561d2b004cca7a0f71af0b65
https://doi.org/10.3130/aijjse.69b.0_140
https://doi.org/10.3130/aijjse.69b.0_140