Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Ken Yamada"'
Autor:
James W. Gilbert, Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, David Cooper, Ken Yamada, Matthew Hassler, Hélène Tran, Fen Biao Gao, Robert H. Brown, Jr., Anastasia Khvorova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102291- (2024)
A hexanucleotide (G4C2) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). C9ORF72 haploinsufficiency, formation of RNA foci, and production of di
Externí odkaz:
https://doaj.org/article/48f420ec0d5f4364889fb47b75a6618c
Autor:
Vignesh N. Hariharan, Takahiro Nakamura, Minwook Shin, Qi Tang, Vyankat Sontakke, Jillian Caiazzi, Samuel Hildebrand, Anastasia Khvorova, Ken Yamada
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102230- (2024)
Small interfering RNAs (siRNAs) are revolutionizing the treatment of liver-associated indications. Yet, robust delivery to extrahepatic tissues remains a challenge. Conjugating lipids (e.g., docosanoic acid [DCA]) to siRNA supports extrahepatic deliv
Externí odkaz:
https://doaj.org/article/11b7081549e04a32bb58409f85966f34
Autor:
Faith Conroy, Rachael Miller, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Bruno M. D. C. Godinho, Emily G. Knox, Ellen Sapp, Jaquelyn Sousa, Ken Yamada, Farah Mahmood, Adel Boudi, Kimberly Kegel-Gleason, Marian DiFiglia, Neil Aronin, Anastasia Khvorova, Edith L. Pfister
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Chemically modified siRNAs distinguish between mutant and normal huntingtin based on a single nucleotide difference and lower mutant huntingtin specifically in patient derived cells and in a mouse model of Huntington’s disease.
Externí odkaz:
https://doaj.org/article/b3726cec35ca4048a177c94f5d18c4bd
Publikováno v:
Applied Sciences, Vol 10, Iss 21, p 7709 (2020)
Selective chemical reactions of biomolecules are some of the important tools for investigations by biological studies. We have developed the selective crosslinking reactions to form covalent bonds to DNA or RNA using crosslinking oligonucleotides (CF
Externí odkaz:
https://doaj.org/article/2d6dd9ef7e3c4475bcb8b363b61b32ce
Autor:
Elena Moroz, Soo Hyeon Lee, Ken Yamada, François Halloy, Saúl Martínez-Montero, Hartmut Jahns, Jonathan Hall, Masad J Damha, Bastien Castagner, Jean-Christophe Leroux
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Nucleic acid therapy can be beneficial for the local treatment of gastrointestinal diseases that currently lack appropriate treatments. Indeed, several oligonucleotides (ONs) are currently progressing through clinical trials as potential treatments f
Externí odkaz:
https://doaj.org/article/a4adba38bc78417ebcd5e8745c9d45ac
Publikováno v:
Tricycle: The Buddhist Review; Spring2024, Vol. 33 Issue 3, p48-101, 4p, 3 Color Photographs
Autor:
Shiori Yamamoto, Shin-ichiro Akimoto, Chiaki Sakoi, Ken Yamada, Hidenori Kabeya, Hiromu Sugiyama, Shinji Takai, Ken Maeda, Hiroshi Asakura
Publikováno v:
Japanese Journal of Food Microbiology. 39:77-82
Publikováno v:
Weather and Forecasting.
The seasonal predictability of the Rossby wave breaking (RWB) frequency near Japan in July–August (JA) is examined using daily JMA/MRI-CPS3 (CPS3) hindcast data, which is an operational seasonal prediction system of the Japan Meteorological Agency.
Autor:
Vignesh N. Hariharan, Minwook Shin, Ching-Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada, Zhiru Guo, Mohan Somasundaran, Qi Tang, Kathryn Monopoli, Pranathi Meda Krishnamurthy, Gitali Devi, Nicholas McHugh, David A. Cooper, Dimas Echeverria, John Cruz, Io Long Chan, Ping Liu, Sun-Young Lim, Jill McConnell, Satya Prakash Singh, Samuel Hildebrand, Jacquelyn Sousa, Sarah M. Davis, Zachary Kennedy, Chantal Ferguson, Bruno M. D. C. Godinho, Yann Thillier, Jillian Caiazzi, Socheata Ly, Manish Muhuri, Karen Kelly, Fiachra Humphries, Alyssa Cousineau, Krishna Mohan Parsi, Qi Li, Yang Wang, René Maehr, Guangping Gao, Dmitry Korkin, William M. McDougall, Robert W. Finberg, Katherine A. Fitzgerald, Jennifer P. Wang, Jonathan K. Watts, Anastasia Khvorova
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid development of pan-viral variant therapeutics. Oligonucleotide therapeutics are enhancing t
Autor:
Ellen Sapp, Dimas Echeverria, Neil Aronin, Edith L. Pfister, Matthew R. Hassler, Samuel F. Hildebrand, Anastasia Khvorova, Jillian Caiazzi, Ken Yamada, Loic Roux, Rachael Miller, Faith Conroy, Julia F. Alterman, Marian DiFiglia, Sarah M. Davis
Publikováno v:
Nucleic Acids Research
Oligonucleotides is an emerging class of chemically-distinct therapeutic modalities, where extensive chemical modifications are fundamental for their clinical applications. Inter-nucleotide backbones are critical to the behaviour of therapeutic oligo