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Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors

Autor: Ken Wills, Daniel Mahony, Emma Lees, David A.D. Parry

Publikováno v: Molecular and Cellular Biology. 19:1775-1783

The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G0-G1-S progression by contributing to the phosphorylation and inactivation of the retinoblastoma gene product, pRB. Assembly of active cyclin D-CDK complexes in response to mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce2d56e0f579259231ca476ff79d14d
https://doi.org/10.1128/mcb.19.3.1775

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Immunogenicity in mice and rabbits of DNA vaccines expressing woodchuck hepatitis virus antigens

Autor: Paul J. Cote, Bud C. Tennant, Stephan Menne, Robert M. Bernard, Alain Luxembourg, Drew Hannaman, Ken Wills

Publikováno v: Vaccine. 26(32)

The licensed vaccine against hepatitis B virus (HBV) is an effective means to prevent infection, but is not an effective therapeutic strategy to treat established chronic infections when used alone. In an animal model of chronic HBV infection (the wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975d3db0b480cc24e8006352a912498a
https://pubmed.ncbi.nlm.nih.gov/18556096

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Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis

Autor: Murali, Ramachandra, Isabella, Atencio, Amena, Rahman, Mei, Vaillancourt, Aihua, Zou, Jenny, Avanzini, Ken, Wills, Robert, Bookstein, Paul, Shabram

Publikováno v: Cancer research. 62(21)

Smad proteins transduce signals carried by the transforming growth factor beta (TGF-beta) cytokine superfamily from receptor serine/threonine kinases at the cell surface to the nucleus, thereby affecting cell proliferation, differentiation, as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5155ba1d73e7d0d06c166b0c3e76c60
https://pubmed.ncbi.nlm.nih.gov/12414627

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