Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ken Shimamura"'
Publikováno v:
Peptides. 30:1529-1538
Chemerin is a novel peptide that was identified as a natural ligand for ChemR23. As it has been reported to be involved in the regulation of immune responses and adipogenesis, chemerin may have a variety of physiological functions. Chemerin is synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f298c28aa666c0e026384fca5f9d31
https://doi.org/10.1016/j.peptides.2009.05.030
https://doi.org/10.1016/j.peptides.2009.05.030
Autor:
Ken Shimamura, Katsumi Aragane, Toshiyuki Takahashi, Maki Kanesaka, Yasuhisa Miyamoto, Shigeru Tokita, Takahide Sasaki, Tsuyoshi Nagase, Ryo Yoshimoto, Hidefumi Kitazawa, Nagaaki Sato, Akira Nagumo
Publikováno v:
Journal of Medicinal Chemistry. 52:4111-4114
Long chain fatty acid elongase 6 (ELOVL6) catalyzes the elongation of long chain fatty acyl-CoAs and is a potential target for the treatment of metabolic disorders. The ultrahigh throughput screen of our corporate chemical collections resulted in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464844a9a0dc51ceb1eda04f4e37e2b
https://doi.org/10.1021/jm900488k
https://doi.org/10.1021/jm900488k
Publikováno v:
European Journal of Pharmacology. 486:141-150
We investigated the effects of sphingosine 1-phosphate and histamine on the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin, and their signaling pathways in human umbilical vein endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9500ad7b0f229bc768b4795c9b96cbf4
https://doi.org/10.1016/j.ejphar.2003.12.022
https://doi.org/10.1016/j.ejphar.2003.12.022
Publikováno v:
Energy & Fuels. 12:734-739
Anhydrous hydrogen fluoride (HF) alone or combined with a small proportion of boron trifluoride (BF3) desulfurized high-sulfur coal in the presence of hydrocarbons without H2 in mild reaction conditions. HF removed mainly sulfidic and oxidized sulfur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03145e5b986176032dac47704d8276e9
https://doi.org/10.1021/ef9702097
https://doi.org/10.1021/ef9702097
Autor:
Yasuhisa Miyamoto, Ken Shimamura, Hidefumi Kitazawa, Naomi Morita, Shigeru Tokita, Katsumi Aragane, Toshiyuki Takahashi, Tomoyuki Ohe, Nagaaki Sato, Ryo Yoshimoto, Tsuyoshi Nagase, Maki Kanesaka, Akira Nagumo
Publikováno v:
European journal of pharmacology. 630(1-3)
The elongase of long chain fatty acids family 6 (ELOVL6) is a rate-limiting enzyme for the elongation of saturated and monounsaturated long chain fatty acids. ELOVL6 is abundantly expressed in lipogenic tissues such as liver, and its mRNA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5964cf4f3326a726a3f491c4666a977
https://pubmed.ncbi.nlm.nih.gov/20045404
https://pubmed.ncbi.nlm.nih.gov/20045404
Autor:
Yasuhisa Miyamoto, Nagaaki Sato, Hidekazu Takahashi, Dennis C. Dean, Akira Nagumo, Shigeru Tokita, Cheng Tang, Tsuyoshi Nagase, Hidefumi Kitazawa, Ken Shimamura
Publikováno v:
Journal of biochemistry. 146(3)
ELOVL6, a member of the elongation of very long-chain fatty acids (ELOVL) family, has recently been identified as the rate-limiting enzyme for the elongation of palmitoyl-CoA. ELOVL6 deficient mice are protected from high-fat diet induced insulin res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b156ad90c6c1afe61b0558d0e5137dc
https://pubmed.ncbi.nlm.nih.gov/19505953
https://pubmed.ncbi.nlm.nih.gov/19505953
Autor:
Hidefumi Kitazawa, Ken Shimamura, Shigeru Tokita, Hidehito Kotani, Yasuhisa Miyamoto, Tsutomu Kobayashi
Publikováno v:
Assay and drug development technologies. 7(2)
Elongase of very-long-chain fatty acid (Elovl) 6 is a rate-limiting enzyme that is responsible for the elongation of long-chain fatty acids such as palmitoic acid (C16). Elovl6 is abundantly expressed in liver and adipose tissue, and the expression l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ef5e83d6cc77a4b3e8a91a2414221d
https://pubmed.ncbi.nlm.nih.gov/19505229
https://pubmed.ncbi.nlm.nih.gov/19505229
Autor:
Takahide Sasaki, Akira Nagumo, Ryo Yoshimoto, Toshiyuki Takahashi, Hidefumi Kitazawa, Yasuhisa Miyamoto, Shigeru Tokita, Maki Kanesaka, Katsumi Aragane, Ken Shimamura, Nagaaki Sato, Tsuyoshi Nagase
Publikováno v:
Journal of medicinal chemistry. 52(10)
Novel indoledione derivatives were synthesized and evaluated as long chain fatty acid elongase 6 (ELOVL6) inhibitors. Systematic optimization of an indole class of lead 1 led to the identification of potent ELOVL6 selective inhibitors. Representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854125f535cc19905af67196bd550649
https://pubmed.ncbi.nlm.nih.gov/19388647
https://pubmed.ncbi.nlm.nih.gov/19388647
Autor:
Hidefumi Kitazawa, Tsuyoshi Nagase, Takahide Sasaki, Ken Shimamura, Maki Kanesaka, Ryo Yoshimoto, Yasuhisa Miyamoto, Katsumi Aragane, Akira Nagumo, Nagaaki Sato, Toshiyuki Takahashi, Shigeru Tokita
Publikováno v:
Bioorganicmedicinal chemistry. 17(15)
A series of novel 2-azabicyclo[2.2.2]octane derivatives was synthesized and evaluated as long chain fatty acid elongase 6 (ELOVL6) inhibitors. Screening of our corporate chemical collections against ELOVL6 resulted in the identification of lead 1. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0277260723861742e02f860efc674f
https://pubmed.ncbi.nlm.nih.gov/19596583
https://pubmed.ncbi.nlm.nih.gov/19596583
Autor:
Tsuyoshi Nagase, Yasuhisa Miyamoto, Hidefumi Kitazawa, Shigeru Tokita, Naomi Morita, Ken Shimamura, Ryo Yoshimoto, Katsumi Aragane, Toshiyuki Takahashi, Akira Nagumo, Maki Kanesaka, Tomoyuki Ohe, Nagaaki Sato
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 330(1)
Long-chain fatty acid elongases reside in the endoplasmic reticulum and are responsible for the rate-limiting step of the elongation of long-chain fatty acids. The elongase of long-chain fatty acids (ELOVL) family 6 (ELOVL6) is involved in the elonga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e60e74a3833aaa37b7fd872649d97a2
https://pubmed.ncbi.nlm.nih.gov/19359527
https://pubmed.ncbi.nlm.nih.gov/19359527