Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ken Raj"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Evidence suggests that exposure to UV-A radiation can liberate nitric oxide from skin cells eliciting vasodilation in-vivo. However, the duration of nitric oxide release in skin cells after UV exposure is not well studied, with emphasis on U
Externí odkaz:
https://doaj.org/article/73d89ba77c5841ea8738d78040ac5e30
Autor:
Steve Horvath, Amin Haghani, Sichong Peng, Erin N. Hales, Joseph A. Zoller, Ken Raj, Brenda Larison, Todd R. Robeck, Jessica L. Petersen, Rebecca R. Bellone, Carrie J. Finno
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Methylation levels of specific sites in the genome is correlated with aging. Here the authors develop a human-horse clock which could assist in translating anti-aging interventions from humans to horses and vice versa.
Externí odkaz:
https://doaj.org/article/b6d84436d0aa47928604d293e0954a71
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101378- (2022)
Summary: We have developed a technique to isolate primary keratinocytes, melanocytes, fibroblasts, preadipocytes, and microvascular endothelial cells from an individual sample of human skin. The protocol describes step-by-step instructions for proces
Externí odkaz:
https://doaj.org/article/c9a935c65fcb4a0abd8fb375a66e75f7
Autor:
Steve Horvath, Amin Haghani, Joseph A. Zoller, Ken Raj, Ishani Sinha, Todd R. Robeck, Pete Black, Aidan Couzens, Clive Lau, Meghety Manoyan, Yadiamaris Aviles Ruiz, Annais Talbott, Katherine Belov, Carolyn J. Hogg, Karen E. Sears
Publikováno v:
GeroScience, vol 44, iss 3
The opossum (Monodelphis domestica), with its sequenced genome, ease of laboratory care and experimental manipulation, and unique biology, is the most used laboratory marsupial. Using the mammalian methylation array, we generated DNA methylation data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8de9025e26109ad697e290d98d3a1e
https://doi.org/10.1007/s11357-022-00569-5
https://doi.org/10.1007/s11357-022-00569-5
Autor:
Steve Horvath, Amin Haghani, Nicholas Macoretta, Julia Ablaeva, Joseph A. Zoller, Caesar Z. Li, Joshua Zhang, Masaki Takasugi, Yang Zhao, Elena Rydkina, Zhihui Zhang, Stephan Emmrich, Ken Raj, Andrei Seluanov, Chris G. Faulkes, Vera Gorbunova
Publikováno v:
Nature Aging. 2:46-59
Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related decline in physiological capacity and are resistant to age-related diseases. However, it has been unknown whether NMRs also evade aging according to a primary h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4932d83181c569d88474fe3cc5c815
https://doi.org/10.1038/s43587-021-00152-1
https://doi.org/10.1038/s43587-021-00152-1
Autor:
Dhanansayan Shanmuganayagam, Kyle M. Schachtschneider, Ken Raj, Joshua Zhang, Andrew Yang, Amin Haghani, Caesar Z. Li, Lawrence B. Schook, Steve Horvath, Joseph A. Zoller, Jennifer J. Meudt
Publikováno v:
GeroScience, vol 43, iss 5
GeroScience
GeroScience
DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n = 238 porcine tissues including blood,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd972fe1cd89e4e7fe0351b130cb239
https://doi.org/10.1007/s11357-021-00439-6
https://doi.org/10.1007/s11357-021-00439-6
Autor:
Pete Black, Dewey Maddox, Caesar Z. Li, Balazs Szladovits, Todd R. Robeck, Ken Raj, Amin Haghani, Joseph A. Zoller, Steve Horvath
Publikováno v:
GeroScience
GeroScience, vol 43, iss 5
GeroScience, vol 43, iss 5
Human DNA methylation profiles have been used successfully to develop highly accurate biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not immediately applicable to all species of the animal kingdom, the princ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db214051e0ebc17be5939a2759852af
https://doi.org/10.1007/s11357-021-00445-8
https://doi.org/10.1007/s11357-021-00445-8
Autor:
Steve Horvath, Ake T. Lu, Amin Haghani, Joseph A. Zoller, Caesar Z. Li, Andrea R. Lim, Robert T. Brooke, Ken Raj, Aitor Serres-Armero, Dayna L. Dreger, Andrew N. Hogan, Jocelyn Plassais, Elaine A. Ostrander
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(21)
DNA methylation profiles have been used to develop biomarkers of aging known as epigenetic clocks, which predict chronological age with remarkable accuracy and show promise for inferring health status as an indicator of biological age. Epigenetic clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b6555e03db098e5a27cc7557cacaec
https://pubmed.ncbi.nlm.nih.gov/35580182
https://pubmed.ncbi.nlm.nih.gov/35580182
Autor:
Ken Raj, Steve Horvath
Publikováno v:
Exp Biol Med (Maywood)
It has been noted for quite some time that DNA methylation levels decline with age. The significance of this change remained unknown until it became possible to measure methylation status of specific sites on the DNA. It was observed that while the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa32d34e0cee39dfd26f517c1ca84c7
https://doi.org/10.1177/1535370220918329
https://doi.org/10.1177/1535370220918329
Evidence suggests that exposure to the UV-A radiation can liberate nitric oxide from skin cells eliciting vasodilation in-vivo. However, the duration of nitric oxide release in skin cells after UV exposure is not well studied, with emphasis on UV-B m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71232a3490c71073d0f45d028f750ad5
https://doi.org/10.21203/rs.3.rs-1188300/v1
https://doi.org/10.21203/rs.3.rs-1188300/v1
