Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ken R. Harrap"'
Autor:
Ken R. Harrap, Mark J. McKeage, John Bridgewater, Roger A'Hern, Cyril Fisher, John B. Schofield, Lloyd R. Kelland, Ian Jacobs, Jenny C. Chang, Martin Gore, Bruce A.J. Ponder
Publikováno v:
The Lancet. 343:335-340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28c903d87aeba06f811f0dabcdef5af1
https://doi.org/10.1016/s0140-6736(94)91168-1
https://doi.org/10.1016/s0140-6736(94)91168-1
Publikováno v:
International journal of cancer. 59(1)
Acquired resistance to tetraplatin [d,1-trans-1,2-diaminocy-clohexane tetrachloroplatinum (IV)] has been generated in vitro in the human ovarian carcinoma cell line PXN94; the derived line, PXN94tetR, was 24-fold resistant to tetraplatin. Intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3256a7191b5195365b61f9d76817c35b
https://pubmed.ncbi.nlm.nih.gov/7927906
https://pubmed.ncbi.nlm.nih.gov/7927906
Publikováno v:
International journal of cancer. 55(5)
Glutathione (GSH) has often been implicated in the mechanism of resistance to platinum anti-cancer drugs. It has been suggested that GSH may reduce the cytotoxicity of these drugs by forming inactive conjugates and by enhancing the repair of DNA-plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcd771ade45e1119aa2fbe9927646d6
https://pubmed.ncbi.nlm.nih.gov/8244583
https://pubmed.ncbi.nlm.nih.gov/8244583
Autor:
Barry A. Murrer, Lloyd R. Kelland, Giandomenico Christen M, Rosanne M. Orr, T. Cobbleigh, Mervyn Jones, Phyllis M. Goddard, Sarah E. Morgan, Ken R. Harrap, Michael J. Abrams
Publikováno v:
Advances in enzyme regulation. 31
In the search for a platinum complex capable of oral administration, the poor bioavailability of established drugs has been circumvented by the discovery of a novel class of platinum (IV) ammine/amine dicarboxylate dichlorides. These compounds, when
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69ba3ba20af4c80ce63f1cfb50e18c2
https://pubmed.ncbi.nlm.nih.gov/1877393
https://pubmed.ncbi.nlm.nih.gov/1877393
Publikováno v:
Biochemical pharmacology. 23(6)
Of 25 compounds tested, eight—namely, 5-azacytidine, gougerotin, cycloheximide, pactamyein, streptovitaein A, adriamyein, daunoruhicin and thioacetamide resulted in the enhancement of liver uridine kinase actiuty in vivo . Puromycin and actinomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15a552313d2381b1123fdcaa6684651
https://pubmed.ncbi.nlm.nih.gov/4132959
https://pubmed.ncbi.nlm.nih.gov/4132959