Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ken R, Walder"'
Autor:
Liam G. Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A. Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. The role of amyloid beta 42 (Aβ42) in these diverse chronic diseases is obscure. Here we show that adipose tissue
Externí odkaz:
https://doaj.org/article/ade282758ba44938be3e4d25c0c6bdc1
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Autor:
Sheree D. Martin, Timothy Connor, Andrew Sanigorski, Kevin A. McEwen, Darren C. Henstridge, Brunda Nijagal, David De Souza, Dedreia L. Tull, Peter J. Meikle, Greg M. Kowalski, Clinton R. Bruce, Paul Gregorevic, Mark A. Febbraio, Fiona M. Collier, Ken R. Walder, Sean L. McGee
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)
Abstract Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased h
Externí odkaz:
https://doaj.org/article/cb089318d6ca4cdc83eb1a778a2e7a37
Autor:
Stewart WC Masson, Søren Madsen, Kristen C Cooke, Meg Potter, Alexis Diaz Vegas, Luke Carroll, Senthil Thillainadesan, Harry B Cutler, Ken R Walder, Gregory J Cooney, Grant Morahan, Jacqueline Stöckli, David E James
Publikováno v:
eLife, Vol 12 (2023)
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. ‘Diversity Outbred in Australia (DOz)’ is a population of genetically unique mice with profou
Externí odkaz:
https://doaj.org/article/b8bfc06ac64146cfa4af3ab8d745020e
Autor:
Vidhi Gaur, Timothy Connor, Andrew Sanigorski, Sheree D. Martin, Clinton R. Bruce, Darren C. Henstridge, Simon T. Bond, Kevin A. McEwen, Lyndal Kerr-Bayles, Trent D. Ashton, Cassandra Fleming, Min Wu, Lisa S. Pike Winer, Denise Chen, Gregg M. Hudson, John W.R. Schwabe, Keith Baar, Mark A. Febbraio, Paul Gregorevic, Frederick M. Pfeffer, Ken R. Walder, Mark Hargreaves, Sean L. McGee
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2802-2810 (2016)
Drugs that recapitulate aspects of the exercise adaptive response have the potential to provide better treatment for diseases associated with physical inactivity. We previously observed reduced skeletal muscle class IIa HDAC (histone deacetylase) tra
Externí odkaz:
https://doaj.org/article/edcebf20f6354f6bb76e658132df2dd0
Autor:
Liam G Hall, Juliane K. Czeczor, Timothy Connor, Javier Botella, Kirstie A. De Jong, Mark C. Renton, Amanda J. Genders, Kylie Venardos, Sheree D. Martin, Simon T. Bond, Kathryn Aston-Mourney, Kirsten F. Howlett, James A Campbell, Greg R. Collier, Ken R. Walder, Matthew McKenzie, Mark Ziemann, Sean L. McGee
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. While some common aetiological mechanisms are known, the role of amyloid beta 42 (Aβ42) in these diverse chronic diseases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7713650f077407ca0d354131f4b65baa
https://doi.org/10.1101/2022.10.02.510555
https://doi.org/10.1101/2022.10.02.510555
Autor:
Vidhi, Gaur, Timothy, Connor, Kylie, Venardos, Darren C, Henstridge, Sheree D, Martin, Courtney, Swinton, Shona, Morrison, Kathryn, Aston-Mourney, Stefan M, Gehrig, Roelof, van Ewijk, Gordon S, Lynch, Mark A, Febbraio, Gregory R, Steinberg, Mark, Hargreaves, Ken R, Walder, Sean L, McGee
Publikováno v:
Diabetes, obesitymetabolism. 19(7)
To determine the effect of Scriptaid, a compound that can replicate aspects of the exercise adaptive response through disruption of the class IIa histone deacetylase (HDAC) corepressor complex, on muscle insulin action in obesity.Diet-induced obese m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::257d9cc9fa6cc3050e07109953017b90
https://pubmed.ncbi.nlm.nih.gov/28155245
https://pubmed.ncbi.nlm.nih.gov/28155245