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Early steps in thermal unfolding of superoxide dismutase 1 are similar to the conformational changes associated with the ALS-associated A4V mutation

Autor: Valerie Daggett, Ken Ploeger, Amanda L. Jonsson, Tom Schmidlin

Publikováno v: Protein engineering, designselection : PEDS. 26(8)

There are over 100 mutations in Cu/Zn superoxide dismutase (SOD1) that result in a subset of familial amyotrophic lateral sclerosis (fALS) cases. The hypothesis that dissociation of the dimer, misfolding of the monomer and subsequent aggregation of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad37792a87c0a4575e8e300be03fe28
https://pubmed.ncbi.nlm.nih.gov/23784844

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