Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ken N Seergobin"'
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
Dopaminergic therapy has paradoxical effects on cognition in Parkinson’s disease (PD) patients, with some functions worsened and others improved. The dopamine overdose hypothesis is proposed as an explanation for these opposing effects of medicatio
Externí odkaz:
https://doaj.org/article/97754bcb20a846758dec5bcb0e2982aa
Autor:
Erind Alushaj, Dimuthu Hemachandra, Hooman Ganjavi, Ken N. Seergobin, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R. Khan, Penny A. MacDonald
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Idiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson’s disease (PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars compacta (SNc) degeneration underlies motor symptoms of PD. In
Externí odkaz:
https://doaj.org/article/39e858f28c174edebc48170f23ffe471
Autor:
Alex A MacDonald, Ken N Seergobin, Adrian M Owen, Ruzbeh Tamjeedi, Oury Monchi, Hooman Ganjavi, Penny A MacDonald
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74044 (2013)
Increasingly memory deficits are recognized in Parkinson's disease (PD). In PD, the dopamine-producing cells of the substantia nigra (SN) are significantly degenerated whereas those in the ventral tegmental area (VTA) are relatively spared. Dopamine-
Externí odkaz:
https://doaj.org/article/8b60f4b410fb4727b021fc26e42e8a7f
Autor:
Abdullah Al Jaja, Téa Sue, Margaret Prenger, Ken N. Seergobin, Jessica A. Grahn, Penny A. MacDonald
Publikováno v:
Parkinson's Disease, Vol 2024 (2024)
Background. Freezing of gait (FOG) is an intractable motor symptom in Parkinson’s disease (PD) that increases fall risk and impairs the quality of life. FOG has been associated with anxiety, with experimental support for the notion that anxiety its
Externí odkaz:
https://doaj.org/article/6096c03cb4984144aa55c768f773f884
Publikováno v:
Abstracts of the 26th Annual Meeting of the GCMAS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef52c1a45421765c025305fe93cf7958
https://doi.org/10.52141/gcmas2021_169
https://doi.org/10.52141/gcmas2021_169
Publikováno v:
Neurobiology of Aging. 69:129-139
The dopamine overdose hypothesis has provided an important theoretical framework for understanding cognition in Parkinson's disease. It posits that effects of dopaminergic therapy on cognition in Parkinson's disease depend on baseline dopamine levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991d0f5a7020c3dab71ff6b65a1aeb6d
https://doi.org/10.1016/j.neurobiolaging.2018.05.014
https://doi.org/10.1016/j.neurobiolaging.2018.05.014
Publikováno v:
Human Brain Mapping. 38:6133-6156
We investigated a controversy regarding the role of the dorsal striatum (DS) in deliberate decision-making versus late-stage, stimulus-response learning to the point of automatization. Participants learned to associate abstract images with right or l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a201d3923edf4095e129d906d83dfaa3
https://doi.org/10.1002/hbm.23817
https://doi.org/10.1002/hbm.23817
Autor:
Nole M. Hiebert, Marc R. Lawrence, Hooman Ganjavi, Mark Watling, Adrian M. Owen, Ken N. Seergobin, Penny A. MacDonald
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 11 (2020)
Brain and Mind Institute Researchers' Publications
Frontiers in Psychiatry, Vol 11 (2020)
Brain and Mind Institute Researchers' Publications
© Copyright © 2020 Hiebert, Lawrence, Ganjavi, Watling, Owen, Seergobin and MacDonald. Obsessive compulsive disorder (OCD) is a prevalent psychiatric disorder characterized by obsessions and compulsions. Studies investigating symptomatology and cog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2048e528527172dbbe2fb50cef27c21c
https://pubmed.ncbi.nlm.nih.gov/32116835
https://pubmed.ncbi.nlm.nih.gov/32116835
Autor:
Nole M. Hiebert, Adrian M. Owen, Mary E. Jenkins, Penny A. MacDonald, Daniel Mendonca, Hooman Ganjavi, Ken N. Seergobin
Publikováno v:
Brain and Mind Institute Researchers' Publications
© 2018 Learning associations between stimuli and responses is essential to everyday life. Dorsal striatum (DS) has long been implicated in stimulus-response learning, though recent results challenge this contention. We have proposed that discrepant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891ce7cfd9be6e3affe220f2a03effd5
https://pubmed.ncbi.nlm.nih.gov/30394326
https://pubmed.ncbi.nlm.nih.gov/30394326
Autor:
Brian D. Robertson, Abdullah S. Al Jaja, Alex A. MacDonald, Nole M. Hiebert, Ruzbeh Tamjeedi, Ken N. Seergobin, Ute I. Schwarz, Richard B. Kim, Penny A. MacDonald
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Frontiers in Neurology
Brain and Mind Institute Researchers' Publications
Frontiers in Neurology
Brain and Mind Institute Researchers' Publications
In Parkinson's disease (PD), cognitive functions mediated by brain regions innervated by ventral tegmental area (VTA) worsen with dopamine replacement therapy, whereas processes relying on regions innervated by the substantia nigra pars compacta (SNc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0278a6fd9e7edb94ead5f16175bf0
https://www.frontiersin.org/article/10.3389/fneur.2018.00693/full
https://www.frontiersin.org/article/10.3389/fneur.2018.00693/full