STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Autor: Weiqun Liu, Joshua J. Woodward, Peter Lauer, Justin Leong, Juan Fu, David B. Kanne, Qi Zeng, Thomas W. Dubensky, Daniel A. Portnoy, Ken Mechette, Lei Zheng, Kevin C. Soares, Laura Hix Glickman, Sarah M. McWhirter, Young J. Kim, Drew M. Pardoll, Kelsey E. Sivick, Meredith L. Leong, Edward E. Lemmens

Publikováno v: Science translational medicine, vol 7, iss 283
Fu, J; Kanne, DB; Leong, M; Glickman, LH; McWhirter, SM; Lemmens, E; et al.(2015). STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Science Translational Medicine, 7(283). doi: 10.1126/scitranslmed.aaa4306. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1c28g834

Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 (signal tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821f1f0a60e37dfde8a677cf720d728e
https://escholarship.org/uc/item/1c28g834