Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ken M. Simpson"'
Autor:
Chelsee A Hewitt, King-Hwa Ling, Tobias D Merson, Ken M Simpson, Matthew E Ritchie, Sarah L King, Melanie A Pritchard, Gordon K Smyth, Tim Thomas, Hamish S Scott, Anne K Voss
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11561 (2010)
BackgroundDown syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease.Methodology/principal findingsTo understand how trisomy 21 causes these neurological abnormalities we investigated c
Externí odkaz:
https://doaj.org/article/9f51062a00a048609ce9234d5876a4cf
Publikováno v:
PLoS Pathogens, Vol 1, Iss 4, p e37 (2005)
Central to the pathology of malaria disease are the repeated cycles of parasite invasion and destruction of human erythrocytes. In Plasmodium falciparum, the most virulent species causing malaria, erythrocyte invasion involves several specific recept
Externí odkaz:
https://doaj.org/article/ad5b7823e6324d9c8c9c6db5ed348bb7
Publikováno v:
European Journal of Immunology. 37:1864-1873
Rapid production of interferon-gamma (IFN-gamma) in response to malaria by the innate immune system may determine resistance to infection, or inflammatory disease. However, conflicting reports exist regarding the identity of IFN-gamma-producing cells
Autor:
Robert T. Good, Elizabeth A. Winzeler, Terence P. Speed, Ken M. Simpson, Jacob Baum, Alan F. Cowman
Publikováno v:
International Journal for Parasitology. 35:523-531
This study is motivated by two data sets which employ a custom Plasmodium falciparum version of the Affymetrix GeneChip ® , containing only perfect match (PM) oligonucleotides. A PM-only chip cannot be analysed using the standard Affymetrix-supplied
Autor:
King Hwa Ling, Tim Thomas, Kai-Leng Tan, Pike See Cheah, Chelsee A. Hewitt, Melanie April Pritchard, Lavinia Gordon, Hamish S. Scott, Gordon K. Smyth, Ken M. Simpson
Publikováno v:
Genomics Data
Genomics Data, Vol 2, Iss C, Pp 314-317 (2014)
Genomics Data, Vol 2, Iss C, Pp 314-317 (2014)
The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar v
Publikováno v:
Bioinformatics. 22:897-899
Summary: affylmGUI is a graphical user interface (GUI) to an integrated workflow for Affymetrix microarray data. The user is able to proceed from raw data (CEL files) to QC and pre-processing, and eventually to analysis of differential expression usi
Autor:
Nicolette, Binz, Ireni S, Ali Rahman, Holly R, Chinnery, Richard, McKeone, Ken M, Simpson, Terence P, Speed, Chooi-May, Lai, P Elizabeth, Rakoczy
Publikováno v:
Clinicalexperimental ophthalmology. 41(3)
The Kimba mouse carries a human vascular endothelial growth factor transgene causing retinal neovascularisation similar to that seen in diabetic retinopathy. Here, we examine the relationship between differential gene expression induced by vascular e
Autor:
Gordon K. Smyth, Matthew E. Ritchie, Hamish S. Scott, Tobias D. Merson, Chelsee A. Hewitt, Melanie April Pritchard, Ken M. Simpson, Sarah L. King, Anne K. Voss, Tim Thomas, King Hwa Ling
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 7, p e11561 (2010)
PLoS ONE, Vol 5, Iss 7, p e11561 (2010)
BackgroundDown syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease.Methodology/principal findingsTo understand how trisomy 21 causes these neurological abnormalities we investigated c
Autor:
Terence P. Speed, Ken M. Simpson, Mark D. Robinson, J. G. Conboy, Elizabeth Purdom, Anna Lapuk
Publikováno v:
Bioinformatics
Motivation: Analyses of EST data show that alternative splicing is much more widespread than once thought. The advent of exon and tiling microarrays means that researchers now have the capacity to experimentally measure alternative splicing on a geno
Autor:
Terence P. Speed, Julia Brettschneider, Leslie Cope, Francois Collin, Benjamin M. Bolstad, Rafael A. Irizarry, Ken M. Simpson
Publikováno v:
Bioinformatics and Computational Biology Solutions Using R and Bioconductor ISBN: 0387251464
This chapter covers quality assessment for Affymetrix GeneChip data. The focus is on procedures available from the affy and affy-PLM packages. Initially some exploratory plots provided by the affy package, including images of the raw probe-level data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d6fe712525c1ebe607f5fda77f6d9b7
https://doi.org/10.1007/0-387-29362-0_3
https://doi.org/10.1007/0-387-29362-0_3