Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ken Lind"'
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
Autor:
David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-16 (2021)
Abstract Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have use
Externí odkaz:
https://doaj.org/article/73075a476ae1421891a994ecbcb35e20
Autor:
Xinrong Tian, Dominic Suarez, Douglas Thomson, William Li, Elizabeth A. King, Louis LaFrance, Jeffrey Boehm, Linda Barton, Christina Di Marco, Cuthbert Martyr, Reema Thalji, Jesus Medina, Steven Knight, Dirk Heerding, Enoch Gao, Eldridge Nartey, Ted Cecconie, Christopher Nixon, Guofeng Zhang, Thomas J. Berrodin, Christopher Phelps, Amish Patel, Xiaopeng Bai, Ken Lind, Ninad Prabhu, Jeffrey Messer, Zhengrong Zhu, Lisa Shewchuk, Rob Reid, Alan P. Graves, Charles McHugh, Biju Mangatt
Publikováno v:
Journal of medicinal chemistry. 65(21)
E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved in many cellular processes by acting as coactivators of a large number of transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646b8bd1f0dea4957b345cc77c8b3999
https://pubmed.ncbi.nlm.nih.gov/36302181
https://pubmed.ncbi.nlm.nih.gov/36302181
Autor:
Martin Rüdiger, Chun-wa Chung, Jonathan P. Hutchinson, Christopher C. Arico-Muendel, Svetlana L. Belyanskaya, Allison Olszewski, Nerina Dodic, Duncan S. Holmes, Anthony Dossang, Andrew C. Pearce, Alistair M. Jagger, Steve Wilson, Adriana Ordóñez, David A. Lomas, Toral Jakhria, Iain Uings, Hitesh Dave, Zhengrong Zhu, Stefan J. Marciniak, Alexis Denis, Lionel Trottet, Kathrine J. Smith, Murray J. B. Brown, Imran Haq, James A. Irving, Steve Skinner, Margaret Neu, Diana Klimaszewska, Peter Eddershaw, Riccardo Ronzoni, James E. Rowedder, Andrew Brewster, John Liddle, Emilie Jigorel, Jeffrey A. Messer, Ken Lind, Rebecca Terry
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e32df3c3fc2fd491449ec31b9633ea9
https://doi.org/10.15252/emmm.202013167
https://doi.org/10.15252/emmm.202013167
Autor:
John, Liddle, Andrew C, Pearce, Christopher, Arico-Muendel, Svetlana, Belyanskaya, Andrew, Brewster, Murray, Brown, Chun-Wa, Chung, Alexis, Denis, Nerina, Dodic, Anthony, Dossang, Peter, Eddershaw, Diana, Klimaszewska, Imran, Haq, Duncan S, Holmes, Alistair, Jagger, Toral, Jakhria, Emilie, Jigorel, Ken, Lind, Jeff, Messer, Margaret, Neu, Allison, Olszewski, Riccardo, Ronzoni, James, Rowedder, Martin, Rüdiger, Steve, Skinner, Kathrine J, Smith, Lionel, Trottet, Iain, Uings, Zhengrong, Zhu, James A, Irving, David A, Lomas
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfbd08c9f4609860ae0edd678ca66212
https://pubmed.ncbi.nlm.nih.gov/33753261
https://pubmed.ncbi.nlm.nih.gov/33753261
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Autor:
Stefan J. Marciniak, Martin Rüdiger, Hitesh Dave, Jonathan P. Hutchinson, Margaret Neu, Anthony Dossang, Riccardo Ronzoni, Lionel Trottet, Adriana Ordóñez, Chun-wa Chung, Christopher C. Arico-Muendel, Alexis Denis, Allison Olszewski, Andrew C. Pearce, Ken Lind, Peter Eddershaw, Andrew Brewster, Rebecca Terry, Jeffrey A. Messer, John Liddle, Iain Uings, Emilie Jigorel, James A. Irving, Nerina Dodic, Zhengrong Zhu, Kathrine J. Smith, Duncan S. Holmes, Steve Skinner, Steve Wilson, David A. Lomas, Diana Klimaszewska, James E. Rowedder, Murray J. B. Brown, Alistair M. Jagger, Toral Jakhria, Imran Haq, Svetlana L. Belyanskaya
Severe α1-antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1-antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA-encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5dc4b6dd1fbecffcf82db1f278226c
https://doi.org/10.1101/2020.07.26.217661
https://doi.org/10.1101/2020.07.26.217661
Autor:
Meredyth Wolsky, Chaya Duraiswami, Jeff Kerns, Randy Smith, Jaydeep Bardhan, Ninad Prabhu, Ken Lind, Kate Adams, Isha Bansal, Deepak Bandyopadhyay, Joe Boyer, Dan Price, Sunny Hung, Pat Brady
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0047c27fd9f5ca3c64a63d3e3910f50b
https://doi.org/10.1021/scimeetings.0c02297
https://doi.org/10.1021/scimeetings.0c02297
Autor:
Lionel Trottet, Martin Rüdiger, Anthony Dossang, Alexis Denis, David A. Lomas, James A. Irving, Andrew C. Pearce, Andrew Brewster, John Liddle, Zhengrong Zhu, Peter Eddershaw, James E. Rowedder, Kathrine J. Smith, Chun-wa Chung, Ken Lind, Christopher C. Arico-Muendel, Jeffrey A. Messer, Allison Olszewski, Diana Klimaszewska, Murray J. B. Brown, Nerina Dodic, Duncan S. Holmes, Imran Haq, Alistair M. Jagger, Toral Jakhria, Steve Skinner, Margaret Neu, Riccardo Ronzoni, Emilie Jigorel, Iain Uings, Svetlana L. Belyanskaya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:127973
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α1-antitrypsin were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d246fffa8ad97002689f34f62901b59
https://doi.org/10.1016/j.bmcl.2021.127973
https://doi.org/10.1016/j.bmcl.2021.127973
Autor:
Ken Lind
Publikováno v:
Journal of molecular graphicsmodelling. 18(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754bf66803644b09e06c66aa53d46254
https://pubmed.ncbi.nlm.nih.gov/10994521
https://pubmed.ncbi.nlm.nih.gov/10994521