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High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System

Autor: Tomohisa Yamamoto, Toshiki Urashima, Kumiko Ayukawa, Fuminori Tokunaga, Daisuke Oikawa, Yuji Hori, Masahiro Tamaru, Tomomi Kinoshita, Kayo Umetani, Ken Katsuya

Publikováno v: SLAS Discovery. 23:1018-1029

The nuclear factor κB (NF-κB) pathway is critical for regulating immune and inflammatory responses, and uncontrolled NF-κB activation is closely associated with various inflammatory diseases and malignant tumors. The Met1-linked linear ubiquitin c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b50a2fb899c78a722ef857333734299
https://doi.org/10.1177/2472555218793066

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Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling

Autor: Toshiki Urashima, Kiyosei Iio, Fuminori Tokunaga, Yuji Hori, Daisuke Oikawa, Kumiko Ayukawa, Ken Katsuya, Shingo Obika

Publikováno v: Biochemical and biophysical research communications. 509(3)

Nuclear factor-κB (NF-κB) is a crucial transcription factor family involved in the regulation of immune and inflammatory responses and cell survival. The linear ubiquitin chain assembly complex (LUBAC), composed of the HOIL-1L, HOIP, and SHARPIN su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5c5110bee2cf9bd7322af2525bf0cc
https://pubmed.ncbi.nlm.nih.gov/30611571

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MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met

Autor: Kiyotaka Akiyama, Yutaka Saito, Motonao Nakamura, Takuya Orita, Tadashi Yamamoto, Yoshiki Yamasaki, Toshio Higuchi, Ken Katsuya, Huiping Li

Publikováno v: Molecular and cellular biology. 24(17)

Hepatocyte growth factor (HGF), a multifunctional polypeptide produced in liver, kidney, and various other tissues, elicits a broad spectrum of biological activities, including mitogenesis, morphogenesis, and survival. All of these responses are medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793da8d7bd7b16357c1efb55b9b02f49
https://pubmed.ncbi.nlm.nih.gov/15314156

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Molecular Cloning, Genomic Structure, and Expression Analysis of MUC20, a Novel Mucin Protein, Up-regulated in Injured Kidney

Autor: David A. Alcorta, Huiping Li, Takuya Orita, Yutaka Saito, William E. Munger, Ken Katsuya, Ronald J. Falk, Hong-Wei Sun, Tadashi Yamamoto, Toshio Higuchi, Hirotaka Watanabe, Yoshihisa Yamamoto, Yoshiki Yamasaki, Toyomichi Nanayama, Setsuko Nakanishi, Iwao Waga, J. Charles Jennette, Motonao Nakamura

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Here, we identify a cDNA encoding a novel mucin protein, shown previously to be up-regulated in IgAN patients, from a human kidney cDNA library. This prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43a1c85915445e5ddbc9eed43581fb0