Zobrazeno 1 - 10
of 522
pro vyhledávání: '"Ken K, Ong"'
Autor:
Nahid Yazdanpanah, Basile Jumentier, Mojgan Yazdanpanah, Ken K. Ong, John R. B. Perry, Despoina Manousaki
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Age at menarche (AAM) and age at natural menopause (ANM) are highly heritable traits and have been linked to various health outcomes. We aimed to identify circulating proteins associated with altered ANM and AAM using an unbiased two-sample
Externí odkaz:
https://doaj.org/article/4e4f13074bcf4448a01e4bb545f41948
Autor:
Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne
Publikováno v:
PLoS Biology, Vol 22, Iss 6, p e3002641 (2024)
In utero exposure to maternal obesity programs increased obesity risk. Animal models show that programmed offspring obesity is preceded by hyperphagia, but the mechanisms that mediate these changes are unknown. Using a mouse model of maternal obesity
Externí odkaz:
https://doaj.org/article/ab9fe1aaf89243808133bb36842e17d9
Autor:
Duaa Ibrahim Olwi, Felix R. Day, Tuck Seng Cheng, Laurentya Olga, Clive J. Petry, Ieuan A. Hughes, Andrea D. Smith, Ken K. Ong
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Several studies have reported associations between appetitive traits and weight gain during infancy or childhood, but none have directly compared these associations across both age periods. Here, we tested the associations between appetitive
Externí odkaz:
https://doaj.org/article/75c2300c16a94512a953236ceed9db62
Autor:
Sergio Villicaña, Juan Castillo-Fernandez, Eilis Hannon, Colette Christiansen, Pei-Chien Tsai, Jane Maddock, Diana Kuh, Matthew Suderman, Christine Power, Caroline Relton, George Ploubidis, Andrew Wong, Rebecca Hardy, Alissa Goodman, Ken K. Ong, Jordana T. Bell
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Background Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk. Results We report heritability and methylation quantitative trait locus (meQTL) analysis at 7
Externí odkaz:
https://doaj.org/article/20df056c1fab4c08a23bd6e02819b0d9
Increased basal insulin sensitivity in late pregnancy in women carrying a male fetus: a cohort study
Publikováno v:
Biology of Sex Differences, Vol 13, Iss 1, Pp 1-9 (2022)
Highlights Pregnant women carrying a male fetus were more insulin sensitive than those carrying a female at around week 28 of pregnancy in a contemporary birth cohort. They also appeared to secrete more insulin relative to their degree of insulin sen
Externí odkaz:
https://doaj.org/article/7203d446f9ed4c4c902da0c53b9c1253
Autor:
Matthias Wielscher, Pooja R. Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P. Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E. Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M. Psaty, Marie Loh, Joshua C. Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J. Deary, Marc Chadeau-Hyam, Jennifer A. Brody, Alexia Cardona, Elizabeth Selvin, Alicia K. Smith, Andrew H. Miller, Mylin A. Torres, Eirini Marouli, Xin Gào, Joyce B. J. van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J. Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L. Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A. Hurme, Olli T. Raitakari, Elena Colicino, Andrea A. Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS consortium, Karen N. Conneely, Jaspal S. Kooner, Anna Köttgen, Bastiaan T. Heijmans, Panos Deloukas, Caroline Relton, Ken K. Ong, Jordana T. Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C. Chambers, Abbas Dehghan, Marjo-Riitta Järvelin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find t
Externí odkaz:
https://doaj.org/article/715a1a2d6b1f44f19a7bcf745876ed05
Autor:
Maciej Chichlowski, Janna A. van Diepen, Andrei Prodan, Laurentya Olga, Ken K. Ong, Guus A. M. Kortman, David B. Dunger, Gabriele Gross
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
BackgroundInfant gut microbiota composition is influenced by various factors early in life. Here, we investigate associations between infant gut microbiome development, infant age, breastfeeding duration, and human milk oligosaccharides (HMO) composi
Externí odkaz:
https://doaj.org/article/c3e03e072d01455bbfe9dd437ef160e4
Autor:
Laurentya Olga, Ivana Bobeldijk-Pastorova, Richard C. Bas, Florine Seidel, Stuart G. Snowden, Samuel Furse, Ken K. Ong, Robert Kleemann, Albert Koulman
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101679- (2022)
Summary: This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early li
Externí odkaz:
https://doaj.org/article/4a2efa5f1bb348948df4b9821b6276ea
Autor:
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Mosaic loss of chromosome Y (LOY) is a common form of clonal mosaicism in leukocytes. Here, the authors extend genetic association analyses to rare variation using exome-sequence data from 82,277 males, finding that loss-of-function alleles in GIGYF1
Externí odkaz:
https://doaj.org/article/913fdc222dc74e48854e6709b1ef3e16
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background Studies of autistic children suggest that restricted eating, reduced physical activity, and sleep disorders are common; however, no studies attempt to broadly describe the diet, exercise, and sleep patterns of autistic adults or c
Externí odkaz:
https://doaj.org/article/5d90e140ce0a43f293d446d638d68713